Malignancies After Liver Transplantation: A Comparative Review

Tan-Shalaby, Jocelyn; Tempero, Margaret A.

doi:10.1055/s-2007-1007272

Cited by 44 publications

(20 citation statements)

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“…15 Whether or not the cancers commonly observed in the general population (i.e., carcinomas of the lung, breast, prostate, and colon) occur at higher incidence in the transplant population is controversial. 4,12 Our findings in liver transplant patients concur with those of Penn, 4 who reported that the incidence of these tumors is not increased after transplant. However, early reports from the Cincinnati Tumor Registry did suggest that common tumors tended to occur in transplant recipients at an earlier age than in the general population (i.e., at a mean age of 41 years).…”

Section: Discussionsupporting

confidence: 91%

Liver transplant recipients are not at increased risk for nonlymphoid solid organ tumors

Kelly¹,

Emre²,

Guy³

et al. 1998

Cancer

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Section: Discussionsupporting

confidence: 91%

Liver transplant recipients are not at increased risk for nonlymphoid solid organ tumors

Kelly¹,

Emre²,

Guy³

et al. 1998

Cancer

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“…This has been reported in renal, 1 bone marrow, 2 heart, 3 and liver [4][5][6][7][8] transplant recipients and is related to an increased number of nonmelanoma skin cancers 9 and lymphomas. 5,6 Although immunosuppression has a central role in the development of cancer, the risk for de novo tumor after orthotopic liver transplantation (OLT) has not been well studied. The aim of our study is to identify risk factors associated with de novo malignancies in liver transplant recipients.…”

mentioning

confidence: 99%

Risk factors for development of de novo neoplasia after liver transplantation

Xiol

Guardiola²,

Menéndez

et al. 2001

Liver Transplantation

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Liver transplant recipients are at greater risk for de novo neoplasia, especially lymphoma and nonmelanoma skin cancer; however, risk factors for this complication have not been well studied. Clinical and pathological records of 137 consecutive liver transplant recipients who had survived for at least 1 year were reviewed to register de novo neoplasia. Ten variables were analyzed for their association with the development of de novo malignancies by means of a log-rank test and stepwise selection in a multivariate analysis using the Cox proportional hazard model. Thirty de novo neoplasias appeared in 22 of 137 transplant recipients between 12 and 104 months after orthotopic liver transplantation (OLT; median follow-up, 69 months): 14 patients had 21 skin cancers, 6 patients had solid-organ cancer, and 3 patients developed a lymphoproliferative disease. Probabilities of de novo neoplasia were 13% at 5 years post-OLT and 26% at 8 years post-OLT. The only associated risk factor for any neoplasia was age. Age and hepatocarcinoma were independent risk factors associated with skin cancer. That hepatocarcinoma in the explanted liver is an independent risk factor for skin cancer suggests there is individual susceptibility to both neoplasias. (Liver Transpl 2001;7:971-975.)

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“…There is considerable evidence that a higher cancer rate accompanies transplantation surgery after the introduction of immunosuppressive methods [15]. Data showing increased incidence of neoplasms following therapeutic immunosuppression exist for lung carcinoma [62], lymphoma [63][64][65], bladder tumors [66] and mixed tumors [9,[67][68][69][70][71][72]. Although some patients who develop de novo malignancies have readily treatable in situ carcinomas of the cervix, low-grade skin tumors or in situ carcinomas of the vulva and perineum, these data deserve increased attention.…”

Section: Incidence Of Malignancies and Missing History Of Fevermentioning

confidence: 99%

Fever, Cancer Incidence and Spontaneous Remissions

Kleef

Jonas

Knogler³

et al. 2001

Neuroimmunomodulation

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Objective: Accumulating evidence exists for (1) an inverse correlation between the incidence of infectious diseases and cancer risk and (2) an inverse correlation between febrile infections and remissions of malignancies. This review is part of an effort of the Office of Alternative Medicine at the National Institutes of Health to examine this evidence. Methods: A review of the literature to a key word search was undertaken, using the following key words: fever, infectious diseases, neoplasm, cancer incidence and spontaneous remission. Results: The data reviewed in this article support earlier observations on the topic, i.e. that the occurrence of fever in childhood or adulthood may protect against the later onset of malignant disease and that spontaneous remissions are often preceded by feverish infections. Conclusion: Pyrogenic substances and the more recent use of whole-body hyperthermia to mimic the physiologic response to fever have successfully been administered in palliative and curative treatment protocols for metastatic cancer. Further research in this area is warranted.

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Malignancies After Liver Transplantation: A Comparative Review

Cited by 44 publications

References 0 publications

Liver transplant recipients are not at increased risk for nonlymphoid solid organ tumors

Liver transplant recipients are not at increased risk for nonlymphoid solid organ tumors

Risk factors for development of de novo neoplasia after liver transplantation

Fever, Cancer Incidence and Spontaneous Remissions

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