Male reproductive system

Ramirez-Gonzalez, J.A.; Sansone, Andrea

doi:10.1016/b978-0-12-818309-0.00006-x

Cited by 2 publications

(2 citation statements)

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“…The testicular surface is covered by the tunica albuginea, with a thickness of 1 to 2 mm, composed of collagen fibers and containing the blood vessels (testicular artery and testicular vein) that are visible on the testicular surface, in which each species present a characteristic pattern ( 49 , 50 ). Regarding muscle constitution, the testis is covered by the smooth muscle dartos tunic and suspended by the cremaster muscle, which contribute to testicular thermoregulation, moving the gonads away or closer to the inguinal-abdominal area ( 51 ). This mechanism is related to testicular temperature maintenance, which is essential for spermatogenesis to occur normally.…”

Section: Testicular Morphophysiologymentioning

confidence: 99%

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Biomaterials for Testicular Bioengineering: How far have we come and where do we have to go?

et al. 2023

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Traditional therapeutic interventions aim to restore male fertile potential or preserve sperm viability in severe cases, such as semen cryopreservation, testicular tissue, germ cell transplantation and testicular graft. However, these techniques demonstrate several methodological, clinical, and biological limitations, that impact in their results. In this scenario, reproductive medicine has sought biotechnological alternatives applied for infertility treatment, or to improve gamete preservation and thus increase reproductive rates in vitro and in vivo. One of the main approaches employed is the biomimetic testicular tissue reconstruction, which uses tissue-engineering principles and methodologies. This strategy pursues to mimic the testicular microenvironment, simulating physiological conditions. Such approach allows male gametes maintenance in culture or produce viable grafts that can be transplanted and restore reproductive functions. In this context, the application of several biomaterials have been proposed to be used in artificial biological systems. From synthetic polymers to decellularized matrixes, each biomaterial has advantages and disadvantages regarding its application in cell culture and tissue reconstruction. Therefore, the present review aims to list the progress that has been made and the continued challenges facing testicular regenerative medicine and the preservation of male reproductive capacity, based on the development of tissue bioengineering approaches for testicular tissue microenvironment reconstruction.

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Section: Testicular Morphophysiologymentioning

confidence: 99%

“…This mechanism is related to testicular temperature maintenance, which is essential for spermatogenesis to occur normally. In species that the testis are inside the scrotum, the temperature of the gonads must be between 4° and 7° C below body temperature ( 51 , 52 ).…”

Section: Testicular Morphophysiologymentioning

confidence: 99%