Malignancy in adult coeliac disease and idiopathic steatorrhoea

Harris, Owen; Cooke, W. T.; Thompson, Helen; Waterhouse, J. A. H.

doi:10.1016/0002-9343(67)90071-x

Cited by 420 publications

(126 citation statements)

References 36 publications

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“…As with congenital immunodeficiencies, increases in NHL are seen with autoimmune conditions such as rheumatoid arthritis (Kamel et al, 1995), systemic lupus erythematosus (Pettersson et al, 1992), Sjogren's syndrome, and celiac disease (Harris et al, 1967). Although immunosuppressive drugs used in the treatment of these conditions may cause an increase in NHL incidence, evidence suggests that the persistent inflammatory activity of the autoimmune process may have a direct link with increased risk of lymphomagenesis (Jonsson et al, 1999).…”

Section: Immunosuppressionmentioning

confidence: 99%

The epidemiology of non-Hodgkin's lymphoma

2004

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The incidence of non-Hodgkin's lymphoma (NHL) has doubled over the past two decades in the US and most other westernized countries. While improved cancer reporting, changes in lymphoma classification, and increases in AIDS-associated lymphomas have contributed to the startling escalation of disease incidence, these factors are estimated to account for only about 50% of the increase in observed incidence. The elucidation of etiologic factors and their mechanistic role in the pathogenesis of this malignancy are critical to advancements in disease prevention and treatment. Current evidence suggests that factors/conditions that precipitate either chronic antigenic stimulation or immunosuppression may provide a preferential milieu for development of NHL. High rates of lymphoma have been observed among individuals with autoimmune disease, organ transplants, and primary or acquired immunodeficiencies. Ultraviolet radiation, previously demonstrated to have an immunosuppressive effect, has also been suggested as a possible risk factor for NHL. Several pathogens have been linked to the risk of lymphoma, including Epstein-Barr virus, human immunodeficiency virus, human T-cell lymphotropic virus-1, Helicobacter pylori, hepatitis C, and simian virus 40. Whether these microbes are responsible for specific genetic mutations that initiate tumor growth, antigenic stimulation leading to B-cell proliferation, and increased potential of random cell replication errors, or immunosuppression, which thereby promotes tumor growth, has not been clearly delineated. Other exogenous factors which have been implicated in lymphomagenesis are chemicals and agricultural exposures, hair dyes, and blood transfusions. We must build on our current knowledge regarding the etiology of NHL in order that prevention, treatment, and ultimately, cure of this malignancy becomes a reality.

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Section: Immunosuppressionmentioning

confidence: 99%

The epidemiology of non-Hodgkin's lymphoma

2004

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“…This association was first described in the early 1960s 1 and subsequently confirmed [2][3][4] but as yet no consistent picture of its magnitude has emerged. Early studies indicated a relative risk for lymphoma of the order of 50-100 3,5,6 but were in general from tertiary referral centres with an interest in coeliac disease and almost certainly included patients with malignancy present at the time of diagnosis of coeliac disease. Unsurprisingly, more recent studies not affected by similar selection biases have shown lower relative risks.…”

Section: Introductionmentioning

confidence: 99%

“…Increases in the risk of gastrointestinal carcinoma in general and of carcinomas of the mouth, pharynx, oesophagus and small intestine have also been reported. 3,6,11 However, previous studies have not been able to estimate the relative risk of small intestinal lymphoma compared with the general population, as relevant population estimates of the incidence of this condition have not been readily available.…”

mentioning

confidence: 99%

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Card

West

Holmes

2004

Aliment Pharmacol Ther

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SUMMARYBackground: There is recent evidence from studies of hospitalized and of undiagnosed patients that the risk of lymphoma for people with coeliac disease may be lower than previously thought. In addition, there have been no precise estimates of small bowel lymphoma risk due to a lack of population data. Aim: To examine these and other malignant risks in a cohort of patients more typical of those seen in routine clinical practice. Methods: A prospective cohort study of incident malignancy rates in patients with coeliac disease in southern Derbyshire compared with general population figures.

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“…lesion similar to that found in celiac patients ( 18). Malignancy may develop in untreated celiac patients (12). The mechanism of this associanon is not clearl y understood bur earl y resection of a localized malignant lesion may improve surviva l (1 9).…”

mentioning

confidence: 83%

“…T cell depiction in the peripheral hlood in the untreatetl pacient with celiac disease might explain impaired blast transformation with nonspecifit m1cogens (5-7), a nd the associat1on of malignancy and ccliac disease ( 11,12).…”

mentioning

confidence: 99%

Celiac Sprue and Abdominal Lymphoma: Studies on the Cell-Mediated Immune Response of Peripheral Blood Lymphocytes

Pf¹,

Freeman²,

Thomson³

1988

Canadian Journal of Gastroenterology

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The development of primary abdominal lymphoma is a recognized complication of gluten-sensiti ve enteropachy (GSE). ln five patients with GSE plus lympho ma, the distribution and function of peripheral blood lymphocytes were determined and compared with 13 patients with GSE witho ut lymphoma and with 28 normal control subjects. The percentage ofT cells was lower in patients with GSE and GSE wirh lymphoma than in controls, whereas patients with GSE plus lymphoma had a significantly increased number of peripheral blood B lymphocytes when compared with GSE patients o r controls. There was no difference in K cell accivicy or lymphocyte responses co micogens and antige ns between controls, GSE or GSE plus lymphoma patients. Prospective studies are needed in patients with GSE co investigate whether this fall in peripheral blood T cells and rise in B lymphocytes is a marker of concurrent lymphoma. Can J Gastroenterol 1988; 2(1):12,14

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Malignancy in adult coeliac disease and idiopathic steatorrhoea

Cited by 420 publications

References 36 publications

The epidemiology of non-Hodgkin's lymphoma

The epidemiology of non-Hodgkin's lymphoma

Risk of malignancy in diagnosed coeliac disease: a 24‐year prospective, population‐based, cohort study

Celiac Sprue and Abdominal Lymphoma: Studies on the Cell-Mediated Immune Response of Peripheral Blood Lymphocytes

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