Malignant diseases of hematopoietic and lymphoid tissues in Chernobyl clean-up workers

Gluzman, D F; Imamura, Nobutaka; Sklyarenko, L; Nadgornaya, V A; Zavelevich, M P; Machilo, Vasily

doi:10.1038/sj.thj.6200568

Cited by 14 publications

(13 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Too few cases of MDS were also reported in the Chernobyl accident cleanup workers [9]. Our large-sized analyses confirmed MDS risk was high in survivors exposed to higher A-bomb radiation.…”

Section: Discussionsupporting

confidence: 82%

Late hematological effects in the atomic bomb survivors

Tsukasaki

Iwanaga

Tomonaga

2007

International Congress Series

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 82%

Late hematological effects in the atomic bomb survivors

Tsukasaki

Iwanaga

Tomonaga

2007

International Congress Series

View full text Add to dashboard Cite

“…If unrepaired or misrepaired, they may lead to genome instability and carcinogenesis. IR exposure results in elevated rates of blood malignancies [4-11], breast cancer [6, 12-14], thyroid cancer [4, 6], stomach and lung cancers [6], bladder cancer [15], and renal-cell carcinomas [16]. Extensive epidemiological data show that radiation-induced cancer incidence is the highest in the exposed children [17-20].…”

Section: Introductionmentioning

confidence: 99%

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

Hudson

Kovalchuk

Koturbash

et al. 2011

Aging

View full text Add to dashboard Cite

Younger individuals are more prone to develop cancer upon ionizing radiation (IR) exposure. Radiation-induced tumors are associated with inefficient repair of IR-induced DNA damage and genome instability. Phosphorylation of histone H2AX (γ-H2AX) is the initial event in repair of IR-induced DNA damage on the chromatin flanking the DNA strand breaks. This step is crucially important for the repair of DNA strand breaks and for the maintenance of genome stability. We studied the molecular underpinnings of the age-related IR effects using an animal model. By assaying for IR-induced γ-H2AX foci we analyzed the induction and repair of the DNA strand breaks in spleen, thymus, liver, lung, kidney, cerebellum, hippocampus, frontal cortex and olfactory bulb of 7, 14, 24, 30 and 45 days old male and female mice as a function of age. We demonstrate that tissues of younger animals are much more susceptible to IR-induced DNA damage. Younger animals exhibited higher levels of γ-H2AX formation which partially correlated with cellular proliferation and expression of DNA repair proteins. Induction and persistence of γ-H2AX foci was the highest in lymphoid organs (thymus and spleen) of 7 and 14 day old mice. The lowest focal induction was seen in lung and brain of young animals. The mechanisms of cell and tissue-specificity of in vivo IR responses need to be further dissected. This study provides a roadmap for the future analyses of DNA damage and repair induction in young individuals.

show abstract

“…The full health effects of the liquidators' exposure remain the subject of much debate. It is not clear, for example, whether Chernobyl cleanup workers have experienced an increase in hematological malignancies (6) or cancers of the thyroid, brain, and other solid tumors (7). Indeed, there has been no systematic, comprehensive evaluation-nor means to carry out such an evaluation-for those working and living at or near the site.…”

Section: What Do We Know Now About the Effects Of Exposures At Chernomentioning

confidence: 98%

Genomics and Medicine at a Crossroads in Chernobyl

Cook-Deegan

Angrist

Ginsburg

2006

Science

View full text Add to dashboard Cite

Malignant diseases of hematopoietic and lymphoid tissues in Chernobyl clean-up workers

Abstract: The verified diagnosis of tumors of hematopoietic malignancies according to modern classification (EGIL, WHO) could be the prerequisite for further analytical epidemiology study of leukemias that may be related to the Chernobyl accident.

Cited by 14 publications

References 9 publications

Late hematological effects in the atomic bomb survivors

Late hematological effects in the atomic bomb survivors

Induction and persistence of radiation-induced DNA damage is more pronounced in young animals than in old animals

Genomics and Medicine at a Crossroads in Chernobyl

Contact Info

Product

Resources

About