Maleamate(–1) and Maleate(–2) Copper(II)–2,2′‐Bipyridine Complexes: Synthesis, Reactivity and Structural and Physical Studies

Abstract

(bpy)] n ·2nH 2 O (4·2nH 2 O) were isolated, depending on the crystallization method employed. Complexes 2, 3·2H 2 O and 4·2nH 2 O contain the maleate(-2) anion (LЈ 2-), which was formed in situ through metal-ion-assisted hydrolysis of the primary amide group of H 2 L. Efforts to prepare complex 3 from the direct use of maleic acid (H 2 LЈ) afforded compounds 4·2nH 2 O,

Preparation and Study of the Antibacterial Applications and Oxidative Stress Induction of Copper Maleamate-Functionalized Mesoporous Silica Nanoparticles

“…In particular, we became interested in copper(II) maleamates, because of the attractive properties that these kinds of compounds have shown in previous antibacterial studies [39,40,41,42,43]. Although these copper(II) compounds did not show a good degree of stability in physiologic medium, (even though they incorporated auxiliary bipyridine and/or phenanthroline ligands in their structure), they presented a potent antimicrobial activity which needs to be examined in detail.…”

Copper-functionalized nanostructured silica-based systems: Study of the antimicrobial applications and ROS generation against gram positive and gram negative bacteria

“…In this context, our group recently reported the preparation and study of the antibacterial properties of copper(II) maleamate complexes supported on mesoporous silica nanoparticles (MSN) [21]. Maleamates ligands were chosen because they have a rich coordination chemistry [36][37][38][39][40] and a very high potential to perturb the biological action of the enzyme maleamate amidohydrolase, negatively affecting the bacterial viability [41,42]. In addition, copper ions were used for the preparation of the metal complexes, as copper(II) compounds have a very long tradition in antibacterial studies, demonstrating a very high antimicrobial activity [43][44][45].…”