Malignancies in human immunodeficiency virus infected patients in India: Initial experience in the HAART era

Sharma, Surendra Kumar; Soneja, Manish; Ranjan, Shweta

doi:10.4103/0971-5916.171283

Cited by 9 publications

(13 citation statements)

References 18 publications

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“…Chitale22 has reported that NHL perhaps affects 2 per cent of HIV infected individuals in India. Another study from a tertiary care hospital in north India reported frequency of malignancies in HIV infected adult patients to be about 1 per cent (26/2598)23. They found 16 cases with NHL and three carcinoma cervix.…”

Section: Discussionmentioning

confidence: 98%

Spectrum of AIDS defining & non-AIDS defining malignancies in north India

Sachdeva¹,

Sharma²,

Singh³

et al. 2016

Indian J Med Res

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Background & objectives:There is scarcity of data on the frequency of malignancies in HIV infected individuals from India. The objective of this study was to determine the type and frequency of malignancies in HIV infected individuals attending a tertiary care hospital in north India.Methods:The study design included retrospective analysis of data of all HIV infected individuals registered in the Immunodeficiency clinic from December 2009 to December 2011 and a prospective analysis of HIV infected individuals registered from January 2012 to April 2013. The clinical details and treatment outcomes of all individuals diagnosed to have AIDS defining and non-AIDS defining malignancies were recorded.Results:Records of 2880 HIV infected individuals were reviewed. Thirty one (19 males, 12 females) individuals were diagnosed to have malignancy. AIDS defining malignancy was found in the form of non-Hodgkin's lymphoma in 12 individuals and cervical cancer in six women. Non-AIDS defining malignancies included Hodgkin's lymphoma (n=2); and chronic myelogenous leukaemia, carcinoma base of tongue, carcinoma larynx, carcinoma bronchus, sinonasal carcinoma, ovarian carcinoma, anal carcinoma, carcinoma urinary bladder, pleomorphic sarcoma, parathyroid adenoma, and renal cell carcinoma in one individual each. Mean CD4+cell count prior to ART initiation was 250 ± 195.6 (median: 187; range, 22-805) cells/μl and at the time of diagnosis of malignancy was 272 ± 202 (median: 202; range, 15-959) cells/μl. The mean CD4+ count of individuals with AIDS defining malignancy was significantly lower when compared with non-AIDS defining malignancy (P<0.001). Fourteen individuals were alive and on regular follow up, 15 had died and two cases were lost to follow up.Interpretation & conclusions:The frequency of malignancies in HIV infected patients at our centre was 1 per cent, with non-Hodgkin's lymphoma being the commonest. Further studies need to be done to document similar data from different parts of the country.

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Section: Discussionmentioning

confidence: 98%

Spectrum of AIDS defining & non-AIDS defining malignancies in north India

Sachdeva¹,

Sharma²,

Singh³

et al. 2016

Indian J Med Res

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“…6 Most common malignancy in Indian HIV patients was NHL according to previous studies. 5,6 In our study, the most common malignancies in HIV positive patients were carcinoma cervix, HNNC, carcinoma breast, carcinoma penis and anal canal and rectum cancers. Other malignancies like testicular cancer, Hodgkin's lymphoma, vaginal cancer, pancreatic cancer and acute leukaemia were not seen in our study.…”

Section: Resultsmentioning

confidence: 99%

“…The available literature on Indian patients is from small studies. 5 The incidence of malignancy in HIV patients is higher than general population, as they are more prone for maligancy. [1][2][3][4] The spectrum of malignancies in our study is different from that noted in other studies, which were also single institute studies.…”

Section: Resultsmentioning

confidence: 99%

Cancer in Human Immunodeficiency Virus Patients- A Study From a Regional Cancer Centre

Suryadevara¹,

Chinta²,

Putcha³

2017

jemds

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BACKGROUNDPatients with Human Immunodeficiency Virus (HIV) are at higher risk for cancers, either Acquired Immunodeficiency Syndrome (AIDS) defining cancers (ADCs) or non-AIDS defining cancers (NADCs). The pattern of HIV and malignancy is different among the Indian population and the literature on this topic is sparse.The aim of this study is to evaluate the pattern and spectrum of malignancies in HIV positive patients at our institute. MATERIALS AND METHODSThis is a Descriptive Study. A total of 15,964 patients were screened and of these 240 were positive for HIV (1.5%). These patients were reviewed for demographics and type of malignancy. RESULTSThe median age was 40 years for both males and females. Majority were females (61%). Most common malignancy in males was head and neck cancer (HNNC) followed by non-Hodgkin's lymphoma (NHL), carcinoma penis, rectum and anal cancers. In females, most common malignancy was carcinoma cervix followed by carcinoma breast and HNNC, NHL and thyroid cancer. Overall, most common malignancies in HIV positive were carcinoma cervix (39%), HNNC (16%), carcinoma breast (7.4%), carcinoma penis (6%) and anal canal and rectum cancer (6%).

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“…7 e literature suggests that worldwide, malignancies are encountered in about 30% patients with HIV-AIDS, but that percentage di ers sharply from that encountered in India, where it is less than 5%. 8 is may partly be explained by opportunistic infections such as tuberculosis in Indian patients, which remains the leading cause of death in the HIV-AIDS population. In our study, we retrospectively analyzed the pattern of malignancies in patients with HIV-AIDS.…”

Section: Discussionmentioning

confidence: 99%

“…Although few studies have quoted NHL as the predominant malignancy in their patients with HIV-AIDS, the predominant malignancy was cervical cancer in our patient population, as seen in few other studies. [8][9][10] Head and neck malignancies also continue to be common malignancies in men with HIV-AIDS. 10 us, an increase in malignancies induced by the human papillomavirus (HPV) can be seen in this group of patients.…”

Section: Discussionmentioning

confidence: 99%

Patterns of malignancies in patients with HIV-AIDS: a single institution observational study

Haleshappa¹

2018

JCSO

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BackgroundWith the widespread use of antiretroviral therapy in patients with HIV-AIDS, a prolonged life expectancy is now evident. This has led to an increased incidence of malignancies in this patient population. The spectrum of malignancies in these patients differs worldwide. Objective To study the patterns of AIDS-de ning malignancies (ADMs) and non-AIDS-de ning malignancies (NADMs) in patients in India with HIV-AIDS and to analyze the correlation of CD4 counts with the malignancies. Methods This retrospective study included patients presenting with a malignancy and coexisting HIV-AIDS from January 2013 through December 2016. Patients with CD4 counts at the time of diagnosis of malignancy and having received treatment were analyzed. Analyses of the patient characteristics and correlation of CD4 counts with ADM and NADM were performed. Results A total of 285 patients were evaluated. The median age was 44.8 years (range, 5-80 years). The mean CD4 count was 235.4 cells/mm 3 (range, 50-734 cells/mm 3 ; reference range, 500-1,500 cells/mm 3 ). Cervical cancer was the most common malignancy in women, and non-Hodgkin lymphoma (NHL) was the most common among men. There was a statistically signi cant difference in CD4 counts between ADMs and NADMs (P = .03). A statistical difference was also noted when the CD4 counts of patients with NHL were compared with other malignancies. However, there was no statistically signi cant difference noted when CD4 counts of patients with cervical cancer were compared with NADM (P = .914). Limitations This was a retrospective study and included only patients receiving treatment for malignancies at a single institution. Conclusions NHL and cervical cancer continue to be the most common malignancies in patients with HIV-AIDS in developing countries. NHL tends to occur in patients with lower CD4 counts. Funding/sponsorship None.

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Malignancies in human immunodeficiency virus infected patients in India: Initial experience in the HAART era

Cited by 9 publications

References 18 publications

Spectrum of AIDS defining & non-AIDS defining malignancies in north India

Spectrum of AIDS defining & non-AIDS defining malignancies in north India

Cancer in Human Immunodeficiency Virus Patients- A Study From a Regional Cancer Centre

Patterns of malignancies in patients with HIV-AIDS: a single institution observational study

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