Malignant acanthosis nigricans with florid papillary oral lesions

Tyler, Martin T.; Ficarra, Giuseppe; Silverman, Sol; Odom, Richard B.; Regezi, Joseph A.

doi:10.1016/s1079-2104(96)80021-7

Cited by 23 publications

(22 citation statements)

References 10 publications

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“…Darier fi rst suggested a relationship between acanthosis nigricans and internal malignancy, and Curth classifi ed acanthosis nigricans as benign, malignant, syndromic, or pseudo-acanthosis nigricans. 9,11,[13][14][15][16] Various types of acanthosis nigricans and their differing clinical features have been described previously. However, characteristic cutaneous changes such as hyperpigmentation, intense skin markings, and thickening of the skin mark the presence of acanthosis nigricans, in addition to other features.…”

Section: Discussionmentioning

confidence: 99%

Rabson-Mendenhall syndrome: two case reports and a brief review of the literature

Bathi

Parveen²,

Mutalik

et al. 2010

Odontology

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Rabson-Mendenhall syndrome is a rare, autosomal recessive disorder characterized by insulin resistance syndrome, growth retardation, coarse and senile-looking faces, mental precocity, early dentition, and pineal hyperplasia. Mutations of the insulin receptor gene affecting insulin action appear to be the basic mechanism underlying this syndrome. We report on Rabson-Mendenhall syndrome in two siblings and briefly review the literature.

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Section: Discussionmentioning

confidence: 99%

Rabson-Mendenhall syndrome: two case reports and a brief review of the literature

Bathi

Parveen²,

Mutalik

et al. 2010

Odontology

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“…Some authors use the term florid cutaneous and mucosal papillomatosis to define these clinical pictures that are frequently paraneoplastic. 2–5 …”

Section: Introductionmentioning

confidence: 99%

Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer

Bottoni

Dianzani

Pranteda

et al. 2000

Acad Dermatol Venereol

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This is the report of an 80-year-old patient with diffuse brownish hyperpigmentation and velvety thickening of the skin with onset 1 year before. Warty lesions on his limbs were present as well as papillomatous and verrucous lesions on his lips, mouth and eyelid conjunctivae with hyperkeratosis of the nipples. Biopsies, performed at different sites, showed histological pictures consistent with a diagnosis of acanthosis nigricans (AN) with florid cutaneous and mucosal papillomatosis. This type of AN is frequently associated with internal malignancy. In our patient serum levels of tissue polypeptide antigen, carcinoembryonic antigen, cytokeratin fragment and squamous cell carcinoma antigen were high and chest computed tomography scan indicated a large tumour infiltrating the right lung and extending to the mediastinum. Cytological examination of bronchial drainage revealed the presence of neoplastic cells, non-small cell type carcinoma. The most frequent cancer associated with malignant AN is gastric adenocarcinoma. Lung tumour has rarely been reported with AN. Malignant AN is sometimes associated with other cutaneous and mucosal warty lesions, as in our patient. These various skin and mucosal lesions are the expression of a systemic epithelial disorder and may help clinicians to suspect a malignant form of AN.

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“…2,3 Pharyngeal and esophageal involvement may result in debilitating symptoms for patients undergoing chemotherapy. Like most paraneoplastic dermatoses, malignant AN runs a parallel course with the underlying cancer and is expected to improve with successful treatment of that cancer.…”

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confidence: 99%

“…Another report described using methotrexate in a man with advanced gastric adenocarcinoma and florid oral AN, but he died of cancer-associated complications shortly after commencing methotrexate therapy. 3 Therapeutic success with carbon dioxide laser ablation has been reported in a patient with cervical cancer who developed persistent lip plaques despite successful oncological treatment. 5 Others report the use of retinoids for its keratolytic effects, but with varying outcomes due to the underlying cancer.…”

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confidence: 99%

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Oral Malignant Acanthosis Nigricans and Tripe Palms Associated With Renal Urothelial Carcinoma

2015

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Malignant acanthosis nigricans with florid papillary oral lesions

Cited by 23 publications

References 10 publications

Rabson-Mendenhall syndrome: two case reports and a brief review of the literature

Rabson-Mendenhall syndrome: two case reports and a brief review of the literature

Florid cutaneous and mucosal papillomatosis with acanthosis nigricans revealing a primary lung cancer

Oral Malignant Acanthosis Nigricans and Tripe Palms Associated With Renal Urothelial Carcinoma

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