Male-specific restriction of recombination frequency in the 
sex chromosomes of the medaka, <i>Oryzias latipes</i>

Matsuda, Masaru; Sotoyama, Saemi; Hamaguchi, Satoshi; Sakaizumi, Mitsuru

doi:10.1017/s0016672399003754

Cited by 69 publications

(42 citation statements)

References 12 publications

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“…No recombination between SD and DMRT1Y was detected (Fig. 1g), whereas all earlier described markers map with some distance left and right to SD (8,24). Thus DMRT1Y and the male SD colocalize on the genetic map (linkage Ͻ0.24 cM, equivalent to approximately 125 kb according to refs.…”

Section: Resultsmentioning

confidence: 58%

“…In fact, sex chromosomal crossing-over occurs over the entire length of the chromosome, with the possible exception of the region immediately adjacent to SD on the Y chromosome where an extremely high density of markers could not be ordered because of lack of detectable recombination (7,8,24). Linkage group 1, which contains SD, is the largest one and is equivalent to one pair of homomorphic chromosomes of the largest group.…”

Section: Discussionmentioning

confidence: 99%

“…A sex-reversed XY female backcross panel was generated as reported (8). A total of 117 backcross progeny were analyzed for four STS markers (Yc-2, Casp6, SL1, Casp3B) that were previously isolated (7,8,24) and two phenotypic markers (lf: leucophore, y: male sex). DMRT1Y was mapped by PCR using primers DMTk and DMTn (TGA TGC AGC ATT TTG ACA CAT TTA).…”

Section: Methodsmentioning

confidence: 99%

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A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

Nanda

Kondo

Hornung

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

799

628

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The genes that determine the development of the male or female sex are known in Caenorhabditis elegans, Drosophila, and most mammals. In many other organisms the existence of sex-determining factors has been shown by genetic evidence but the genes are unknown. We have found that in the fish medaka the Y chromosome-specific region spans only about 280 kb. It contains a duplicated copy of the autosomal DMRT1 gene, named DMRT1Y. This is the only functional gene in this chromosome segment and maps precisely to the male sex-determining locus. The gene is expressed during male embryonic and larval development and in the Sertoli cells of the adult testes. These features make DMRT1Y a candidate for the medaka male sex-determining gene.

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Section: Resultsmentioning

confidence: 58%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

Nanda

Kondo

Hornung

et al. 2002

Proc. Natl. Acad. Sci. U.S.A.

799

628

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“…Differences in meiotic recombination frequencies depending on phenotypic sex have been described in medaka fish (Yamamoto 1961;Matsuda et al 1999;Kondo et al 2001), where the recombination frequencies on the sex chromosomes of normal and sex-reversed individuals showed a clear correlation with their phenotypic sex. Irrespective of their sex chromosomal genotypes, phenotypic males displayed a lower recombination frequency on the sex chromosomes than phenotypic females did.…”

Section: Discussionmentioning

confidence: 97%

Linkage Analysis Reveals the Independent Origin of Poeciliid Sex Chromosomes and a Case of Atypical Sex Inheritance in the Guppy (Poecilia reticulata)

et al. 2009

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Among different teleost fish species, diverse sex-determining mechanisms exist, including environmental and genetic sex determination, yet chromosomal sex determination with male heterogamety (XY) prevails. Different pairs of autosomes have evolved as sex chromosomes among species in the same genus without evidence for a master sex-determining locus being identical. Models for evolution of Y chromosomes predict that male-advantageous genes become linked to a sex-determining locus and suppressed recombination ensures their co-inheritance. In the guppy, Poecilia reticulata, a set of genes responsible for adult male ornaments are linked to the sex-determining locus on the incipient Y chromosome. We have identified .60 sex-linked molecular markers to generate a detailed map for the sex linkage group of the guppy and compared it with the syntenic autosome 12 of medaka. We mapped the sex-determining locus to the distal end of the sex chromosome. We report a sex-biased distribution of recombination events in female and male meiosis on sex chromosomes. In one mapping cross, we observed sex ratio and male phenotype deviations and propose an atypical mode of genetic sex inheritance as its basis.

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“…Thus, it is likely that some meiosis-specific checkpoints are active in oogenesis but silent in spermatogenesis, and vice versa. In this context, it is notable that sex chromosome recombination is suppressed during medaka spermatogenesis regardless of the chromosomal condition; even in sex-reversed XX males, sex chromosome recombination is suppressed as it is in the XY male (Matsuda et al, 1999). Probably, gamete-type-specific activation of checkpoints and regulation of meiotic recombination are related to this phenomenon.…”

Section: Meiotic Checkpoint Differs In Females and Malesmentioning

confidence: 99%

Production of Diploid Eggs through Premeiotic Endomitosis in the Hybrid Medaka between Oryzias latipes and O. curvinotus

et al. 2000

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ABSTRACT-A hybrid medaka between Oryzias latipes and O. curvinotus spawns diploid eggs. We examined the cytological mechanisms of diploid egg formation in this hybrid. Oocytes in the hybrid passed through the first and second meiotic divisions and excluded two polar bodies, associated with reduction of the DNA content in oocytes. Each germinal vesicle in vitellogenic oocytes of the hybrid had 48 chromosomes with bivalent chiasmata, precisely twice the number of chromosomes in normal oocytes. These results suggest that before meiosis the chromosomes are doubled by mitosis without cytokinesis, that is, endomitosis, and that the resulting tetraploid oogonia undergo normal meiosis to produce diploid eggs. Except for a few vitellogenic oocytes that are probably derived from endomitotic oogonia, most oocytes were arrested at the zygotene stage in the hybrid ovary, suggesting the existence of checkpoint control that ensures the pairing of homologous chromosomes at prophase I, a situation differing from that in the male in which the checkpoint is at metaphase I. A sac-like structure was characteristic of the hybrid ovary. Although this structure was observed only in the hybrid, it may be a native component of the medaka ovary but difficult to observe because of its deformed outer structure due to enlargement of the inside oocytes. The present study confirms that this hybrid medaka provides a useful experimental system for investigations into the mechanisms of oogenesis and basic architecture of the ovary, which are difficult to analyze by using normal medaka.

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Male-specific restriction of recombination frequency in the sex chromosomes of the medaka, Oryzias latipes

Cited by 69 publications

References 12 publications

A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

A duplicated copy of DMRT1 in the sex-determining region of the Y chromosome of the medaka, Oryzias latipes

Linkage Analysis Reveals the Independent Origin of Poeciliid Sex Chromosomes and a Case of Atypical Sex Inheritance in the Guppy (Poecilia reticulata)

Production of Diploid Eggs through Premeiotic Endomitosis in the Hybrid Medaka between Oryzias latipes and O. curvinotus

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