Malignant Blue Nevus

Rubinstein, N; Kopolovic, Juri; Wexler, Menachem R.; Peled, Isaac J.

doi:10.1111/j.1524-4725.1985.tb03564.x

Cited by 24 publications

(4 citation statements)

References 10 publications

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“…Regarding pathologic findings, the reported cases (in order of frequency) included malignant melanocytic proliferations mimicking a cellular blue nevus but lacking an identifiable benign component (in 38% of cases) 5,11,[13][14][15]18,20,25,28,30,33,36,47,49 or melanomas arising in association with a distinctive blue nevus component, including (a) cellular blue nevus (26%), 4,5,11,16,18,29,40,46,50,51,53 (b) common blue nevus (21%), 5,13,22,24,27,31,32,34,37,39,41,43,52 (c) both cellular and common blue nevus (13%), 12,16,21,23,35,38,44,45,48 (d) neurocristic hamartoma (1%) 42 and (e) nevus of Ota (1%). 17 In contrast, all of the cases in our series consisted of distinctly biphenotypic melanocytic proliferations (melanoma together with a benign blue nevus component).…”

Section: Discussionmentioning

confidence: 99%

“…Not every parameter is provided for each reported case in the literature and therefore, the figures represent cases for which the specific respective parameters were reported. (a) Provides a breakdown of the associated nevus component for our cases as well as those reported in the literature (n ¼ 108) 4,5,7, (b) Age (n ¼ 111), 4,5,7,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] (c) gender (n ¼ 131) 4,5,7,[37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] and (d) anatomic distribution (n ¼ 135) 4,5,7, for all cases.…”

Section: Discussionmentioning

confidence: 99%

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Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

et al. 2014

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Melanomas arising in association with blue nevi or mimicking cellular blue nevi comprise a relatively rare and heterogeneous group of melanomas. It remains controversial which prognostic indicators predictive of outcome in conventional cutaneous melanomas are applicable to this type of melanoma. Here, we describe the clinical and histopathologic features of 24 melanomas arising in association with blue nevi and correlate these with clinical outcome. The mean patient age was 49 years (range: 23-85) with a slight female predominance (15 females:9 males). The most common anatomic locations included the head and neck region (50%), the trunk (21%), and the buttock/sacrococcygeum (17%). Histologically, the tumors were typically situated in the mid to deep dermis with variable involvement of the subcutis, but uniformly lacked a prominent intraepithelial component. The mean tumor thickness (defined as either the standard Breslow thickness or, if not available due to the lack of orientation or lack of epidermis, the largest tumor dimension) was 20.9 mm (range: 0.6-130 mm). The mean mitotic figure count was 6.5/mm 2 (range: 1-30/mm 2 ). Perineural invasion was common (38%). Followup was available for 21 cases (median 2.1 years). The median overall survival, recurrence-free survival, time to local recurrence, and time to distant recurrence were 5.2, 0.7, 2.6, and 1.6 years, respectively. Logistic regression analyses demonstrated a significant association between tumor thickness and recurrence-free survival (hazard ratio ¼ 1.02 per mm; P ¼ 0.04) and reduced time to distant metastasis (hazard ratio ¼ 1.03 per mm; P ¼ 0.02) with a similar trend toward reduced time to local recurrence (hazard ratio ¼ 1.02 per mm; P ¼ 0.07). No other parameters (age, anatomic location, mitotic figures, lymphovascular or perineural invasion, or type of associated blue nevus) emerged as significant. In addition, we provide a comprehensive review of 109 cases of melanoma blue nevus type described in the English literature and summarize our findings in this context.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

et al. 2014

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“…Malignant blue naevus (MBN) has been defined as malignant melanoma arising within a preexisting BN or melanoma arising at the site of prior biopsy or excision of a BN 69–73 . MBN is a tumour of older individuals.…”

Section: Malignant Blue Naevusmentioning

confidence: 99%

Dermal dendritic melanocytic proliferations: an update

2004

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Dermal dendritic melanocytic proliferations are a broad group of congenital and acquired melanocytic lesions characterized by the presence of dermal spindled and dendritic cells resembling melanocytes migrating from the neural crest to the epidermis. Historically, they were subdivided into dermal melanocytoses (naevus of Ota, Ito, Mongolian spot and related conditions), blue naevi and malignant blue naevi. The purpose of this review is to provide an update on recent developments in the field with emphasis on new entities and their differential diagnosis.

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“…Given the varied definitions of the term “malignant blue nevus” and the relatively small numbers of patients reported in the literature, its natural history and prognosis are poorly understood 3‐39. Nevertheless, it has been suggested that such tumors behave in a more aggressive manner than the more common conventional subtypes of melanoma 11.…”

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confidence: 99%

So‐called “malignant blue nevus”

Martin

Murali

Scolyer

et al. 2009

Cancer

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BACKGROUND: Melanomas that arise in association with or that resemble blue nevi are extremely rare and have been termed ''malignant blue nevi.'' The authors report on a single-institutional clinicopathologic study of ''blue nevus-like melanomas'' (BNLMs). METHODS: Twenty-six patients were identified with a ''malignant blue nevus'' over 29 years at the Sydney Melanoma Unit. Twenty-three patients were included in the current study after pathologic review. Clinical outcomes of those patients were compared with the outcomes in a matched control group of patients with melanoma (matched for age, sex, Breslow thickness, Clark level, ulceration, and anatomic site). RESULTS: The median patient age was 44 years, and men comprised 65% of the patients. The tumors were distributed evenly among skin sites, and their median Breslow thickness was 5.5 mm. After a median follow-up of 36.5 months, there was no difference in survival (P ¼ .702) between patients with BNLM and patients in the control group. CONCLUSIONS: BNLMs tended to present at a more advanced stage, with thicker primary tumors, but had a metastatic pattern comparable to and was not more aggressive in behavior than other types of melanoma. The authors concluded that BNLMs should be treated in the same way as any other melanoma variants based on clinical staging and pathologic prognostic indices.

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Malignant Blue Nevus

Cited by 24 publications

References 10 publications

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

Melanoma arising in association with blue nevus: a clinical and pathologic study of 24 cases and comprehensive review of the literature

Dermal dendritic melanocytic proliferations: an update

So‐called “malignant blue nevus”

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