Malignant Adenomyoepithelioma: A Rare Entity

Robinson, Angelica S; Mayne, Jennifer; Boroumand, Nahal; Silva, H. Colleen; Eltorky, Mahmoud; Mayne, Joshua

doi:10.1111/tbj.12214

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2015

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“…Malignant features arose from either myoepithelial (25/64), epithelial (15/64), or both cell components (24/64). These MAMEs were classified as biphasic MAME or epithelial‐myoepithelail carcinoma , matrix‐producing biphasic MAME , myoepithelial carcinoma or malignant myoepithelioma arising in AME , epithelial carcinoma or adenocarcinoma, invasive ductal carcinoma or undifferentiated carcinoma arising in AME . FNA cytology was done in ten cases and only five had malignant features (5/10).…”

Section: Resultsmentioning

confidence: 99%

Malignant Adenomyoepithelioma of the Breast: A Review

et al. 2015

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n Abstract: Malignant adenomyoepithelioma (MAME) of the breast is a rare lesion characterized by dual population of epithelial and myoepithelial cells which one or both components show malignant features. We report a case of MAME of the breast in a 46-year-old woman diagnosed by fine-needle aspiration with extensive review of the literature. Classification, clinical presentation, cyto-pathologic, and immunohistochemical features are described. This lesion showed both malignant components of epithelial and myoepithelial cells in cytology and histology. The malignancy was convincingly supported by high mitotic figures, pleomorphism, and invasion in tissue sections. This review of MAMEs showed that cyto-histologic diagnosis is difficult and should be supported by immunohistochemical study. n

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Section: Resultsmentioning

confidence: 99%