Malignant apocrine sweat gland carcinoma of the caruncle

Abstract

A 34-year-old male presented with a mass in the medial aspect of the orbit. Histological examination demonstrated a malignant apocrine sweat gland carcinoma, which we consider to be most likely derived from the caruncle. We describe the clinical, radiological and histological features, with management options and a review of the relevant literature regarding sweat gland carcinomas.

Cervical lymphocele: A rare complication following salvage surgery for ocular adnexal apocrine adenocarcinoma. A case report and review of the literature

“…Ocular adnexal apocrine adenocarcinoma (OAAA) is an extremely rare tumor emerging from modified apocrine glands of the eyelids (glands of Moll), which are situated at the base of eyelash follicles. A quite unique origin of OAAA from sweat glands of the lacrimal caruncle or lacrimal sac was also described 1,3,4 . OAAA was first reported by Stout and Cooley in 1951 (ref.…”

“…OAAA was first reported by Stout and Cooley in 1951 (ref. 5 ) and only 30 cases have been reported since 1,3,4,6 . Because of its sporadic occurrence, little is known about the biological behaviour of this tumor.…”

Primary apocrine adenocarcinoma of caruncle in an elderly male

“…An exenteration was done in their case with no recurrence noted at 21 months follow-up. 5 Their behaviour varies from indolent to aggressive. Most published series found lymph node metastasis and muscle involvement in 50% of cases.…”

Poorly differentiated adenocarcinoma positive for gross cystic disease fluid protein-15 in the lacrimal drainage system: a case report and its implications for tumour origin

“…Primary poorly differentiated adenocarcinoma in the ocular region with positive immunoreactivity for gross cystic disease fluid protein-15 (GCDFP-15), a marker for apocrine epithelium, is a rare neoplasm with only a few reported cases. [1][2][3] This neoplasm is considered to arise from the accessory lacrimal glands and caruncle as well as Moll's glands. 3…”

“…[1][2][3] This neoplasm is considered to arise from the accessory lacrimal glands and caruncle as well as Moll's glands. 3…”