Malignancy in Crohn's Disease

Kvist, Nina; Jacobsen, Ole Stig; Nørgaard, Peter; Ockelmann, Hans Henrik; Kvist, Hans Kurt; Schou, Geert; Jarnum, S.

doi:10.3109/00365528609034627

Cited by 67 publications

(20 citation statements)

References 14 publications

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“…Those who were less than 30 years old at the time of diagnosis of CD had a higher relative risk than those diagnosed at an older age. In pa tients with any colonic involvement, diagno sis at an early age entailed a comparative risk of 20.9, compared with 2.2 in those diagnosed after age 30 [8], Four earlier population-based studies found no association between CD and colo rectal cancer [20][21][22][23], However, all four failed to correct their data for the small subsets of their populations that were actually at risk, namely those with extensive, long-standing, unresected colonic disease.…”

Section: Risk In CDmentioning

confidence: 78%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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Extensive and long-standing colitis due to Crohn’s disease and ulcerative colitis is associated with an increased incidence of colorectal cancer. Colonoscopy with biopsies for mucosal dysplasia can help stratify those patients who are at increased risk. However, the effectiveness of surveillance programs has been questioned. Newer molecular techniques may eventually lead to the development of more accurate screening tools, but at this time there is not enough evidence to support their widespread use.

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Section: Risk In CDmentioning

confidence: 78%

Inflammatory Bowel Disease and Colon Cancer: A Review

Jain

Peppercorn²

1997

Dig Dis

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“…Otherwise, this may be due to differences in medical and surgical treatment. Higher colectomy rates in Denmark and Sweden may partially account for the difference observed in CRC risk [21]. Although based on a small number of cases, the overall risk of CRC is increased in Japanese patients with CD (SIR 5.80; 95% CI 2.13–12.68); this risk increase is mainly caused by rectal and anal canal/fistula cancer, not colon cancer, all CRC patients developed cancer, in these locations.…”

Section: Discussionmentioning

confidence: 99%

Malignancy in Crohn’s Disease: Incidence and Clinical Characteristics in Japan

Mizushima¹,

Ohno²,

Nakajima³

et al. 2010

Digestion

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Background/Aims: This study investigated the occurrence of malignancies in Japanese patients with Crohn’s disease (CD) and compared the incidence with that in the general population. Methods: The medical records of 294 CD patients, treated between 1989 and 2009, were reviewed and the prevalence of malignancies was assessed. Registration of person-years at risk was calculated individually, from the year of CD diagnosis until the year of cancer diagnosis, death or end of follow-up. The observed number of cancer cases was compared with the expected number, calculated on the basis of the individually computed person-years at risk and the corresponding age- and sex-specific incidence rates in the background population. Results: Thirteen cancers developed in 12 patients among a total of 4,248 person-years available for analysis. There were six CRCs, two gastric cancers, two uterine cancers, one small bowel cancer, one biliary cancer, and one cancer of unknown primary site. The risk of cancer (all sites) was significantly increased from that of the background population; SIR 2.24 (95% CI 1.19–3.83). In particular, the risk of CRC significantly increased in comparison to that of the background population; SIR 5.80 (95% CI 2.13–12.68). Conclusions: Japanese patients with CD are at increased risk of cancer, particularly CRC.

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“…Some authors support evidence of increased incidence of both large and small intestinal cancer among patients with longstanding CD [7,10]. However, the increased risk for small intestinal cancer is controversial and has not been confirmed by other studies [6,11]. It is hardly surprising that the association between CD and adenocarcinoma of the small bowel has been suggested on the basis of cumulated case reports and has not been statistically proven [6].…”

Section: Discussionmentioning

confidence: 95%