Malignant fibrous histiocytoma of the giant cell type in a cat

Garma-Aviña, Armando

doi:10.1016/0021-9975(87)90005-3

Cited by 12 publications

(16 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 In our study, the mitotic rate was considered high; however, the literature is scarce regarding PS this feature in this species PS. 2,3 Cytologic preparations of PS consist of multinucleated giant cells, neoplastic mesenchymal cells and, less commonly, a low number of smaller round cells that resemble histiocytes along with few inflammatory cells. The multinucleated giant cells may have a characteristic appearance and usually contain >30 nuclei.…”

Section: Discussionmentioning

confidence: 99%

“…In cats, two subtypes have been described: giant-cell and storiform-pleomorphic. 2,3 PS is one of the most common soft tissue sarcomas seen in people, affecting mainly the lower and upper extremities, and can be induced by radiation and metallic implants such as prostheses. 5,6 In rats, tumors can be experimentally induced by chemicals and materials (metals).…”

Section: Introductionmentioning

confidence: 99%

“…Pleomorphic sarcoma (PS), previously known as malignant fibrous histiocytoma (MFH) or anaplastic sarcoma with giant cells, is a mesenchymal neoplasm that affects humans, 1 cats, 2 dogs 3 and rats. 4 The neoplasm is composed of spindle (fibroblast/myofibroblast-like) cells often arranged in a storiform pattern interspersed with rounded cells (histiocyte-like) and multinucleated giant cells.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization

Cecco

Argenta

Bianchi

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

Objectives This study aimed to characterize the cytologic, pathologic and immunohistochemical (IHC) aspects of feline giant-cell sarcoma. Methods Biopsy and necropsy reports from the Department of Veterinary Pathology were retrieved, and 13 cases of pleomorphic sarcoma (PS) were selected according to the established epidemiologic, pathologic and IHC criteria. All samples were fixed in 10% formalin, routinely processed for histology, and stained with hematoxylin and eosin. Samples also underwent IHC testing for vimentin, ionized calcium-binding adaptor molecule 1 (Iba-1), desmin, actin and S-100. Results The mean age of the affected cats was 9.5 years, and females were over-represented. Most neoplasms were observed in the flank, lateral thorax, limbs and interscapular region, and were >2 cm in diameter. Cytology analysis revealed highly cellular preparations with three distinct populations (spindle cells, small round cells and multinucleated giant cells) in a dense eosinophilic stroma. Histologically, PS was composed of a combination of these three populations. IHC labeling for vimentin and Iba-1 was strongly positive for spindle cells and multinucleated giant cells, respectively. Desmin/actin showed variable labeling among the samples. S-100 was negative in all samples. Conclusions and relevance PS is a neoplasm of mesenchymal origin, also known as malignant fibrous histiocytoma. The predominant subtype in this study that affected the cats was the giant-cell type, characterized by the presence of multinucleated giant cells among spindle-shaped cells. These findings are similar to those described in human patients; thus, a comparison between the neoplasms seen in these species might be useful, and the knowledge of biologic behavior and overall treatment approach for humans could be extrapolated to cats.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization

Cecco

Argenta

Bianchi

et al. 2020

Journal of Feline Medicine and Surgery

View full text Add to dashboard Cite

show abstract

“…The main differential diagnosis with GCT b includes malignant giant cell tumours of soft parts and giant cell type of osteosarcoma. The former was discarded on the basis of the presence of a neoplastic lesion in the bone, the absence of anaplastic features both in multinuclear and mononuclear cells, the very low mitotic index and the presence of metastases observed in our case (Garma‐Avina, 1987). Giant cell type of osteosarcoma is characterized mainly by the formation of osteoid and bone (Slayter et al., 1994; Thompson and Pool, 2002).…”

Section: Discussionmentioning

confidence: 99%

Giant Cell Tumour of Bone in a Cat with Extraskeletal Metastases: Pathological and Immunohistochemical Study

Ferreras¹,

Fuertes²,

Pérez³

et al. 2005

Journal of Veterinary Medicine Series A

View full text Add to dashboard Cite

A case of giant cell tumour of bone (GCTb) in the lung and in a subcutaneous mass located in the right flank, with a probable primary origin in the mid-diaphysis of the right tibia, was described in a 8-year-old female cat. Numerous multinucleated giant cells were homogeneously distributed among a population of ovoid or spindle-shaped mononuclear cells. All of them were positive for vimentin suggesting a mesenchymal origin. Spindle-shaped tumour cells resemble fibroblastic cells, showing collagen fibres in their vicinity. Ovoid mononuclear cells are similar to macrophages, with a cytoplasm rich in electron-dense lysosomes. Multinucleated giant cells appear morphologically similar to osteoclasts. These findings are supported for the positive reaction to tartrate-resistant acid phosphatase (TRAP) and lysozyme, encountered only in ovoid and multinucleated giant cells. No immunoreactivity against human oestrogen receptors was observed in the nuclei of any neoplastic cells.

show abstract

“…Anaplastic sarcoma with giant cells was originally classified as malignant fibrous histiocytoma, a controversial term derived from similar lesions described in people. The tumor has been reported in a variety of domestic animal species, most frequently in dogs and cats . The exact histogenesis is still debated, although recent immunohistochemical and ultrastructural studies have suggested that the tumor originates from a pluripotent primitive dermal precursor cell consistent with fibroblasts/myofibroblasts .…”

Section: Discussionmentioning

confidence: 99%

What is your diagnosis? Ventral neck mass in a cat

Ryseff

Olver

2012

Veterinary Clinical Pathol

View full text Add to dashboard Cite

A 15-year-old female spayed domestic short-haired cat was presented for examination of a mass located in the deep dermal and subcutaneous tissues of the ventral neck close to midline. The mass had been detected one week earlier with no change in size or shape. The mass measured 2.5 9 2.5 9 3.0 cm and was nonpainful, haired, firm, and adherent to the underlying tissues. The remainder of the physical exam was unremarkable; other diagnostic testing was not performed. A fine-needle aspirate of the mass was obtained and submitted for evaluation to the clinical pathology service at Colorado State University Veterinary Diagnostic Laboratory (Figure 1). A B Figure 1. Fine-needle aspirate of a deep dermal mass located on the ventral neck of a cat. Wright-Giemsa. (A) 910 objective. (B) 950 objective.

show abstract

Malignant fibrous histiocytoma of the giant cell type in a cat

Cited by 12 publications

References 14 publications

Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization

Feline giant-cell pleomorphic sarcoma: cytologic, histologic and immunohistochemical characterization

Giant Cell Tumour of Bone in a Cat with Extraskeletal Metastases: Pathological and Immunohistochemical Study

What is your diagnosis? Ventral neck mass in a cat

Contact Info

Product

Resources

About