Malignant fibrous histiocytoma of prostate

Chin, William; Fay, Raymond; Ortega, P.

doi:10.1016/0090-4295(86)90317-1

Cited by 13 publications

(5 citation statements)

References 11 publications

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“…Other sarcomas involving the prostate that have been described as case reports include synovial sarcoma, [38][39][40] osteogenic sarcoma, 41 malignant fibrous histiocytoma, [42][43][44] angiosarcoma, 45 and malignant peripheral nerve sheath tumors. 47 A single case of granular cell tumor of the prostate has also been recorded.…”

Section: Miscellaneous Lesionsmentioning

confidence: 99%

Spindle cell lesions of the adult prostate

et al. 2007

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Prostatic spindle cell lesions are diagnostically challenging and encompass a broad array of benign and malignant processes. A subset of these lesions arises only within the prostate and generally represents entities that originate from the prostate epithelium or stroma, such as sclerosing adenosis, sarcomatoid carcinoma, stromal tumors of uncertain malignant potential (STUMP), and stromal sarcoma. Another subset of spindle cell tumors that involve the prostate are also found at other sites and include solitary fibrous tumor, leiomyosarcoma, and neural lesions among others. Finally, tumors may secondarily involve the prostate yet present as primary prostatic processes, as is evident with several cases of gastrointestinal stromal tumors (GIST). The utility of ancillary studies, including immunohistochemistry, is often limited and the main criteria for diagnosis are the morphologic findings by routine H&E stain. This review addresses the various entities that may present as spindle cell tumors within the adult prostate and discusses the functional aspects of the differential diagnosis of these lesions.

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Section: Miscellaneous Lesionsmentioning

confidence: 99%

Spindle cell lesions of the adult prostate

et al. 2007

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“…Fewer than 10 cases of MFH involving the prostate have been reported. [148][149][150] In a series of 21 adult prostate sarcomas reported by Sexton et al 57 5% were MFH, as compared with 57% LMS and 19% RMS. Patients ranged in age from 25 to 80 years (mean 58.8 years).…”

Section: Malignant Fibrous Histiocytoma ( Mfh)mentioning

confidence: 97%

“…Before the diagnosis of MFH is contemplated, the possibility of a sarcomatoid carcinoma must be excluded. Fewer than 10 cases of MFH involving the prostate have been reported 148–150 . In a series of 21 adult prostate sarcomas reported by Sexton et al.…”

Section: Miscellaneous Mesenchymal Tumours Of the Prostatementioning

confidence: 99%

Non‐epithelial neoplasms of the prostate

et al. 2011

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Non-epithelial prostatic neoplasms are infrequent and cover a broad array of entities that include both benign and highly aggressive tumours. Because they are very infrequent, there is often limited understanding of them, and the recognition of these entities, when encountered, may pose a diagnostic challenge, owing to histological overlap between them or their rarity. Most lesions in this category are mesenchymal in origin, such as prostatic stromal tumours arising from specialized prostatic stroma, smooth muscle tumours, both benign and malignant, and solitary fibrous tumours. Less commonly occurring tumours include neural, germ cell and melanocytic tumours that may be derived from cells not normally present in the prostate. Some tumours have well-established extraprostatic counterparts and, when encountered, are more commonly extraprostatic/secondary in origin; these include gastrointestinal stromal tumours and most haematopoietic tumours. The majority of tumours are characterized by a spindle cell pattern with significant overlap in morphological features. In this setting, appropriate use of immunohistochemistry and molecular studies are often necessary for accurate diagnosis, prognosis, or prediction for therapy. This review addresses and updates the clinicopathological features of the entire spectrum of non-epithelial tumours with an approach to the histological diagnosis.

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“…Metastases from MFH usually involve lungs and lymph nodes (3). No parameter, including age, history of radiation or androgen deprivation therapy, histological subtype, percentage of necrosis, percentage of sarcoma, sarcoma grade, or Gleason grade of the adenocarcinoma, was found to be predictive of outcome (2,6,9,10). Factors predictive of long-term survival were negative surgical margins and absence of metastatic disease at presentation (3,9,10).…”

Section: Discussionmentioning

confidence: 99%