Malignant Bileaflet Mitral Valve Prolapse Syndrome in Patients With Otherwise Idiopathic Out-of-Hospital Cardiac Arrest

Sriram, Chenni S.; Syed, Faisal F.; Ferguson, M. W. J.; Johnson, Jonathan N.; Enríquez-Sarano, Maurice; Cetta, Frank; Cannon, Bryan C.; Asirvatham, Samuel J.; Ackerman, Michael J.

doi:10.1016/j.jacc.2013.02.060

Cited by 255 publications

(346 citation statements)

References 44 publications

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“…The malignant "phenotype" is characterized by young women with bileaflet MVP, biphasic or inverted T waves in the inferior leads, and frequent complex ventricular ectopic activity with documented ventricular bigeminy or ventricular tachycardia (VT) and PVC configurations of outflow tract alternating with papillary muscle or fascicular origin (15)(16)(17).…”

Section: Causes Of Scdmentioning

confidence: 99%

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Mitral valve prolapse: an underestimated cause of sudden cardiac death—a current review of the literature

et al. 2017

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Mitral valve prolapse (MVP) is a common valve abnormality in general population. Despite the general belief of a benign disorder, several articles since the 1980s report sudden cardiac death (SCD) in MVP patients, with a substantial percentage of asymptomatic young individuals. The problem is to detect those patients at increased risk and implement methods that are suitable to prevent cardiac arrest. This review investigates the correlation between MVP and SCD, the understanding of the pathophysiology, the strategies for detecting those at risk and treatment options. A complete literature survey was performed using PubMed database search to gather available information regarding MVP and SCD. A total of 33 studies met selection criteria for inclusion in the review. MVP is an underrated cause of arrhythmic SCD. The subset of patients with malignant MVP who may be at greater risk for SCD is characterized by young women with bileaflet MVP, biphasic or inverted T waves in the inferior leads, and frequent complex ventricular ectopic activity with documented ventricular bigeminy or ventricular tachycardia (VT) and premature ventricular contractions (PVCs) configurations of outflow tract alternating with fascicular origin or papillary muscle. MVP is a common condition in the general population and is often encountered in asymptomatic individuals. The existing literature continues to generate significant controversy regarding the association of MVP with ventricular arrhythmias and SCD. Early echocardiography and cardiac magnetic resonance (CMR) are essential, as is a greater understanding of the potential electrophysiological processes of primary arrhythmogenesis and the evaluation of the genetic substrate.

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Section: Causes Of Scdmentioning

confidence: 99%

“…This type is linked to fibrosis of the basal interventricular septum in MVP cases (23). Table 1 summarizes the mechanisms of SCD in MVP patients (1,8,10,(15)(16)(17).…”

Section: Causes Of Scdmentioning

confidence: 99%

Mitral valve prolapse: an underestimated cause of sudden cardiac death—a current review of the literature

et al. 2017

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“…38 Mitral valve prolapse in female patients with ECG repolarisation abnormalities, and frequent complex ventricular ectopy, has also been associated with out-of-hospital cardiac arrest. 39,40 An association between air pollution (fine particulate matter with an aerodynamic diameter <2.5 µm and ozone) and out-of-hospital cardiac arrest has recently been demonstrated. 41 SCDs account for most cardiac and many non-AIDS-related natural deaths in HIV-infected patients.…”

Section: Department Of Defense Cardiovascular Death Registry In the Umentioning

confidence: 99%

A Clinical Perspective on Sudden Cardiac Death

2016

Arrhythmia &Amp; Electrophysiology Review

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This article presents the epidemiology, aetiology and pathophysiology of sudden cardiac death. The modern management of survivors as well as of family members of victims is discussed, as are the relevant recommendations of guidelines prepared by learned societies. KeywordsOut-of-hospital cardiac arrest, sports-related sudden death, sudden cardiac death, sudden unexplained death syndrome Disclosure: The authors have no conflicts of interest to declare.

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“…Accordingly, a malignant MVP subgroup was characterized as young women with bileaflet MVP, and frequent complex ventricular ectopy. Importantly, the complex ventricular ectopy was characterized by activity originating from both LV outflow tract and LV papillary muscles [9]. Notably, bileaflet MVP by itself without the other risk profile was shown to predict a reduced risk for SCD [10].…”

mentioning

confidence: 99%

“…A review of Myo Clinic's out of hospital cardiac arrest cases including 1200 cases, revealed 24 SCD cases which were defined as idiopathic after ruling out ischemia, various cardiomyopathy or channelopathies [9]. Ten out of these 24 idiopathic SCD cases were found to have bileaflet MVP, of whom 90% were women; 80% had biphasic or inverted T waves on ECG and 100% had a significant ventricular premature activity on a Holter monitoring.…”

mentioning

confidence: 99%

Sudden Cardiac Death in Mitral Valve Prolapse: Are we ready for Risk Stratification?

M¹,

Wolak²

2017

JCCR

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Malignant Bileaflet Mitral Valve Prolapse Syndrome in Patients With Otherwise Idiopathic Out-of-Hospital Cardiac Arrest

Cited by 255 publications

References 44 publications

Mitral valve prolapse: an underestimated cause of sudden cardiac death—a current review of the literature

Mitral valve prolapse: an underestimated cause of sudden cardiac death—a current review of the literature

A Clinical Perspective on Sudden Cardiac Death

Sudden Cardiac Death in Mitral Valve Prolapse: Are we ready for Risk Stratification?

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