Male systemic sclerosis and occupational silica exposure—a population‐based study

Englert, H.; Small-McMahon, J.; Davis, Kevin; O’Connor, Helen M.; Chambers, P.; Brooks, Peter

doi:10.1111/j.1445-5994.2000.tb00810.x

Cited by 46 publications

(26 citation statements)

References 5 publications

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“…Exposure assessment was based on occupational histories collected through personal interviews (Bovenzi et al 1995(Bovenzi et al , 2004Diot et al 2002) or telephone interviews (Burns et al 1996;Lacey et al 1997;Englert et al 2000;Maître et al 2004;Rosenman et al 1999) or postal questionnaire (Silman and Jones 1992). Exposure categories were established in routine registries (Brown et al 1997; Brown et al (1997), Sweden Cohort (1965-19831977-1989; nationwide registry-based cohorts of patients hospitalized for silicosis Diagnoses of silicosis as proxy for silica exposure 37 11.9-86.3 Mehlhorn et al (1999), Germany Cohort; incidence 243,900 highly exposed and 50,000 low-exposed male uranium miners Assessment of level of exposure in uranium miners 7.41 6.14-8.93 Rosenman et al (1999), USA Cohort (1987, individuals with silicosis from state registry system Mehlhorn et al 1999;Ziegler et al 1997) or using job titles (Rodnan et al 1967;Walsh 1999;Calvert et al 2003;Gold et al 2007).…”

Section: Resultsmentioning

confidence: 99%

Occupational silica exposure as a risk factor for scleroderma: a meta-analysis

McCormic

Khuder

Aryal

et al. 2010

Int Arch Occup Environ Health

115

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Section: Resultsmentioning

confidence: 99%

Occupational silica exposure as a risk factor for scleroderma: a meta-analysis

McCormic

Khuder

Aryal

et al. 2010

Int Arch Occup Environ Health

115

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“…In 1957, Erasmus [23] has reported a higher incidence of SSc in gold miners exposed to crystalline silica, compared with the general population (2/1000 vs. 0.35/1000). Previous case-control series have found a correlation between crystalline silica and SSc [23][24][25][26][27][28]. Haustein et al [29] have mentioned that SSc risk, for crystalline silica-exposed subjects, was 25 to 50 times that of unexposed subjects.…”

Section: Silicamentioning

confidence: 96%

Environmental risk factors of systemic sclerosis

Marie

Gehanno

2015

Semin Immunopathol

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Systemic sclerosis (SSc) has a complex pathogenesis. Although, there is a growing evidence that environmental factors have an impact on alterations and modulation of epigenetic determinants, resulting in SSc onset and progression. A marked correlation has thus been found between SSc onset and occupational exposure to crystalline silica and the following organic solvents: white spirit, aromatic solvents, chlorinated solvents, trichloroethylene, and ketones; the risk associated with high cumulative exposure to silica and organic solvents further appears to be strongly increased in SSc. Altogether, occupational exposure should be systematically checked in all SSc patients at diagnosis, as (1) exposed patients seem to develop more severe forms of SSc and (2) the identification of the occupational agents will allow its interruption, which may lead to potential improvement of SSc outcome. By contrast, based on current published data, there is insufficient evidence that exposure to other chemical agents (including notably pesticides as well as personal care such as silicone and hair dye), physical agents (ionizing radiation, ultraviolet radiation, electric and magnetic fields), and biological agents (infections and diet, foods, and dietary contaminants) is a causative factor of SSc. Further investigations are still warranted to identify other environmental factors that may be associated with SSc onset and progression.

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“…69 70 A recent study of 160 Australian males living, deceased, or of unknown vital status with systemic sclerosis found a significant difference in the number of cases with occupational crystalline silica exposure compared with controls (OR = 3.93; 95% CI 1.84 to 8.54; 60/160 cases and 11/83 controls with potential crystalline silica exposure). 71 After adjustment for socioeconomic status, the OR decreased to 2.51 (95% CI 1.28 to 4.98). In contrast, odds ratios were not increased among crystalline silica exposed women from Ohio.…”

Section: Systemic Sclerosismentioning

confidence: 97%

Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States

2003

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Background:Although crystalline silica exposure is associated with silicosis, lung cancer, pulmonary tuberculosis, and chronic obstructive pulmonary disease (COPD), there is less support for an association with autoimmune disease, and renal disease.Methods:Using data from the US National Occupational Mortality Surveillance (NOMS) system, a matched case-control design was employed to examine each of several diseases (including silicosis, lung cancer, stomach cancer, oesophageal cancer, COPD, pulmonary tuberculosis, sarcoidosis, systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and various types of renal disease). Cases were subjects whose death certificate mentioned the disease of interest. A separate control group for each of the diseases of interest was selected from among subjects whose death certificate did not mention the disease of interest or any of several diseases reported to be associated with crystalline silica exposure. Subjects were assigned into a qualitative crystalline silica exposure category based on the industry/occupation pairing found on their death certificate. We also investigated whether silicotics had a higher risk of disease compared to those without silicosis.Results:Those postulated to have had detectable crystalline silica exposure had a significantly increased risk for silicosis, COPD, pulmonary tuberculosis, and rheumatoid arthritis. In addition, a significant trend of increasing risk with increasing silica exposure was observed for these same conditions and for lung cancer. Those postulated to have had the greatest crystalline silica exposure had a significantly increased risk for silicosis, lung cancer, COPD, and pulmonary tuberculosis only. Finally, those with silicosis had a significantly increased risk for COPD, pulmonary tuberculosis, and rheumatoid arthritis.Conclusions:This study corroborates the association between crystalline silica exposure and silicosis, lung cancer, COPD, and pulmonary tuberculosis. In addition, support is provided for an association between crystalline silica exposure and rheumatoid arthritis.

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Male systemic sclerosis and occupational silica exposure—a population‐based study

Cited by 46 publications

References 5 publications

Occupational silica exposure as a risk factor for scleroderma: a meta-analysis

Occupational silica exposure as a risk factor for scleroderma: a meta-analysis

Environmental risk factors of systemic sclerosis

Occupational silica exposure and risk of various diseases: an analysis using death certificates from 27 states of the United States

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