Malignant eccrine spiradenoma of the nasolabial fold. A case report

Challenges in diagnosis and management of a spiradenocarcinoma: a comprehensive literature review

“…Three cases presenting with distant disease underwent lymph node resection and all of these had either no evidence of disease or were alive with disease at the time of follow up. 60,61,71 However, the median follow-up duration for case reports and case series was only 16 months (range 1-228 months), therefore a number of recurrences, metastases and deaths from the disease would have not been captured. The 5-year survival rate for Avraham et al's retrospective analysis was 76.7%.…”

“…Computed tomography was the preferred modality, used in 49.1% of these cases, followed by magnetic resonance imaging (MRI) (32.7%), X-ray (30.9%), bone scan (23.6%), ultrasound (20%), positron emission tomography (PET)/computed tomography (CT) (14.5%) and finally mammography (10.9%). [4][5][6][8][9][10][11][54][55][56][57][58][60][61][62][63][67][68][69][73][74][75][77][78][79] Staiger et al have recently recommended that patients presenting with confirmed malignant spiradenoma be evaluated with an MRI and fluorodeoxyglucose (FDG)-PET/CT. 74 Details regarding a fineneedle aspirate or punch biopsy was provided for 76 case reports and case series, representing 86 (61.9%) cases.…”

“…This pre-operative test was performed 40.7% of the time, with the majority of surgeons electing to proceed firstly with excisional biopsy or wide local excision. [4][5][6][7][8][9][10][11][12][18][19][20][21][22][24][25][26][27][28][29][54][55][56][57][58][60][61][62][63][64][65][66][67][68][69][70][71][72][73][74][75][77][78][79][80][81][82][83][84][85][86][8...…”

“…Five cases underwent excision of the primary lesion with sentinel lymph node biopsy (3.7%). 1,[54][55][56][57][58][59][60][61][62] After developing one or more recurrences, four patients had amputations. 26,51,84 Avraham's retrospective analysis reported 39 (90.7%) of 43 cases that had surgical resection of spiradenocarcinoma, however, details regarding any lymph node dissection or biopsy were not provided.…”