Malformations Caused by Shuni Virus in Ruminants, Israel, 2014–2015

Golender, Natalia; Brenner, J.; Valdman, Motti; Khinich, Yevgeny; Bumbarov, Velizar; Panshin, Alexander; Edery, Nir; Pismanik, Shimon; Behar, Adi

doi:10.3201/eid2112.150804

Cited by 36 publications

(55 citation statements)

References 3 publications

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“…Various Simbu serogroup viruses induce abortion or severe foetal malformation in ruminants (Golender et al., ; Kirkland, ; Noda et al., ; Wernike, Elbers, & Beer, ), but some species of this group, as for example AKAV, are capable to cause encephalitis in cattle as well (Kono et al., ).…”

Section: Discussionmentioning

confidence: 99%

“…Some viruses of the Simbu serogroup, amongst them SHUV, SBV or AKAV, can cause abortions, stillbirths and severe congenital malformations (Conraths, Peters, & Beer, ; Golender et al., ; Inaba, Kurogi, & Omori, ). In addition, some members of the Simbu serogroup, for example SBV, may induce mild clinical signs like fever, decreased milk production, or diarrhoea for a few days in adult cattle (Hoffmann et al., ).…”

Section: Introductionmentioning

confidence: 99%

“…However, in 2009 SHUV was found in South African horses that suffered from neurological disease (van Eeden et al, 2012). In 2014, SHUV was also found in Israel in aborted bovine, ovine and caprine foetuses (Golender et al, 2015), further increasing its significance as an important pathogen for livestock.…”

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confidence: 99%

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Shuni virus in Israel: Neurological disease and fatalities in cattle

Golender¹,

Bumbarov²,

Assis

et al. 2019

Transbound Emerg Dis

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Summary The insect‐transmitted Shuni virus (SHUV) belongs to the Simbu serogroup of orthobunyaviruses and it is known to induce abortions, stillbirths and severe congenital malformations in ruminants and may cause neurological signs in infected horses. Here, SHUV was detected in brain samples of two Israeli cattle, which suffered from severe neurological signs that led to the deaths of the animals. During histopathological examination of the first case, a 5‐month‐old calf, small perivascular cuffs, composed mainly of neutrophils with few lymphocytes were observed in the brain stem and cerebrum. Similar infiltrates were also found to a lesser extent in the cerebellar meninges leading to the diagnosis of acute‐subacute meningoencephalitis. The histological examination of the brainstem from the second case, a 16‐month‐old heifer, revealed perivascular infiltration composed of equal numbers of macrophages and neutrophils associated with cerebral and meningeal haemorrhages. In this case encephalitis was diagnosed. Viral RNA was extracted from brain samples of both cattle that suffered from severe neurological signs and was subsequently tested by a polymerase chain reaction PCR assay specific for Simbu serogroup viruses and found positive. The presence of SHUV was subsequently confirmed by the isolation of the virus from one sample and sequence analysis of both brain samples. The comparison of the complete sequences of the coding regions of all three genome segments from both cases revealed a close relationship to Shuni viruses detected in tissue samples of aborted or malformed calves or lambs born during the last years in Israel.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Shuni virus in Israel: Neurological disease and fatalities in cattle

Golender¹,

Bumbarov²,

Assis

et al. 2019

Transbound Emerg Dis

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“…Antibodies were detected in 5/123 (3.9%) of large animal veterinarians across South Africa suggesting human exposure occur [49]. It recently emergence in Israel where it was associated with birth defects in cattle and sheep [4]. Culex theileri has been implicated as the vector (Table 1).…”

Section: Bunyavirus Genusmentioning

confidence: 99%

“…One Health surveillance for syndromes associated with arboviruses in animals; screening of mosquito vectors and surveillance for human disease may help to identify less known zoonotic arboviruses and determine their potential to emerge internationally (Figure 1). This lead to identification of Shunivirus [3,4], Middelburgvirus [5], Usutu [6] and Bagazavirus [7] in Africa and Europe raising questions on the potential of further zoonotic pathogens to emerge internationally. One Health Surveillance for arboviruses in Africa.…”

Section: Introductionmentioning

confidence: 99%

Assessing the zoonotic potential of arboviruses of African origin

Venter

2018

Current Opinion in Virology

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Several African arboviruses have emerged over the past decade in new regions where they caused major outbreaks in humans and/or animals including West Nile virus, Chikungunya virus and Zika virus. This raise questions regarding the importance of less known zoonotic arboviruses in local epidemics in Africa and their potential to emerge internationally. Syndromic surveillance in animals may serve as an early warning system to detect zoonotic arbovirus outbreaks. Rift Valley fever and Wesselsbronvirus are for example associated with abortion storms in livestock while West Nile-virus, Shuni virus and Middelburg virus causes neurological disease outbreaks in horses and other animals. Death in birds may signal Bagaza virus and Usutu virus outbreaks. This short review summarise data on less known arboviruses with zoonotic potential in Africa.

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Reproductive System

2022

Goat Medicine

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Malformations Caused by Shuni Virus in Ruminants, Israel, 2014–2015

Cited by 36 publications

References 3 publications

Shuni virus in Israel: Neurological disease and fatalities in cattle

Shuni virus in Israel: Neurological disease and fatalities in cattle

Assessing the zoonotic potential of arboviruses of African origin

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