Malformaciones cardíacas en los niños con síndrome de Down

Figueroa, Jesús de Rubens; Magaña, Blanca del Pozzo; Hach, José Luis Pablos; Jiménez, Claudia Calderón; Urbina, Rocío Castrejón

doi:10.1157/13051617

Cited by 26 publications

(22 citation statements)

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“…Our results are generally in accordance with other studies [2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20] . However, our study differs from previously reported studies in two important respects.…”

Section: Discussionsupporting

confidence: 93%

“…Previous international and local studies have investigated many issues among children with Down syndrome, including: cardiovascular [6][7][8] , endocrinology [9][10][11][12] , neurology [13][14][15] , orthopaedics [16,17] , sleep [18] and visual and auditory [19][20][21][22][23] . This study aimed to examine the prevalence of various common medical issues among children with Down syndrome in Hong Kong.…”

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confidence: 99%

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Medical issues among children and teenagers with Down syndrome in Hong Kong

Yam¹,

Tse²,

Yu³

et al. 2008

Downs Syndr. Res. Pract.

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We examined the prevalence of medical problems in children and teenagers with Down syndrome in Hong Kong. Methods: Children with Down syndrome receiving care from seven regional hospitals were included and their hospital records were reviewed. A total of 407 patients, aged between 0.06 and 17.16 years were included. Cardiovascular problems were observed in 216 (53%), endocrine problems in 111 (27%), gastrointestinal problems in 46 (11%), haematological problems in 18 (4%), neurological problems in 27 (7%), sleep problems in 36 (9%), skeletal problems in 56 (14%), visual problems in 195 (48%) and auditory problems in 137 (34%). Conclusions: The prevalence of medical problems was high in children and teenagers with Down syndrome in Hong Kong and similar to previous findings elsewhere. Future studies on the local prevalence of medical problems in the adult population with Down syndrome would help to define their medical needs.ticipate. Children aged below 18 years old were included in the study. Demographic data collected included the name, sex, age, date of birth and identity card number. The age of a child was taken as the date on which the latest growth parameters were recorded. Children with the same name and identity card number were considered to be duplicate cases. For children without an identity card number submitted, they were regarded as duplicate cases if they had the same name, sex, age and date of birth. Hospital records were reviewed by participating paediatricians. Relevant data was recorded according to a pre-set questionnaire (SUPPLEMENTARY FIGURE 1). The questionnaire was designed by the participating paediatricians and epidemiologist who had special interests in Down syndrome. Nine major areas (including cardiovascular, endocrine, gastrointestinal, haematological, neurological, sleep, skeletal, visual and auditory) were studied. Each area was further classified and common conditions were listed. The paediatricians were asked to review the case records and to indicate whether the child had the condition. There was a column for "other problems" in each area so that unlisted conditions might be recorded. The paediatricians were allowed to choose the "don't Around 1 in 767 babies are born with Down syndrome in Hong Kong [1] . A number of medical conditions occur more often among children with Down syndrome than among the general population [2][3][4][5] . These children need a wide range of services delivered by medical specialists, including paediatricians, general surgeons, orthopaedic surgeons, cardiothoracic surgeons, otolaryngologists and ophthalmologists.Data on the prevalence of medical problems in these children is important for optimal service planning. Previous international and local studies have investigated many issues among children with Down syndrome, including: cardiovascular [6][7][8] , endocrinology [9][10][11][12] , neurology [13][14][15] , orthopaedics [16,17] , sleep [18] and visual and auditory [19][20][21][22][23] . This study aimed to examine the prevalence of various common m...

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Section: Discussionsupporting

confidence: 93%

mentioning

confidence: 99%

Medical issues among children and teenagers with Down syndrome in Hong Kong

Yam¹,

Tse²,

Yu³

et al. 2008

Downs Syndr. Res. Pract.

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“…7,9 Although we found no previous population-based studies of CHDs among Hispanic infants with DS, Vida et al 13 found VSD to be the most common and AVSD the least common CHD among 349 Guatemalan infants presenting for a cardiac evaluation. Similarly, de Rubens Figueroa et al 12 reported that VSD, ASD, and PDA were the most common defects in Mexican children with DS. Only 8% were diagnosed with an AVSD; however, differential survival based on cardiac status may have been a factor because participating individuals ranged up to 13 years or age.…”

Section: Discussionmentioning

confidence: 82%

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

Freeman

Bean

Allen

et al. 2008

Genetics in Medicine

257

212

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Purpose: The population-based National Down Syndrome Project combined epidemiological and molecular methods to study congenital heart defects in Down syndrome. Methods: Between 2000 and 2004, six sites collected DNA, clinical, and epidemiological information on parents and infants. We used logistic regression to examine factors associated with the most common Down syndrome-associated heart defects. Results: Of 1469 eligible infants, major cardiac defects were present in 44%; atrioventricular septal defect (39%), secundum atrial septal defect (42%), ventricular septal defect (43%), and tetralogy of Fallot (6%). Atrioventricular septal defects showed the most significant sex and ethnic differences with twice as many affected females (odds ratio, 1.93; 95% confidence interval, 1.40 -2.67) and, compared with whites, twice as many blacks (odds ratio, 2.06; 95% confidence interval, 1.32-3.21) and half as many Hispanics (odds ratio, 0.48; 95% confidence interval, 0.30 -0.77). No associations were found with origin of the nondisjunction error or with the presence of gastrointestinal defects. Conclusions: Sex and ethnic differences exist for atrioventricular septal defects in Down syndrome.Identification of genetic and environmental risk factors associated with these differences is essential to our understanding of the etiology of congenital heart defects. The National Down Syndrome Project (NDSP) seeks to investigate the etiology and phenotypic consequences of trisomy 21 Down syndrome (DS). 1 Aside from the universal findings of mental retardation and hypotonia, congenital heart defects (CHDs) are arguably the most important clinical sequelae of an extra chromosome 21. In 1998 the Atlanta Down syndrome Project (ADSP), a forerunner of the NDSP, reported that 41% of newborns with DS were born with one or more major heart defects, including atrioventricular septal defect (AVSD), secundum atrial septal defect (ASDII), ventricular septal defect (VSD), and tetralogy of Fallot (TOF). 2 Findings from the ADSP and other recent population-based studies of DS and CHDs 2-5 are summarized in Table 1.With the birth prevalence of major DS-associated CHDs well established by multiple studies using modern diagnostic methods, attention can now be directed toward understanding the etiology of these defects. Not only do infants with DS have a higher rate of CHDs than do infants without DS, but one defect, the AVSD, is particularly characteristic. To understand the etiology of CHDs in DS and of AVSD specifically, both genetic and environmental determinants must be explored. For example, several recent reports have suggested that the distribution of CHDs in DS varies by ethnicity (race/ethnicity), 6 -13 but most population-based studies have not had broad ethnic representation (Table 1). Drawing on our experience with the ADSP, we designed the multicenter NDSP to explore possible CHD risk factors singly and in combination. The NDSP is one of the largest population-based studies of CHDs in DS and the first to assemble clinical, demographic, a...

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“…Atrio-ventricular septal defect (AVSD), ventricular septal defect (VSD) and atrial septal defect (ASD) are the most common forms of CHD and recent reports have shown that the distribution of CHDs in children with DS may vary with ethnicity [3, 4, 7, 8, 14, 15, 17, 20]. …”

Section: Introductionmentioning

confidence: 99%

Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome

et al. 2010

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The aim of this study was to assess the prevalence of congenital heart defects (CHDs) and persistent pulmonary hypertension of the neonate (PPHN) in children with Down syndrome (DS) and to assess its impact on neonatal factors. It was a prospective study of a birth cohort of children with DS born between 2003 and 2006 registered by the Dutch Paediatric Surveillance Unit (DPSU). A CHD occurred in 43% of 482 children with trisomy 21. Atrioventricular septal defect was found in 54%, ventricular septal defect in 33.3% and patent ductus arteriosus in 5.8%. The incidence of PPHN in DS was 5.2%, which is significantly higher than the general population (p < 0.001). The reported mortality in newborns with DS was overall 3.3% and was still significant higher in children with a CHD versus no CHD (5.8% versus 1.5%) (p = 0.008). The presence of CHD in children with DS had no influence on their birth weight, mean gestational age and Apgar score. In neonates with DS, we found not only a 43% prevalence of CHD, but also a high incidence of PPHN at 5.2%. Early recognition of the cardiac condition of neonates with DS seems justified.

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Malformaciones cardíacas en los niños con síndrome de Down

Cited by 26 publications

References 0 publications

Medical issues among children and teenagers with Down syndrome in Hong Kong

Medical issues among children and teenagers with Down syndrome in Hong Kong

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

Prevalence of congenital heart defects and persistent pulmonary hypertension of the neonate with Down syndrome

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