Malignant Endovascular Papillary Angioendothelioma (Dabska Tumor)

Morgan, J.; Robinson, Morton J.; Rosen, Les; Unger, Harold M.; Niven, John

doi:10.1097/00000372-198902000-00010

Cited by 33 publications

(4 citation statements)

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“…The main differential diagnosis includes cutaneous angiosarcoma, Dabska tumour (malignant endovascular papillary angioendothelioma) [2,9], and angiomatosis. Cutaneous angiosarcoma has a very high rate of recurrence, metastasis and mortality [6].…”

Section: Discussionmentioning

confidence: 99%

Retiform haemangioendothelioma

Fukunaga

Endo

Masui

et al. 1996

Vichows Archiv A Pathol Anat

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A case of retiform haemangioendothelioma (RH), a recently described rare cutaneous low-grade angiosarcoma, is presented. A 75-year-old female had a 3.5 cm cutaneous nodule in her right lower thigh with 10 year preoperative duration. Microscopically, the dermis and subcutis contained a diffuse and infiltrative neoplasm which was characterized by long arborizing blood vessels arranged in a retiform pattern lined by cuboidal and flattened cells, occasional hobnail appearance of endothelial cells, and a prominent small lymphocytic infiltrate. Small solid areas were also found. Neither significant cellular atypia nor mitotic activity was observed. Immunohistochemically, the tumour cells reacted with endothelial markers (CD31, CD34, factor-VIII-related antigen) and bound Ulex europaeus agglutinin 1. There was no pericytic component within the tumour. The tumour was diploid by flow cytometry. The patient had a local recurrence 27 months after the excision. These findings support the view that RH is a low-grade angiosarcoma and indicate that RH must be distinguished from conventional angiosarcoma.

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Section: Discussionmentioning

confidence: 99%

Retiform haemangioendothelioma

Fukunaga

Endo

Masui

et al. 1996

Vichows Archiv A Pathol Anat

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“…Some studies have demonstrated the endothelial character of the tumor cells using immunohistochemical techniques (2–7). The tumor cells had positive immunoreactivities for CD31, CD34, CD68, and factor VIII‐related antigen, and some of them were positive for α‐SMA (2–7). In our case, there was positive immunohistochemical staining for CD31, CD34, CD68, and factor VIII‐related antigen, and α‐SMA was observed in tumor cells.…”

Section: Commentsmentioning

confidence: 99%

“…Histopathologically, EPA is characterized by endovascular proliferation of atypical endothelial cells and anastomosing vascular channels (1–9). In the histological typing of soft tissue tumour by the World Health Organization (10), EPA is defined as being composed of proliferating capillary‐sized vessels lined by cuboidal or columnar endothelial cells occasionally forming intraluminal tufts.…”

Section: Commentsmentioning

confidence: 99%

Endovascular papillary angioendothelioma (Dabska tumor) of the tongue: report of a case

Takaoka

Sakurai

Noguchi

et al. 2003

J Oral Pathology Medicine

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Endovascular papillary angioendothelioma (EPA), known as Dabska tumor, is a very rare vascular neoplasm that usually occurs in the skin or subcutis of infants and young children. There is no previous report of EPA appearing in the oral cavity. Here, we present an exceptionally rare case of EPA of the tongue in a 67-year-old man. A well-defined, reddish tumor measuring 11 mm x 8 mm x 7 mm existed at the submucosal area of the left tongue margin. Microscopic examination of an excisional biopsy specimen revealed the endothelioid tumor cells showing a papillary growth pattern, such as blood vessel-like structures. Immunohistochemical studies showed positive reactivities for CD31, CD34, alpha-smooth muscle actin, and factor VIII-related antigen in most of the tumor cells and CD68 in some tumor cells. Based on these observations, the tumor was diagnosed as an EPA.

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“…In 1969, Maria Dabska deseribed a peeuliar vaseular neoplasm, ealling it a malignant endovaseular papillary angioendothelioma (MFPA) (Dabska's tumor) (1). Sinee this original report of six eases, only five additional individual ease reports have appeared in the literature (2)(3)(4)(5)(6), and two apparently new eases were mentioned in a reeent review by Allen et al (7). The eommon and distinetive feature in all the reports seems to be the presenee of well-defined papillary tufts, filling the lumina of dilated vessels with a general eavernous lymphangioma-like appearanee.…”

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confidence: 99%

Retiform hemangioendothelioma. A new case in a child with diffuse endovascular papillary endothelial proliferation

et al. 1997

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We present a new case of retiform hemangioendothelioma (RH), an entity first described by Calonje et al. in 1994. The tumor was intradermal and located on the toe of an 11-year-old boy. Histologically, in addition to the distinctive retiform pattern of proliferating vessels in RH there are intraluminal papillae with hyaline cores similar to those seen in malignant endovascular papillary angioendothelioma (Dabska's tumor), but usually they are infrequent, focal and poorly developed. In our case, these papillary structures were well formed and distributed in a diffuse way. They were most conspicuous in superficial areas where the blood vessels were dilated. In deep areas, where the pattern of neoplastic vessels was retiform, the papillae filled their lumina totally, resembling solid cords. Our case shares the clinical and morphologic features of both retiform hemangioendothelioma and Dabska's tumor, supporting a relationship between these two kinds of neoplasms. The benign behavior of this case, with no recurrence or metastases over a 4-year follow-up, corresponds to the low malignancy of this kind of vascular neoplasm.

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Malignant Endovascular Papillary Angioendothelioma (Dabska Tumor)

Cited by 33 publications

References 0 publications

Retiform haemangioendothelioma

Retiform haemangioendothelioma

Endovascular papillary angioendothelioma (Dabska tumor) of the tongue: report of a case

Retiform hemangioendothelioma. A new case in a child with diffuse endovascular papillary endothelial proliferation

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