Malignancy and mesenteric panniculitis

Abstract

When MP occurs in association with malignancy, the commonest primary sites are large bowel, the lymph nodes and the urogenital tract. In those with MP on imaging, any cancer except prostate can usually be seen on the index CT. Further extensive investigation in asymptomatic patients is therefore likely to be of low yield.

Approach to the diagnosis and treatment of mesenteric panniculitis from the surgical point of view

“…The characteristic CT findings of MP are as follows: a tumoral pseudocapsule (a fatty mass separated from the base of the mesentery), an adipose ring (a normal adipose tissue surrounding the mesenteric vessels), and an intra-abdominal mass displaced adjacent bowel loops without invasion (10). As positron-emission tomography is a good alternative method to rule out malignancy for focal mesenteric masses, the most common technique used for diagnosis is CT; however, surgical approach is still the best method for definite diagnosis (11,12).…”

Cohort study of mesenteric panniculitis and its relationship to malignancy

“…The disease has been related to a variety of conditions including malignancies and inflammatory disorders. MP is associated with malignancy in 38–50 per cent of patients.…”

Mesenteric panniculitis: diagnostic precision

“…The imaging findings of MP are not specific and reflect the existence of an inflammatory process of the mesenterium that occurs both on inflammation and tumorous pathologies. [2][3][4][5][6][7] Moreover, MP has also been reported in association with systemic vasculitis such as Henoch-Schönlein purpura. 9 The imaging findings to the diagnosis of MP is based on typical CT features that include a mass effect of neighbouring gastrointestinal structures, a mesenteric slightly heterogenous well-circumscribed fatty proliferation surrounded by a peripheral capsule and internal small soft tissue nodules surrounded by a hypoattenuating halo.…”

“…[1][2][3][4] Definitive treatment for MP is still controversial in the medical literature with both medical and surgical approaches referred. For medical treatment, prednisolone, azathioprine, tamoxifen, thalidomide, antibiotics, infliximab and cyclophosphamide have been studied as acceptable options.…”

“…1 MP is an idiopathic disease but it has been associated with cancers, intra-abdominal surgery, ischaemic heart disease or autoimmune disorders on scientific literature. [1][2][3][4] The clinical presentation of the patients is diverse, but more frequently they present with abdominal pain, weight loss, fever, nausea and vomiting. The diagnosis is histopathological.…”