Malignancy after renal transplantation: Analysis of incidence and risk factors in 1700 patients followed during a 25-Year period

Hiesse, C; Rieu, Philippe; Kriaa, F; Larue, J.R.; Goupy, Christophe; Neyrat, N; Charpentier, B

doi:10.1016/s0041-1345(96)00153-4

Cited by 110 publications

(62 citation statements)

References 3 publications

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“…Other risks factors are therapeutic irradiation with ultraviolet A [45, 46], immunodeficiency [48, 49, 50], chronic arsenic intoxication [51, 52], burn scars [53], and chronic ulcerative scars [54, 55, 56, 57, 58, 59, 60, 61]. …”

Section: Epidemiology Of Bccmentioning

confidence: 99%

Basal Cell Carcinomas of the Eyelids

Allali

D’Hermies

Renard³

2005

Ophthalmologica

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Basal cell carcinomas (BCC) are the more frequent malignant tumors seen in France as in other western countries. They represent 20% of eyelid tumors and 90% of eyelid malignancies. Due to their local growth, problems may arise when treating BCC, and curative exeresis must be the preferred choice each time it is possible. BCC of the eyelids have a high risk of recurrence. Recurrences are more aggressive, infiltrative and destructive and have a considerably poorer rate of cure than primary tumors. Eyelid reconstructions can entail use of complex methods which should only be carried out by a trained ophthalmologist who is also able to treat any associated age-related ocular pathologies. BCC is the most common cause leading to eyelid reconstructive surgery; a surgery which has a triple objective: tumor removal, functionality and an esthetic outcome.

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Section: Epidemiology Of Bccmentioning

confidence: 99%

Basal Cell Carcinomas of the Eyelids

Allali

D’Hermies

Renard³

2005

Ophthalmologica

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“…Patients who have lost peripheral T cells from HIV, malignancy, or recent bone marrow transplantation are susceptible to infection and some opportunistic malignancies, often with devastating results (52). Although methods exist for the in vitro expansion of pre-existing T cells, there are currently no methods that allow production of naive autologous T cells.…”

Section: Figurementioning

confidence: 99%

Human skin cells support thymus-independent T cell development

Clark

Yamanaka²,

Bai³

et al. 2005

Journal of Clinical Investigation

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Thymic tissue has previously been considered a requirement for the generation of a functional and diverse population of human T cells. We report that fibroblasts and keratinocytes from human skin arrayed on a synthetic 3-dimensional matrix support the development of functional human T cells from hematopoietic precursor cells in the absence of thymic tissue. Newly generated T cells contained T cell receptor excision circles, possessed a diverse T cell repertoire, and were functionally mature and tolerant to self MHC, indicating successful completion of positive and negative selection. Skin cell cultures expressed the AIRE, Foxn1, and Hoxa3 transcription factors and a panel of autoantigens. Skin and bone marrow biopsies can thus be used to generate de novo functional and diverse T cell populations for potential therapeutic use in immunosuppressed patients.

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“…This has been reported in renal, 1 bone marrow, 2 heart, 3 and liver [4][5][6][7][8] transplant recipients and is related to an increased number of nonmelanoma skin cancers 9 and lymphomas. 5,6 Although immunosuppression has a central role in the development of cancer, the risk for de novo tumor after orthotopic liver transplantation (OLT) has not been well studied.…”

mentioning

confidence: 98%

Risk factors for development of de novo neoplasia after liver transplantation

Xiol

Guardiola²,

Menéndez

et al. 2001

Liver Transplantation

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Liver transplant recipients are at greater risk for de novo neoplasia, especially lymphoma and nonmelanoma skin cancer; however, risk factors for this complication have not been well studied. Clinical and pathological records of 137 consecutive liver transplant recipients who had survived for at least 1 year were reviewed to register de novo neoplasia. Ten variables were analyzed for their association with the development of de novo malignancies by means of a log-rank test and stepwise selection in a multivariate analysis using the Cox proportional hazard model. Thirty de novo neoplasias appeared in 22 of 137 transplant recipients between 12 and 104 months after orthotopic liver transplantation (OLT; median follow-up, 69 months): 14 patients had 21 skin cancers, 6 patients had solid-organ cancer, and 3 patients developed a lymphoproliferative disease. Probabilities of de novo neoplasia were 13% at 5 years post-OLT and 26% at 8 years post-OLT. The only associated risk factor for any neoplasia was age. Age and hepatocarcinoma were independent risk factors associated with skin cancer. That hepatocarcinoma in the explanted liver is an independent risk factor for skin cancer suggests there is individual susceptibility to both neoplasias. (Liver Transpl 2001;7:971-975.)

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Malignancy after renal transplantation: Analysis of incidence and risk factors in 1700 patients followed during a 25-Year period

Cited by 110 publications

References 3 publications

Basal Cell Carcinomas of the Eyelids

Basal Cell Carcinomas of the Eyelids

Human skin cells support thymus-independent T cell development

Risk factors for development of de novo neoplasia after liver transplantation

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