Malic enzyme, an “old-new player” in age at maturity in Atlantic salmon

Morán, Paloma; Ardaíz, José; Elso, Josu

doi:10.1016/j.aquaculture.2022.739013

Cited by 1 publication

(1 citation statement)

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“…Another gene was identified in the same region that encodes for a malic enzyme ( me3 ), which participates in the citric acid cycle. A locus of a malic enzyme (mMEP‐2*) located on the chromosome of vgll3 in Atlantic salmon, has been shown to affect early maturation (Morán et al., 2023). Other cases were also found, such as the oct gene participating in the urea cycle (Monzani & Moraes, 2008), and the dcaf6 gene, a component of a ligase‐ubiquitin complex.…”

Section: Discussionmentioning

confidence: 99%

Investigating the role of genetic variation in vgll3 and six6 in the domestication of gilthead seabream (Sparus aurata Linnaeus) and European seabass (Dicentrarchus labrax Linnaeus)

Moulistanos,

Nikolaou,

Sismanoglou

et al. 2023

Ecology and Evolution

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Gene function conservation is crucial in molecular ecology, especially for key traits like growth and maturation in teleost fish. The vgll3 and six6 genes are known to influence age‐at‐maturity in Atlantic salmon, but their impact on other fish species is poorly understood. Here, we investigated the association of vgll3 and six6 in the domestication of gilthead seabream and European seabass, both undergoing selective breeding for growth‐related traits in the Mediterranean. We analysed two different sets of samples using two different genotyping approaches. The first dataset comprised farmed and wild populations from Greece, genotyped for SNPs within the two genes (‘gene‐level genotyping’). The second dataset examined 300–600 k SNPs located in the chromosomes of the two genes, derived from a meta‐analysis of a Pool‐Seq experiment involving farmed and wild populations distributed widely across the Mediterranean (‘chromosome‐level genotyping’). The gene‐level analysis revealed a statistically significant allele frequency differences between farmed and wild populations on both genes in each species. This finding was partially supported by the chromosome‐level analysis, identifying highly differentiated regions may be involved in the domestication process at varying distances from the candidate genes. Noteworthy genomic features were found, such as a CpG island in gilthead seabream and novel candidate genes in European seabass, warranting further investigation. These findings support a putative role of vgll3 and six6 in the maturation and growth of gilthead seabream and European seabass, emphasizing the need for further research on their conserved function.

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Section: Discussionmentioning

confidence: 99%