1984
DOI: 10.1136/bjo.68.9.605
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Malignant epibulbar melanoma: natural history and treatment by radiotherapy.

Abstract: SUMMARY One hundred and eighty-four cases of malignant melanoma of the lids and epibulbar region were seen in the Radiotherapy Department of the Royal Marsden Hospital during the period 1943-74. Some of these tumours were radiosensitive and could thus be treated by radiotherapy without loss of the affected eye. Their clinical and histological features are described. The treatment policy adopted was based on radiotherapy first, and surgery reserved for the failures. A policy of observation is advised for precan… Show more

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Cited by 36 publications
(12 citation statements)
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“…3,4 Local excision with adjunctive radiotherapy or radiotherapy alone was reported by Treacher Collins in 1917 and by others but has not gained widespread acceptance. [5][6][7][8][9][10][11][12][13] Cryotherapy was popularised by Jakobiec in the 1980s and still has its advocates. [14][15][16] Treatment with a topical caustic agent was reported in 1893.…”
Section: Introductionmentioning
confidence: 99%
“…3,4 Local excision with adjunctive radiotherapy or radiotherapy alone was reported by Treacher Collins in 1917 and by others but has not gained widespread acceptance. [5][6][7][8][9][10][11][12][13] Cryotherapy was popularised by Jakobiec in the 1980s and still has its advocates. [14][15][16] Treatment with a topical caustic agent was reported in 1893.…”
Section: Introductionmentioning
confidence: 99%
“…Melanocytic tumors are the most common form of intraocular neoplasm in small animals. In cats, however, the majority of ocular melanomas arise from melanocytes in the uveal tract, rather than from limbal melanocytes 1–23 . Limbal melanomas, although rare, are usually benign in behavior and frequently warrant no more than monitoring, but have been occasionally reported to exhibit malignant tendencies especially in cats 8,10,11,13–16,19–21 …”
Section: Introductionmentioning
confidence: 99%
“…There is still disagreement about their histological classification and considerable variation in management in different centres (Silvers et af. 1978, Jacobiec 1980, Lederman, Wybar & Busby 1984. For these reasons, we have conducted a retrospective study of a series of malignant melanomas of the conjunctiva seen in Manchester and Glasgow, to provide information about the clinical course and pathological features of this disease in patients living mainly in north-west England and south-west Scotland.…”
Section: Introductionmentioning
confidence: 99%