Malign Recurrence of Primary Chest Wall Hemangiopericytoma in the Lung after Four Years: A Case Report and Review of the Literature

Abstract

Hemangiopericytoma (HPC) may develop in every site where the endothelial tissue exits and primarily develops in the skeletal-muscular system or the skin. Adult cases of HPC generally exhibit a benign course. 20–30% of the cases may show a malign course. The tumors that show more than four mitoses, a focal area of necrosis, and increased cellularity on a magnification ×10 are considered as malign. In our paper, we presented our case who showed a lung metastasis at the end of 4 years and who developed a pathological fracture of the right humerus at the end of approximately 2 years, because hemangiopericytoma is rarely seen in the chest wall as a primary tumor.

A case study of recurrent hemagiopericytoma of the left lung

“…Regarding chemotherapy, use Panzopanib according to Lee et al (possibly due to its tyrosine, kinase inhibitory properties) [14]. Other authors use Doxorubicin in insolation or combination with Cisplatin, Etoposide, and Gemcitabin [5,20].…”

Serial transarterial embolization for the management of unresectable malignant pulmonary hemangiopericytoma: A case report and review of the literature

“…First described by Stout and Murray as Zimmerman's pericytes, these modified smooth muscle cells act to regulate luminal patency [3]. Location varies, but most tumors arise within the head and neck, muscles of the extremities and within the retroperitoneum [1,2]. Thoracic origins represent only 10% of documented cases, but have been reported to originate within the mediastinum, trachea and lungs [2].…”

“…Primary pulmonary HPC are usually diagnosed incidentally on chest radiography unless large enough to cause symptoms of chest pain, cough, dyspnea or hemoptysis [4,5]. Other reported symptoms found associated with pulmonary solitary fibrous tumor and HPC are night sweats, hypoglycemia due to the production of insulin-like growth factor and pulmonary osteoarthropathy [1,4].…”

“…Hemangiopericytomas (HPC) are rare vascular neoplasms arising from the pericytes that surround the capillary blood vessels and are rarely of thoracic origin [1,2]. Surgical excision is the standard of care as HPC have a high recurrence rate as well as 20–30% of the cases may show a malignant course [1]. Chemotherapy for unresectable and disseminated HPC can lead to complete or partial remission of the disease in 50% of the cases [1].…”

“…Surgical excision is the standard of care as HPC have a high recurrence rate as well as 20–30% of the cases may show a malignant course [1]. Chemotherapy for unresectable and disseminated HPC can lead to complete or partial remission of the disease in 50% of the cases [1]. Other therapeutic modalities are needed.…”