Malectin gene polymorphisms promote cerebral palsy via M2‐like macrophage polarization

Shi, Weisong; Zhu, Ying; Zhou, Meiling; Ruan, Yiwen; Chen, X.

doi:10.1111/cge.13149

Cited by 4 publications

(2 citation statements)

References 25 publications

(51 reference statements)

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“…С-аллели полиморфных сайтов rs10431386 и rs7964786 ингибируют экспрессию MLEC в крови и способствуют развитию ДЦП, ингибируя поляризацию макрофагов. Эти данные указывают на вклад полиморфизмов гена MLEC в патогенез ДЦП [29].…”

Section: гены предрасположенности к дцпunclassified

Cerebral palsy biomarker

Kamilova¹,

Голота²,

Vologzhanin³

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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Cerebral palsy is a neurological disorder that is attributed to non-progressive injury or malformation that occurred in the developing fetal or infant brain. The motor disorders in cerebral palsy are often accompanied by disturbances of sensation, perception, cognition, communication, behaviour, and by epilepsy. Cerebral palsy is a complex disorder that is likely to be of multifactorial origin. Epidemiological studies have shown that the origins of most CP are prior to labor. A number of clinical risk factors for cerebral palsy have been described in the literature including preterm birth, low birth weight, inflammation, maternal infection during pregnancy and placenta pathology. Hypoxia at birth may be primary or secondary to preexisting pathology, but the currently known clinical risk factors do not explain the majority of cases. Many of these risk factors may have a genetic component. Several single nucleotide polymorphisms, DNA copy number variations and epigenetic patterns increase genetic susceptibility for cerebral palsy. Whole genome sequencing and gene expression studies may extend the percentage of cases with a genetic pathway. Clinical risk factors could act as triggers for CP where there is genetic susceptibility. These new findings should refocus research about the causes of these complex and varied neurodevelopmental disorders on the search for biomarkers of the risk of cerebral palsy. Genomics, proteomics and metabolomics have huge potential for deepening our understanding of many complex diseases by identifying diagnostic and prognostic panels of biomarkers, especially in various neurological disorders, including cerebral palsy.

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Section: гены предрасположенности к дцпunclassified

Cerebral palsy biomarker

Kamilova¹,

Голота²,

Vologzhanin³

et al. 2021

Physical and rehabilitation medicine, medical rehabilitation

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“…The malectin gene in scallops (Chlamys farreri) is involved in innate immunity [13]. Moreover, malectin stimulates M1/M2 macrophage polarization and inhibition on malectin expression by single nucleotide polymorphisms (SNPs) of MLEC gene leads to cerebral palsy [14]. The polarization of M1/M2 macrophage plays an essential role in immune system by regulating inflammatory responses [15].…”

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confidence: 99%

Molecular and functional insights into a novel teleost malectin from big-belly seahorse Hippocampus abdominalis

Sellaththurai

Shanaka

Liyanage

et al. 2020

Fish & Shellfish Immunology

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Malectin is a carbohydrate-binding lectin protein found in the endoplasmic reticulum (ER). It selectivity binds to Glc 2 -N-glycan and is involved in a glycoprotein quality control mechanism. Even though malectin may play a role in immunity, its role in innate immunity is not fully known. In the present study, we identified and characterized the malectin gene from Hippocampus abdominalis (HaMLEC). We analyzed sequence features, spatial expression levels, temporal expression profiles upon immune responses, bacterial and carbohydrate binding abilities and anti-viral properties to investigate the potential role of HaMLEC in innate immunity. The molecular weight and isoelectric point (pI) were estimated to be 31.99 kDa and 5.17, respectively. The N-terminal signal peptide, malectin superfamily domain and C-terminal transmembrane region were identified from the amino acid sequence of HaMLEC. The close evolutionary relationship of HaMLEC with other teleosts was identified by phylogenetic analysis. According to quantitative PCR (qPCR) results, HaMLEC expression was observed in all the examined tissues and high expression was observed in the ovary and brain, compared to other tested tissues. Temporal expression of HaMLEC in liver and blood tissues were significant modulated upon exposure to immunogens Edwardasiella tarda, Streptococcus iniae, polyinosinic:polycytidylic and lipopolysaccharide. The presence of carbohydrate binding modules (CBMs) of bacterial glycosyl hydrolases were functionally confirmed by a bacterial binding assay. Anti-viral activity significantly reduced viral hemorrhagic septicemia virus (VHSV) replication in cells overexpressing HaMLEC. The observed results suggested that HaMLEC may have a significant role in innate immunity in Hippocampus abdominalis.

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Single-nucleotide polymorphisms and cerebral palsy

González-Maya

González-Barrios

2021

Factors Affecting Neurodevelopment

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Malectin gene polymorphisms promote cerebral palsy via M2‐like macrophage polarization

Cited by 4 publications

References 25 publications

Cerebral palsy biomarker

Cerebral palsy biomarker

Molecular and functional insights into a novel teleost malectin from big-belly seahorse Hippocampus abdominalis

Single-nucleotide polymorphisms and cerebral palsy

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