Malignant extrapleural solitary fibrous tumor arising in the sublingual gland: A case report and review of literature

Iorio, Brigida; Ronchi, Andrea; Montella, Marco; Cozzolino, Immacolata; Luca, Roberto De; Rusciano, Mario; Tartaro, Gianpaolo; Colella, Giuseppe; Franco, Renato

doi:10.1016/j.oraloncology.2018.12.013

Cited by 10 publications

(5 citation statements)

References 23 publications

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“…In this study we described seven cases of oral SFT, of which all were treated with conservative local excision with a follow-up time of up to 74 months, with no recurrence reported. In the present study, SFT was diagnosed in a wide age group from young adults to elderly (24-63 years), an age variance consistent with previous publications [9,15,16].…”

Section: Discussionsupporting

confidence: 91%

“…All cases were well-circumscribed and non-infiltrative, only one case showed mild atypia, none exhibited necrosis, and mitotic activity was low in all cases, well below the threshold of 4 mitosis/10 high-power fields (HPF). Therefore, all of the cases in the present series conform with the criteria for low-risk for metastasis and recurrence [14,15].…”

Section: Resultsmentioning

confidence: 65%

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Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

et al. 2021

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Background and Objectives: This was a retrospective single-center study to analyze and describe the clinical and histological features of all cases of oral solitary fibrous tumor (SFT). Study design: the study included all consecutive cases of oral SFT diagnosed between 2008–2018 at a single tertiary center. Materials and Methods: Clinical data was retrieved from medical charts. The diagnosis of oral SFT was based upon the morphologic features of the lesions, in routine hematoxylin and eosin (H&E) stained sections and confirmed by immunohistochemical analyses including CD34, CD99, Bcl2, and stains for STAT6. Results: Seven cases of oral SFT were found. Of these, three (42%) were in males and four (58%) in females. The age range was 24–63 years (mean 47 ± 13). Four (58%) lesions were located in the buccal mucosa, two (28%) in the labial mucosa and one (14%) on the floor of the mouth. The diameter ranged between 3–50 mm (mean 22 ± 14 mm). All patients were treated with local excision. Follow-up periods were between 2–74 months (mean 41 ± 27). No recurrences were reported. Conclusions: We present a series of oral SFT, which were all non-aggressive in presentation and did not recur after conservative surgery (local excision) over a relatively long follow-up period.

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Section: Discussionsupporting

confidence: 91%

Section: Resultsmentioning

confidence: 65%

Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

et al. 2021

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“…ALDH1 is associated with tumor malignancy and self-renewal properties of stem cells in HNCs ( 182 ) and has been associated with poorer prognosis and failure of chemoradiotherapy in HNCs ( 13 , 183 ). ALDH1 acts as a stem cell marker for HNCs such as oral cancer ( 184 ), eyelid sebaceous gland carcinoma ( 185 ), benign epithelial odontogenic lesions ( 186 ), salivary gland tumor ( 187 , 188 ), lip cancer ( 189 ), sublingual adenoma ( 190 ).…”

Section: Aldh1 and Various Solid Tumorsmentioning

confidence: 99%

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Wei

Chen

et al. 2022

Front. Oncol.

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Solid tumors can be divided into benign solid tumors and solid malignant tumors in the academic community, among which malignant solid tumors are called cancers. Cancer is the second leading cause of death in the world, and the global incidence of cancer is increasing yearly New cancer patients in China are always the first. After the concept of stem cells was introduced in the tumor community, the CSC markers represented by ALDH1 have been widely studied due to their strong CSC cell characteristics and potential to be the driving force of tumor metastasis. In the research results in the past five years, it has been found that ALDH1 is highly expressed in various solid cancers such as breast cancer, lung cancer, colorectal cancer, liver cancer, gastric cancer, cervical cancer, esophageal cancer, ovarian cancer, head,and neck cancer. ALDH1 can activate and transform various pathways (such as the USP28/MYC signaling pathway, ALDH1A1/HIF-1α/VEGF axis, wnt/β-catenin signaling pathway), as well as change the intracellular pH value to promote formation and maintenance, resulting in drug resistance in tumors. By targeting and inhibiting ALDH1 in tumor stem cells, it can enhance the sensitivity of drugs and inhibit the proliferation, differentiation, and metastasis of solid tumor stem cells to some extent. This review discusses the relationship and pathway of ALDH1 with various solid tumors. It proposes that ALDH1 may serve as a diagnosis and therapeutic target for CSC, providing new insights and new strategies for reliable tumor treatment.

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“…In our experience, a 52-year-old man and a 42-year-old woman were referred to the Maxillofacial Surgery Unit for the onset of a symptomless mass involving, in the first case, the parotid gland, and in the second case, the sublingual gland [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review

et al. 2022

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(1) Background: Extrapleural solitary fibrous tumors (ESFTs) are rare oncological entities occurring in the head and neck, and even more so in the salivary glands. The clinical presentation and histologic features are usually unspecific, resulting in frequent misclassification. As an unusual tumor, ESTFs have an unpredictable clinical behavior. (2) Methods: We present two clinical cases referred to our Maxillofacial Surgery Unit for the onset of a symptomless mass involving, in one case, the parotid gland, and in the other case, the sublingual gland. (3) Results: Solitary fibrous tumors could be considered as neoplasms with intermediate biological behavior that are not entirely predictable on the basis of morphological features, as these are mostly still unknown. However, a few histologic, immunohistochemical, and imaging features, such as a hypodense signal at the T1 sequence in an MRI, or positivity for CD34, bcl2, and CD99, and the NAB2-STATS6 fusion gene, could be useful for an early differential diagnosis of ESTFs. (4) Conclusions: All patients were alive at follow-up with no evidence of disease. Surgical management should always be considered as the first choice for oncological radicality, and clinical behavior should always be defined with the help of the study of radiological and anatomopathological features.

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Malignant extrapleural solitary fibrous tumor arising in the sublingual gland: A case report and review of literature

Cited by 10 publications

References 23 publications

Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

Oral Solitary Fibrous Tumor: A Retrospective Clinico-Pathological Study and Long-Term Follow-Up

ALDH1: A potential therapeutic target for cancer stem cells in solid tumors

Solitary Extrapleural Fibrous Tumor in Salivary Glands: Our Experience—Case Series and Literature Review

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