Male secretory breast cancer: case in a 6-year-old boy with a peculiar gene duplication and review of the literature

Ghilli, Matteo; Mariniello, Maria Donatella; Scatena, Cristian; Dosa, Laura; Traficante, Giovanna; Tamburini, Angela; Caporalini, Chiara; Buccoliero, Annamaria; Facchini, Flavio; Colizzi, Livio; Li, A. Quattrini; Landucci, Elisabetta; Manca, G; Naccarato, Antonio Giuseppe; Caramella, Davide; Favre, C.; Roncella, Manuela

doi:10.1007/s10549-018-4772-4

Cited by 11 publications

(15 citation statements)

References 74 publications

(204 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The average age at presentation is 53 years (3–87 years). It mainly occurs in females [ 11 ] but has also been reported in males, summarized by Ghilli et al [ 127 ], in whom it may exhibit a more aggressive clinical course [ 128 ]. A similar tumour type may be seen in salivary glands (previously referred to as mammary analogue secretory carcinoma, MASC) and occasionally in the thyroid gland, skin and respiratory tract [ 129 ].…”

Section: Secretory Carcinoma (Sc)mentioning

confidence: 99%

“…Since the description of the initial series by McDivitt and Stewart, several hundred SCs have been reported, mostly as single case reports, small single institutional series and two larger database analyses [ 138 , 139 ]. These are summarized in Supplementary Table S6 [ 124 , 125 , 127 , 129 , 130 , 131 , 132 , 138 , 139 , 140 , 141 , 142 , 143 , 144 , 145 , 146 , 147 , 148 ]. In 2018, Garlick reviewed 89 cases previously published and these are included in the table on the basis of his review [ 144 ].…”

Section: Secretory Carcinoma (Sc)mentioning

confidence: 99%

See 1 more Smart Citation

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Cserni

Quinn

Foschini

et al. 2021

Cancers

View full text Add to dashboard Cite

Triple-negative breast cancers (TNBC), as a group of tumours, have a worse prognosis than stage-matched non-TNBC and lack the benefits of routinely available targeted therapy. However, TNBC is a heterogeneous group of neoplasms, which includes some special type carcinomas with a relatively indolent course. This review on behalf of the European Working Group for Breast Screening Pathology reviews the literature on the special histological types of BC that are reported to have a triple negative phenotype and indolent behaviour. These include adenoid cystic carcinoma of classical type, low-grade adenosquamous carcinoma, fibromatosis-like metaplastic carcinoma, low-grade mucoepidermoid carcinoma, secretory carcinoma, acinic cell carcinoma, and tall cell carcinoma with reversed polarity. The pathological and known molecular features as well as clinical data including treatment and prognosis of these special TNBC subtypes are summarised and it is concluded that many patients with these rare TNBC pure subtypes are unlikely to benefit from systemic chemotherapy. A consensus statement of the working group relating to the multidisciplinary approach and treatment of these rare tumour types concludes the review.

show abstract

Section: Secretory Carcinoma (Sc)mentioning

confidence: 99%

Section: Secretory Carcinoma (Sc)mentioning

confidence: 99%

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Cserni

Quinn

Foschini

et al. 2021

Cancers

View full text Add to dashboard Cite

show abstract

“…As presented in a study by Ghilli [ 25 ], secretory breast cancer (SBC) is one of the rarest forms of breast cancer (BC), accounting for the vast majority of BC in children. Nonetheless, it generates a great deal of interest due to its peculiar morphology and genetic characteristics.…”

Section: Resultsmentioning

confidence: 99%

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

et al. 2022

View full text Add to dashboard Cite

Male breast cancers are uncommon, as men account for less than 1 percent of all breast carcinomas. Among the predisposing risk factors for male breast cancer, the following appear to be significant: (a) breast/chest radiation exposure, (b) estrogen use, diseases associated with hyper-estrogenism, such as cirrhosis or Klinefelter syndrome, and (c) family health history. Furthermore, there are clear familial tendencies, with a higher incidence among men who have a large number of female relatives with breast cancer and (d) major inheritance susceptibility. Moreover, in families with BRCA mutations, there is an increased risk of male breast cancer, although the risk appears to be greater with inherited BRCA2 mutations than with inherited BRCA1 mutations. Due to diagnostic delays, male breast cancer is more likely to present at an advanced stage. A core biopsy or a fine needle aspiration must be performed to confirm suspicious findings. Infiltrating ductal cancer is the most prevalent form of male breast cancer, while invasive lobular carcinoma is extremely uncommon. Male breast cancer is almost always positive for hormone receptors. A worse prognosis is associated with a more advanced stage at diagnosis for men with breast cancer. Randomized controlled trials which recruit both female and male patients should be developed in order to gain more consistent data on the optimal clinical approach.

show abstract

“…Breast secretory carcinoma is a slowgrowing, low-grade subtype of infiltrating ductal carcinoma. The disease seems slightly more aggressive in adults (Vasudev and Onuma 2011;Ghilli et al, 2018).…”

Section: Breast Ductal Carcinoma -Secretory Breast Carcinoma Subtype mentioning

confidence: 96%

t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors

Huret¹

2020

Atlas of Genetics and Cytogenetics in Oncology and Haematology

View full text Add to dashboard Cite

show abstract

Male secretory breast cancer: case in a 6-year-old boy with a peculiar gene duplication and review of the literature

Abstract: SBC is a rare type of BC, characterized by triple-negative features with an unexpectedly good prognosis. More data are needed to fully understand the behavior of this cancer and genomic profiling could be helpful in improving its diagnosis and management.

Cited by 11 publications

References 74 publications

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

Triple-Negative Breast Cancer Histological Subtypes with a Favourable Prognosis

An Update on the General Features of Breast Cancer in Male Patients—A Literature Review

t(12;15)(p13;q25) ETV6/NTRK3 in solid tumors

Contact Info

Product

Resources

About