Malignant fibrous histiocytoma of the mandible: the importance of an accurate histopathological diagnosis

Kerr, Richard; Simpson, R; Babajews, Alex

doi:10.1016/0266-4356(95)90290-2

Cited by 13 publications

(6 citation statements)

References 6 publications

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“…These tumors usually present between 1 and 70 years [11,12] with a male to female ratio of 2.5:1 [10]. These tumors develop to a size of 2-12 cm in diameter and the duration of development ranges from 3 to 12 months as reported in literature [6,7].…”

Section: Discussionmentioning

confidence: 90%

Subcutaneous Benign Fibrous Histiocytoma: Rare Presentation on Cheek—Case Report and Review of Literature

Damera

Devi

Polishetty

et al. 2015

J. Maxillofac. Oral Surg.

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Fibrous histiocytoma is a benign tumor of mesenchymal origin. The tumor frequently appears in sun exposed areas on skin and orbital tissues. The subcutaneous appearance of this tumor in deep soft tissues is rare. We present here the eighth reported case of subcutaneous benign fibrohistiocytoma in a 27 year old male patient. Histopathology of the tumor comprises fibroblastic and histiocytic cells which mimic dermatofibroma, xanthomas and nodular fasciitis. Special stains like vimentin can only differentiate these tumors.

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Section: Discussionmentioning

confidence: 90%

Subcutaneous Benign Fibrous Histiocytoma: Rare Presentation on Cheek—Case Report and Review of Literature

Damera

Devi

Polishetty

et al. 2015

J. Maxillofac. Oral Surg.

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“…Diagnosis of MFH is based on light microscopic studies, electron microscopic evaluation, and immunohistochemical assessment of molecular markers such as vimentin, a1-antitrypsin, and a1-antichymotrypsin [34,35]. The best result is achieved by using a combination of above-mentioned diagnostic methods.…”

Section: Discussionmentioning

confidence: 99%

Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer

Mesgarzadeh

Farahani

Treister

2008

Journal of Tissue Viability

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“…MFH has been regarded as the most common STS in adult life but it has been overwhelmed by controversy in terms of both histogenesis and validity as a clinicopathological entity. MFH was recognized as one of the most common STSs in adults [44]. MFH was introduced in the 1960s to describe a group of lesions presumably derived from a mixed histiocytic and fibroblastic lineage.…”

Section: Pleomorphic Sarcoma or So-called Malignant Fibrous Histiocytomamentioning

confidence: 99%

Sarcomas of the head and neck in adult patients: current concepts and future perspectives

Rapidis

2008

Expert Review of Anticancer Therapy

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Sarcomas comprise a heterogeneous and biologically diverse group of malignant neoplasms having as a common denominator their origin from mesenchymal cells. Head and neck sarcomas account for 4 to less than 20% of total body sarcomas depending on the criteria, such as age of patients (pediatric vs adult population), type of sarcomas (soft-tissue vs bony sarcomas) and site of location. Although head and neck sarcomas occur infrequently in adults, in the pediatric population one in three sarcomas will occur in the head and neck region. Most head and neck sarcomas are of the soft-tissue type, with only 20% being of bony or cartilaginous origin. Sarcomas display a diverse array of histologies and a wide spectrum of clinical behavior, ranging from relatively slow growing lesions to aggressive locally and regionally destructive tumors with the potential for systemic metastases. Osteosarcomas, rhabdomyosarcomas, pleomorphic sarcomas (malignant fibrous histiocytomas), fibrosarcomas and angiosarcomas are among the most common histologic types of sarcoma found in the head and neck. Surgery has been the primary therapeutic approach for the management of head and neck sarcomas. Survival rates for head and neck sarcomas suggest worse outcomes than for their extremity counterparts. Lymph node metastasis only occurs in 3-10% of sarcomas of the head and neck. An improvement in local disease control has recently been suggested with the combined use of surgery and radiotherapy. Conflicting results have been reported on the benefit from the use of chemotherapy as an adjuvant or neoadjuvant regimen, especially for high-grade sarcomas in long-term survival or local disease control. Encouraging results have recently been reported with the use of molecular targeted therapies with tyrosine kinase inhibitors and antiangiogenetic agents.

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Malignant fibrous histiocytoma of the mandible: the importance of an accurate histopathological diagnosis

Cited by 13 publications

References 6 publications

Subcutaneous Benign Fibrous Histiocytoma: Rare Presentation on Cheek—Case Report and Review of Literature

Subcutaneous Benign Fibrous Histiocytoma: Rare Presentation on Cheek—Case Report and Review of Literature

Malignant fibrous histiocytoma of the mandible in the context of a traumatic Marjolin's ulcer

Sarcomas of the head and neck in adult patients: current concepts and future perspectives

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