Malignant Brenner tumor associated with a germline BRCA2 mutation

Toboni, Michael D.; Smith, Haller J.; Dilley, Sarah; Novak, Lea; Leath, Charles A.

doi:10.1016/j.gore.2017.05.006

Cited by 4 publications

(22 citation statements)

References 15 publications

(17 reference statements)

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“…The publication years ranged from 1956 to 2023. The age in 108/115 (93.9%) cases [ 2 , 8 , 9 , 10 , 11 , 12 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ] was reported. Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years.…”

Section: Resultsmentioning

confidence: 99%

“…Specifically, the mean age at presentation was 59 ± 13 years, ranging from 22 to 87 years. Presenting symptoms were reported in 113/115 (98.3%) patients [ 2 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 ]. The most common presenting symptom was abdominal pain, which was present in 42/113 patients (37.1%) [ 2 , 13 , 19 , 22 , 26 , 27 , …”

Section: Resultsmentioning

confidence: 99%

“…Two manuscripts, Miles and Norris [ 13 ] and Zhang et al [ 45 ], reported the mean value and SD; these values were used for each individual patient. There was no information regarding tumor size in 9/115 (7.8%) cases [ 19 , 32 , 33 , 40 , 41 , 51 ]. In a single case, the tumor size was mentioned as >10 cm [ 42 ].…”

Section: Resultsmentioning

confidence: 99%

“…One patient was not staged due to her poor medical status [ 35 ]. Staging was not mentioned in 14/115 (12.1%) cases [ 9 , 11 , 12 , 14 , 15 , 16 , 19 , 25 , 32 , 37 , 41 , 43 , 46 ]. The details of the staging are presented in Supplementary Table S3 .…”

Section: Resultsmentioning

confidence: 99%

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Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature

Koufopoulos,

Pouliakis,

Samaras

et al. 2024

Cancers

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Background: Malignant Brenner tumors are rare ovarian tumors, accounting for less than 1% of malignant ovarian neoplasms. The aim of this manuscript is to systematically review the current literature concerning malignant Brenner tumors. Methods: We searched three medical databases (PubMed, Scopus, and Web of Science) for relevant articles published until 15 September 2023. Results: After applying inclusion and exclusion criteria, 48 manuscripts describing 115 cases were included in this study from the English literature. Conclusions: We analyzed the demographic, clinical, pathological, and oncological characteristics of 115 patients with malignant Brenner tumors. The statistical analysis showed that recurrence was marginally statistically significantly related to tumor stage and was more common in patients with ascites and in women with abnormal CA-125 levels; patients that were treated with lymphadenectomy had better disease-specific survival.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Malignant Brenner Tumor of the Ovary: A Systematic Review of the Literature

Koufopoulos,

Pouliakis,

Samaras

et al. 2024

Cancers

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“…Both tumors were incidental, benign, and sub-centimetric in size. Literature review revealed one case of malignant BT in association with germline BRCA1 mutation and another case in association with germline BRCA2 mutation [ 42 , 43 ]. Further research is needed to investigate the role of germline BRCA 1/2 mutations in the progression of benign BTs.…”

Section: Discussionmentioning

confidence: 99%

Brenner Tumor of the Ovary: A 10-Year Single Institution Experience and Comprehensive Review of the Literature

et al. 2023

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Brenner tumors (BTs) are surface-epithelial stromal cell tumors that are categorized by the World Health Organization as benign, borderline, and malignant. Due to the rarity of BTs, the published literature on these tumors is comprised primarily of case reports and small retrospective studies. We performed a pathology database review spanning the last ten years at our institution revealing nine reported benign BTs. We collected the clinical and pathological data of patients associated with those BTs, describing the clinical presentation and imaging results, and assessing the possible risk factors associated with them. The average age at diagnosis was 58 years. BTs were discovered incidentally in 7/9 cases. The tumor was multifocal and bilateral in 1/9 cases and ranged in size from 0.2 cm to 7.5 cm. Associated Walthard rests were found in 6/9 cases and transitional metaplasia of surface ovarian and/or tubal epithelium was found in 4/9 cases. One patient had an associated mucinous cystadenoma in the ipsilateral ovary. Another patient had an associated mucinous cystadenoma in the contralateral ovary. In conclusion, we found that Walthard rests and transitional metaplasia are common findings in association with BTs. Additionally, pathologists and surgeons need to be aware of the association between mucinous cystadenomas and BTs.

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