Male transmission ratio distortion supports MHC-linked cryptic female choice in the lesser kestrel (Aves: Falconidae)

Alcaide, Miguel; Rodríguez, Airam; Negro, Juan J.; Serrano, David

doi:10.1007/s00265-012-1401-9

Cited by 8 publications

(12 citation statements)

References 47 publications

(56 reference statements)

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“…In Atlantic salmons, where eggs in vitro were given the choice between sperm from MHC-identical and from completely MHC-dissimilar males, sperm from MHC-identical males was more successful in fertilization ). Similar observations of a postcopulatory fertilization advantage for MHC-similar mates were also made in Chinook salmon (Geßner et al 2017), guppies (Gasparini et al 2015), salamanders (Bos et al 2009), and kestrels (Alcaide et al 2012). Conversely, in red junglefowl, fertilization of eggs was biased toward sperm from MHC-dissimilar males (Løvlie et al 2013).…”

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confidence: 71%

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Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

et al. 2018

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Females choose specific mates in order to produce fitter offspring. However, several factors interfere with females' control over fertilization of their eggs, including sneaker males and phenotypically unpredictable allele segregation during meiosis. Mate choice at the individual level thus provides only a poor approximation for obtaining the best genetic match. Consequently, postcopulatory sperm selection by female oocytes has been proposed as a mechanism to achieve complementary combinations of parental haplotypes. Here, using controlled in vitro fertilization of three‐spined stickleback eggs, we find haplotype‐specific fertilization bias toward gametes with complementary major histocompatibility complex (MHC) immunogenes. The resulting zygote (and thus offspring) genotypes exhibit an intermediate level of individual MHC diversity that was previously shown to confer highest pathogen resistance. Our finding of haplotype‐specific gamete selection thus represents an intriguing mechanism for fine‐tuned optimization of the offspring's immune gene composition and an evolutionary advantage in the Red Queen dynamics of host‐parasite coevolution.

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confidence: 71%

“…), and kestrels (Alcaide et al. ). Conversely, in red junglefowl, fertilization of eggs was biased toward sperm from MHC‐dissimilar males (Løvlie et al.…”

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confidence: 99%

Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

et al. 2018

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“…Allele segregation patterns may also shed light about the possibility of postcopulatory selection acting upon allele number in the offspring, for instance through meiotic drive (see for instance Jeffreys and Neumann ; Alcaide et al. ). Alternatively, elucidating whether the number of MHC alleles can influence fledgling survival would be also of great interest.…”

Section: Discussionmentioning

confidence: 99%

Extraordinary MHC class II B diversity in a non‐passerine, wild bird: the Eurasian Coot Fulica atra (Aves: Rallidae)

Alcaide

Muñoz

Puente

et al. 2014

Ecology and Evolution

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The major histocompatibility complex (MHC) hosts the most polymorphic genes ever described in vertebrates. The MHC triggers the adaptive branch of the immune response, and its extraordinary variability is considered an evolutionary consequence of pathogen pressure. The last few years have witnessed the characterization of the MHC multigene family in a large diversity of bird species, unraveling important differences in its polymorphism, complexity, and evolution. Here, we characterize the first MHC class II B sequences isolated from a Rallidae species, the Eurasian Coot Fulica atra. A next-generation sequencing approach revealed up to 265 alleles that translated into 251 different amino acid sequences (β chain, exon 2) in 902 individuals. Bayesian inference identified up to 19 codons within the presumptive peptide-binding region showing pervasive evidence of positive, diversifying selection. Our analyses also detected a significant excess of high-frequency segregating sites (average Tajima's D = 2.36, P < 0.05), indicative of balancing selection. We found one to six different alleles per individual, consistent with the occurrence of at least three MHC class II B gene duplicates. However, the genotypes comprised of three alleles were by far the most abundant in the population investigated (49.4%), followed by those with two (29.6%) and four (17.5%) alleles. We suggest that these proportions are in agreement with the segregation of MHC haplotypes differing in gene copy number. The most widespread segregating haplotypes, according to our findings, would contain one single gene or two genes. The MHC class II of the Eurasian Coot is a valuable system to investigate the evolutionary implications of gene copy variation and extensive variability, the greatest ever found, to the best of our knowledge, in a wild population of a non-passerine bird.

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“…If MHC gene variability is correlated with the diversity of lymphocyte receptors, it could be anticipated that most heterozygous individuals may trigger a more efficient immune response as they are capable to bind and present a higher diversity of antigens (see Sommer, ). Natural selection plays a relevant role in shaping MHC variability in lesser kestrels (e.g., Alcaide et al, 2008, 2012), and therefore we assumed that PHA immune response could be affected by the presence of certain alleles in the genome. However, in this study PHA‐response was unrelated to MHC class II heterozygosity or to the presence of certain alleles in the genome of lesser kestrel nestlings.…”

Section: Discussionmentioning

confidence: 99%

Determinants and short‐term physiological consequences of PHA immune response in lesser kestrel nestlings

et al. 2014

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Individual immune responses are likely affected by genetic, physiological, and environmental determinants. We studied the determinants and short-term consequences of Phytohaemagglutinin (PHA) induced immune response, a commonly used immune challenge eliciting both innate and acquired immunity, on lesser kestrel (Falco naumanni) nestlings in semi-captivity conditions and with a homogeneous diet composition. We conducted a repeated measures analyses of a set of blood parameters (carotenoids, triglycerides, β-hydroxybutyrate, cholesterol, uric acid, urea, total proteins, and total antioxidant capacity), metabolic (resting metabolic rate), genotypic (MHC class II B heterozygosity), and biometric (body mass) variables. PHA challenge did not affect the studied physiological parameters on a short-term basis (<12 hr), except plasma concentrations of triglycerides and carotenoids, which decreased and increased, respectively. Uric acid was the only physiological parameter correlated with the PHA induced immune response (skin swelling), but the change of body mass, cholesterol, total antioxidant capacity, and triglycerides between sessions (i.e., post-pre treatment) were also positively correlated to PHA response. No relationships were detected between MHC gene heterozygosity or resting metabolic rate and PHA response. Our results indicate that PHA response in lesser kestrel nestlings growing in optimal conditions does not imply a severe energetic cost 12 hr after challenge, but is condition-dependent as a rapid mobilization of carotenoids and decrease of triglycerides is elicited on a short-term basis.

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Male transmission ratio distortion supports MHC-linked cryptic female choice in the lesser kestrel (Aves: Falconidae)

Cited by 8 publications

References 47 publications

Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

Cryptic haplotype-specific gamete selection yields offspring with optimal MHC immune genes

Extraordinary MHC class II B diversity in a non‐passerine, wild bird: the Eurasian Coot Fulica atra (Aves: Rallidae)

Determinants and short‐term physiological consequences of PHA immune response in lesser kestrel nestlings

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