1988
DOI: 10.1001/archderm.1988.01670010078025
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Malignant Fibrous Histiocytoma Arising From Discoid Lupus Erythematosus

Abstract: While the association of discoid lupus erythematosus (DLE) and subsequent squamous cell carcinoma is well known, there are no reports in the English-language literature concerning the association of DLE and soft-tissue sarcoma. We describe a patient with DLE and malignant fibrous histiocytoma.

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Cited by 13 publications
(4 citation statements)
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“…6 In our opinion, these findings, in association with the lack of a complete immunohistochemical evaluation, do not allow us to exclude an AFX, which is the most likely diagnosis because the key histologic indicators for MFH, including deep invasion (deep subcutis/fascia), necrosis, and perineural/perivascular invasion, 7 were not present. 6 The exact etiology of the development of malignancies in DLE scars is still not completely clear, but several hypotheses have been suggested. With regard to epithelial tumors, the most widespread theory emphasizes that UV light exposure plays a primary causal role, compounded by the decrease in protective melanin in DLE with hypopigmentation.…”
Section: Discussionmentioning
confidence: 86%
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“…6 In our opinion, these findings, in association with the lack of a complete immunohistochemical evaluation, do not allow us to exclude an AFX, which is the most likely diagnosis because the key histologic indicators for MFH, including deep invasion (deep subcutis/fascia), necrosis, and perineural/perivascular invasion, 7 were not present. 6 The exact etiology of the development of malignancies in DLE scars is still not completely clear, but several hypotheses have been suggested. With regard to epithelial tumors, the most widespread theory emphasizes that UV light exposure plays a primary causal role, compounded by the decrease in protective melanin in DLE with hypopigmentation.…”
Section: Discussionmentioning
confidence: 86%
“…4,5 Instead, the onset of soft tissue sarcomas in a DLE scar is a very rare event because only one case of ''malignant fibrous histiocytoma'' (MFH) has been described in the literature. 6 Regarding this last report, dating back to 1988, the authors described a dermal lesion mainly consisting of a dense infiltrate of spindle cells with moderate pleomorphism and a high mitotic rate that showed no stain for cytokeratin or epithelial membrane antigens by the immunoperoxidase method. 6 In our opinion, these findings, in association with the lack of a complete immunohistochemical evaluation, do not allow us to exclude an AFX, which is the most likely diagnosis because the key histologic indicators for MFH, including deep invasion (deep subcutis/fascia), necrosis, and perineural/perivascular invasion, 7 were not present.…”
Section: Discussionmentioning
confidence: 99%
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