Malignant eccrine poroma: a study of twenty-seven cases

Abstract

Twcnty-scvcn patients with malignant eccrine poroma arc presented, and their clinical and pathological features are discussed.Eccrinc ptiroma is a benign tumour of the intra-epidermal component of the eccrine sweat duct (acrosyringium). The first malignant variant reported in the literature has been attributed to Pinkus & Mehregan (1963). Since then there have been few reports of malignant eccrine poroma. We have reviewed the clinical and pathological findings in twenty-seven cases diagnosed at St Thomas's Hospital, London, between 1950 and 1981. MATERIALS AND METHODS These cases were derived from a variety of sources and thus in some instances only representative sections were available for study whilst in other cases large portions of tumour could be examined. All of the material was processed by conventional techniques and 5/1 paraffin sections were cut and stained with haematoxylin and eosin. In some instances further sections were stained by the periodic acid Schiff reaction. Where possible further clinical information was obtained from the patient's hospital notes or from the referring clinician. RESULTS Clinical findings (Table i)There were twenty-seven patients of whom twelve were female, fourteen were male and in one case the sex was unknown. The age range was from 19 to 90 years (mean 62). The duration of the lesions varied enormously (range 2 months to 40 years). In six patients the lesion had been present for 20 years or more. Although acral locations were favoured the rumours appeared at various sites. Clinically the tumours presented as verrucous plaques or polypoid growths which

Sebaceous Differentiation in Poroid Neoplasms: Report of 11 Cases, Including a Case of Metaplastic Carcinoma Associated With Apocrine Poroma (Sarcomatoid Apocrine Porocarcinoma)

“…The malignant counterpart of poroma, the porocarcinoma, has emerged as a distinct neoplasm. [33][34][35] There are few reports of metaplastic carcinomas associated with poroma, but sebaceous differentiation was not documented in those articles, [36][37][38] With few exceptions, those neoplasms have been largely described as ''carcinosarcomas.'' We and others, 38 however, posit that practically all lesions reported as such actually represent metaplastic (sarcomatoid) carcinomas, the latter defined as carcinomas which, in addition to the conventional epithelioid phenotype, exhibit a sarcomatoid spindle cell component with a mesenchymal phenotype derived from the epithelial component and which may be associated with various types of mesenchymal differentiation.…”

Eccrine Porocarcinoma: A Case Report of a Rare Skin Malignancy (Dermatopathologic View)

“…They named it epidermotropic eccrine carcinoma. Since then, in literature there have been published numerous case reports [4][5][6][7][8][9][10][11]. Due to the rarity of this oncological entity, accurate data on its incidence, etiopathogenesis, and biological behaviour are quite poor.…”

A Case of an Unusual Eccrine Poroma on the Left Forearm Area

“…Importantly, the bleeding tendency without pain or itching has not been recognized as the hall marker of malignant transformation. Shaw et al 10 reported that the lesions, which clinically presented as verrucous plaques or polypoid growths, were frequently ulcerated and occasionally bled upon trauma. Furthermore, Pinkus and Mehregan 11 reported the transformation of a long standing benign eccrine poroma that exhibited eccrine porocarcinoma.…”