Malignancy after Renal Transplantation: A Single-Center Experience

Abstract

Older patients had higher risk for developing malignancies, and recipients with gastrointestinal cancer had the worst survival. That suggests we need better screening programs for this type of cancer and for older patients at RTC of VUSHK.

Risk Factors for Melanoma in Renal Transplant Recipients

“…A single-center study of development of malignant neoplasm after renal transplantation identified age older than 45 years as the only risk factor associated with higher frequency of posttransplant malignant neoplasms. 38 One study found a 6% increased relative rate for each 1-year increase in age. 39 Of note, patients with living donors had significantly higher incidence of melanoma compared with those who did not.…”

“…In our USRDS cohort, patients aged 75 years and older had the highest rates of melanoma (eFigure 3 in the Supplement). A single-center study of development of malignant neoplasm after renal transplantation identified age older than 45 years as the only risk factor associated with higher frequency of posttransplant malignant neoplasms . One study found a 6% increased relative rate for each 1-year increase in age …”

Incidence of nonmelanoma skin cancer in renal transplant recipients: A systematic review and meta-analysis

“…Twenty-nine eligible studies comprising a total of 36,021 renal transplant recipients were included in the current meta-analysis [ Figure 1 ]. [ 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 ] Of the 29 publications, 25 were used for estimating the incidence of NMSC[ 14 15 16 17 18 19 20 21 22 23 25 26 27 28 29 30 33 34 35 36 37 38 39 40 41 42 ] whereas 11 publications were included to estimate the incidence of SCC and BCC. [ 14 15 18 19 22 27 32 34 38 40 42 ] Basic characteristics of included studies are presented in Table 1 .…”

“…Majority of included studies had been performed in Europe ( n = 19),[ 14 15 16 17 20 21 23 24 25 26 29 30 31 32 33 35 37 38 41 ] four in Australia and New Zealand,[ 18 19 28 34 ] three in Middle East,[ 36 40 42 ] and three in South Africa,[ 22 ] Brazil,[ 39 ] and Canada. [ 27 ] There were 16 retrospective cohort studies,[ 14 16 22 23 25 27 28 29 30 32 33 35 36 39 41 42 ] 12 prospective cohort studies. [ 17 18 19 20 21 24 26 31 34 37 38 40 ] The mean age at transplantation and follow-up period ranged from 37 to 52.2 and 1.5 to 27.75 years, respectively.…”