Malignancy and Meckel's diverticulum: A systematic literature review and 14‐year experience at a tertiary referral center

Malderen, Kathleen Van; Vijayvargiya, Priya; Camilleri, Michael; Larson, David W.; Cima, Robert R.

doi:10.1177/2050640617752771

Cited by 35 publications

(25 citation statements)

References 43 publications

(31 reference statements)

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“…El riesgo de malignidad de un DM es del 0.5%-3.2%, reportándose hasta 70 veces mayor en esta localización que en otras áreas del intestino delgado; son en su mayoría tumores neuroendocrinos (63,2%), seguidos de GIST (10,5%), adenocarcinoma (5,3%) y neoplasia epitelial pancreática (5,3%) y 15,8% metástasis secundaria (14) . Zani et al comparó la no resección versus resección de DM incidentales y demostró que el riesgo de complicaciones es menor en el grupo de no resección (1.3% versus 5.3%, respectivamente).…”

Section: Discussionunclassified

Abdomen Agudo De Etiología Inusual: Divertículo De Meckel Perforado Por Una Espina De Pescado.

Cantos¹,

Vargas²,

Vásconez³

et al. 2021

RMV

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Meckel's diverticulum is the most common congenital malformation of the digestive tract; It has a prevalence that ranges from 0.3% - 2.9% in the general population according to different publications, its incidence is higher in males with a 1.5-4: 1 ratio. In general, they present an asymptomatic course throughout life, but it is estimated that 4.2% will have some associated complication, and 3% will require hospitalization and surgery. A 37-year-old male patient who presented with nonspecific abdominal pain, the physical examination revealed a painful abdomen in the mesogastrium and right lower quadrant, without signs of peritoneal irritation. Laboratory studies without alterations; as there was no improvement in the abdominal condition, it was complemented with a computed tomographic study, which showed a hyperdense linear image in the distal ileum in relation to a probable foreign body. A surgical resolution was decided using a laparoscopic approach; as laparoscopy equipment was not available, an infraumbilical laparotomy was performed. A foreign body was identified in relation to a fishbone that crosses Meckel's diverticulum at 80 cm from the ileocecal valve. A diverticulectomy with linear stapler was performed without complications, the histopathology reported Meckel's diverticulum without evidence of ectopic tissue, and he was discharged after 48 hours. Conclusions: the presence of a Meckel diverticulum as an etiology of an acute abdomen should be taken into account and be part of the differential diagnosis of pain in the right lower quadrant; foreign body perforation being rare.

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Section: Discussionunclassified

Abdomen Agudo De Etiología Inusual: Divertículo De Meckel Perforado Por Una Espina De Pescado.

Cantos¹,

Vargas²,

Vásconez³

et al. 2021

RMV

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“…Although uncommon, tumors also occur within MD and are present in 3% to 5% of symptomatic cases. 6,8 Neuroendocrine tumors are most frequent, followed by GIST, adenocarcinoma, lymphoma, and metastasis. 8 Reports show that neuroendocrine tumors arising in MD are often associated with nodal and liver metastases regardless of tumor size and grade.…”

Section: Discussionmentioning

confidence: 99%

Pancreatic Endocrine Heterotopia Involving Meckel’s Diverticulum: A Potential Mimic of Neuroendocrine Tumor

2020

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Pancreatic heterotopia most commonly occurs in the upper gastrointestinal tract, but can occur in other sites, including Meckel’s diverticulum. When multiple histologic elements of the pancreatic tissue (acini, ducts, and endocrine cells) are present, the diagnosis is typically straightforward. In this article, we report a rare case of pure endocrine pancreatic heterotopia involving a Meckel’s diverticulum, a potential mimic of a well-differentiated neuroendocrine tumor. Several features were useful in making the distinction, including lack of desmoplasia and mass forming lesion, and immunohistochemical staining in a physiological pattern similar to that of islets of Langerhans. It is important for pathologists to be aware of this entity and its features to avoid misdiagnosis of a neuroendocrine tumor.

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Section: Figurementioning

confidence: 99%

“…Malignancy within a Meckel's diverticulum is rare, with an incidence ranging from 3.2% to 5.1% 1,4 . The most common malignancy is NETs (63.2%), followed by gastrointestinal stromal tumours (10.5%) and adenocarcinomas (5.3%) 4 . The majority of Meckel's‐associated malignancies are incidental findings during surgery for other indications: surgery for intra‐abdominal malignancy outside of the Meckel's diverticulum (73.7%), non‐malignancy‐related surgery where the Meckel's diverticulum was an incidental finding (10.5%) and surgery for a complication of the Meckel's diverticulum (5.3%) 4 …”

Section: Figurementioning

confidence: 99%

Three pathologies in one: band adhesion strangulating neuroendocrine tumour‐containing Meckel's diverticulum

Gee

Jayasekera

Pilgrim

2020

ANZ Journal of Surgery

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the anterior skull base. The high volume of testing currently being performed makes rare complications more likely to occur on a population level. Clinicians should be aware of this rare complication. This is the first reported case of a CSF leak following a nasopharyngeal swab in a patient without an existing skull base defect. Although rare, iatrogenic CSF leak is a real risk of nasopharyngeal swabs. Ensuring appropriate technique while obtaining the swab may help to minimize the possibility of this complication.

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Malignancy and Meckel's diverticulum: A systematic literature review and 14‐year experience at a tertiary referral center

Abstract: About 5% of Meckel's diverticulums resected were associated with malignant tumors, most commonly neuroendocrine tumor, and a significant portion of Meckel's diverticulum malignancy was metastatic at the time of discovery.

Cited by 35 publications

References 43 publications

Abdomen Agudo De Etiología Inusual: Divertículo De Meckel Perforado Por Una Espina De Pescado.

Abdomen Agudo De Etiología Inusual: Divertículo De Meckel Perforado Por Una Espina De Pescado.

Pancreatic Endocrine Heterotopia Involving Meckel’s Diverticulum: A Potential Mimic of Neuroendocrine Tumor

Three pathologies in one: band adhesion strangulating neuroendocrine tumour‐containing Meckel's diverticulum

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