Malformations associated with congenital absence of the gall bladder.

Turkel, Susan Beckwitt; Swanson, Virginia L.; Chandrasoma, Para

doi:10.1136/jmg.20.6.445

Cited by 56 publications

(43 citation statements)

References 21 publications

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“…3 Pathogenesis is related to embryonic development failure of the gallbladder and cystic duct to bud off from the common bile duct, during the fifth week of gestation. 6 Clinically, three presentations of the gallbladder agenesis, have been described; 1 1. . Asymptomatic (An incidental finding at laparotomy, performed for another reason) (35%), 2 2. .…”

Section: Discussionmentioning

confidence: 99%

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Agenesis of the Gallbladder Without Biliary Symptoms: Case Report

Kesici¹,

Toros²,

Bayraktar³

et al. 2014

Turkiye Klinikleri J Gastroenterohepatol

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A AB BS ST TR RA AC CT T Agenesis of the gallbladder is a rare entity, with an estimated incidence of 10-65 per 100 000. Patients are usually asymptomatic and the diagnosis is commonly made incidentally, during an abdominal surgery session or at autopsy; resulting in the patient undergoing unnecessary operative intervention. The risk of intraoperative iatrogenic injury is higher, and the associated morbidity of the procedure is greater. Here we reported the case of a gallbladder agenesis, who was being investigated for dyspeptic complaints and incidentally diagnosed as having gallbladder agenesis; her complaints owing to a gastric ulcer. As practiced here; with advanced imaging techniques of our times, the diagnosis is easily settled, so the patient can keep away from invasive modalities and their possible complications.K Ke ey y W Wo or rd ds s: : Abnormalities; gallbladder Ö ÖZ ZE ET T Safra kesesi agenezi, nadir rastlanan bir durumdur, insidansı 100 000'de 10-65 arasındadır. Hastalar genellikle semptomsuz olup; tanı bir batın içi ameliyatı sırasında veya otopsi esnasında tesadüfen konur. Dolayısıyla hasta, gereksiz bir ameliyat geçirmek zorunda kalır. Opere olunca, iyatrojenik hasar riski daha yüksek olduğu gibi, morbidite oranı da artmaktadır. Burada, dispeptik yakınmalar için tetkik edilirken tesadüfen safra kesesi agenezi tanısı alan ve şikayetlerinin mide ülserine bağlı olduğu anlaşılan bir vakayı takdim ettik. Bu vakanın da gösterdiği gibi, zamanımızın ileri görüntüleme tekniklerini kullanarak tanı kolayca konabileceğinden, hasta da invaziv işlemler ve bunlara bağlı gelişebilecek komplikasyonlardan uzak durmuş olur.A An na ah ht ta ar r K Ke el li im me el le er r: : Anormallikler; safra kesesi T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J G Ga as st tr ro oe en nt te er ro oh he ep pa at to ol l 2 20 01 14 4; ;2 21 1( (2 2)

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Section: Discussionmentioning

confidence: 99%

“…6 In many cases, associated development of common bile duct stones may be the cause. 2 Our patients' complaints were due to peptic ulcer disease and disappeared after Hp eradication therapy.…”

Section: Figurementioning

confidence: 99%

Agenesis of the Gallbladder Without Biliary Symptoms: Case Report

Kesici¹,

Toros²,

Bayraktar³

et al. 2014

Turkiye Klinikleri J Gastroenterohepatol

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“…ERCP sphincterotomy and adhesiolysis resolved the pain in these patients [11]. Agenesis of gall bladder is associated with congenital syndromes cerebrotendinous xanthomatosis, G-syndrome, Klippel-Feil syndrome, trisomy 18 and some cases reported after thalidomide therapy [12][13][14][15]. On laparoscopy if gallbladder is not visualize in GB fossa, dissection should be carried out up to the porta and usual sites for ectopic gallbladder, which are intrahepatic, retrohepatic, left sided, or within the falciform or lesser omentum, to prove the agenesis of gallbladder [8].…”

Section: Discussionmentioning

confidence: 99%

Agenesis of gallbladder: A diagnostic dilemma

Mittal¹,

Saxena²,

Kadam³

et al. 2015

IJCRI

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International Journal of Case Reports and Images (IJCRI) is an international, peer reviewed, monthly, open access, online journal, publishing high-quality, articles in all areas of basic medical sciences and clinical specialties.Aim of IJCRI is to encourage the publication of new information by providing a platform for reporting of unique, unusual and rare cases which enhance understanding of disease process, its diagnosis, management and clinico-pathologic correlations. Agenesis of gallbladder is a rare (13-65 cases/100,000) anomaly, in which about 23% patient presents with symptoms of biliary disease. In these patients, ultrasonography (USG) abdomen frequently falsely reveals shrunken or contracted gallbladder and sometimes non-visualization of gallbladder (GB) in GB fossa. Basis of these misinterpreted reports these patients undergone unnecessary surgery and may encounter iatrogenic biliary tract injuries and portal injuries because of excessive dissection to find out the absent gallbladder and ectopic gallbladder.Case Report: A 40-year-old female attended surgical outdoor with complain of pain right hypochondrium and dyspepsia since last four years patient followed-up with USG abdomen which was suggestive of chronic cholecystitis with cholelithiasis, and common bile duct (CBD) was normal in diameter on the basis of clinical symptoms and USG findings patient admitted and planned for laparoscopic cholecystectomy. On laparoscopy after removing the adhesions, exploration done up to the porta but gallbladder could not be visualized.On postoperative day-1 patient was sent for MRCP with MRI abdomen. On MRCP gallbladder and cystic duct were not visualized. CBD was normal in caliber. Liver and pancreas were normal. Hence the diagnosis of agenesis was made. Conclusion: Agenesis of gallbladder is an unusual anomaly in which about 23% presents as biliary disease. These patient frequently undergone surgery because of misinterpreted reports of USG abdomen, ERCP and CT abdomen. So, in cases with ultrasonographic diagnosis of scleroatrophic or non-visualization or suspicious of ectopic gallbladder and absence of wall echo shadow (WES) triad or double arc shadow, when non-visualization of gallbladder is present during laparoscopy or open exploration intraoperative cholangiogram, intraoperative ultrasound and postoperative MRCP or Endoscopic ultrasound (EUS) can help in the diagnosis of agenesis or ectopic gallbladder.

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“…A small ventral outgrowth develops and vacuolizes, eventually forming the GB and cystic duct. Failure of this outgrowth to form results in agenesis of the GB and the cystic duct without extrahepatic biliary atresia [7] .…”

Section: Discussionmentioning

confidence: 99%

“…Collected reviews of more than 1.5 million autopsies reported in the literature revealed only 237 cases of GB agenesis [1][2][3][4][5][6][7] , an incidence of about 1 case in every 6,334 live births. fig.…”

Section: Introductionmentioning

confidence: 99%

Agenesis of the Gallbladder with Primary Choledochal Stones

Afifi¹,

Atef²,

Wael³

2006

Med Princ Pract

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Objective: To report a case of true agenesis of the gallbladder (GB) with obstructive jaundice due to primary choledochal stone. Clinical Presentation and Intervention: A 66-year-old woman presented with a full picture of obstructive jaundice, both clinically and biochemically. Ultrasound and endoscopic retrograde cholangiopancreatography failed to show the GB but showed dilatation of extrahepatic ducts with a stone in the common bile duct (CBD). Upon exploration, the GB was found to be absent and through a choledochotomy, the stone in the CBD was removed. Conclusion: This case shows that proper exploratory laparotomy and intraoperative cholangiography may be required to confirm absence of the GB.

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Malformations associated with congenital absence of the gall bladder.

Cited by 56 publications

References 21 publications

Agenesis of the Gallbladder Without Biliary Symptoms: Case Report

Agenesis of the Gallbladder Without Biliary Symptoms: Case Report

Agenesis of gallbladder: A diagnostic dilemma

Agenesis of the Gallbladder with Primary Choledochal Stones

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