Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females—Additive Effect of Postweaning Diet

Tajaddini, Aynaz; Kendig, Michael D.; Prates, Kelly Valério; Westbrook, R. Frederick; Morris, Margaret J.

doi:10.3390/ijms23031442

Cited by 24 publications

(26 citation statements)

References 64 publications

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“…We observed that adult male offspring from HC-CP mothers had higher body weights and food intakes than offspring from CON mothers, confirming that maternal obesity can increase the risk of obesity in offspring, at least in males. This sex-specific response has been observed in some [ 45 , 46 ], but not all [ 47 , 48 ], previous rodent model studies investigating the transgenerational impact of maternal obesity. Chang et al (2019) reported that male mouse offspring born to mothers fed a high-fat diet before conception had greater weight gain and subcutaneous adipose mass compared with their female counterparts when exposed to a postnatal high-fat diet challenge [ 49 ].…”

Section: Discussionmentioning

confidence: 71%

Maternal Pea Protein Intake Provides Sex-Specific Protection against Dyslipidemia in Offspring from Obese Pregnancies

et al. 2023

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Increased consumption of dietary pulse protein has been shown to assist in body weight regulation and improve a range of metabolic health outcomes. We investigated if the exchange of casein for yellow pea protein (YPPN) in an obese-inducing maternal diet throughout pregnancy and lactation offered protection against obesity and dyslipidemia in offspring. Sixty female Sprague Dawley rats were fed a low-calorie control diet (CON), a high-caloric obesity-inducing diet (with casein protein (CP), HC-CP), or an isocaloric/macronutrient-matched HC diet supplemented with YPPN isolate (HC-PPN) in pre-pregnancy, gestation, and lactation. Body weight (BW) and metabolic outcomes were assessed in male and female offspring at weaning and in adulthood after consuming the CON diet in the postnatal period. Consumption of the HC-PPN diet did not protect against maternal obesity but did improve reproductive success compared with the HC-CP group (72.7% versus 43.7%) and reduced total energy, fat, and protein in maternal milk. Male, but not female, offspring from mothers fed the HC-CP diet demonstrated hyperphagia, obesity, dyslipidemia, and hepatic triglyceride (TG) accumulation as adults compared with CON offspring. Isocaloric exchange of CP for YPPN in a high-calorie obese-inducing diet did not protect against obesity but did improve several aspects of lipid metabolism in adult male offspring including serum total cholesterol, LDL/VLDL cholesterol, triglycerides (TGs), and hepatic TG concentration. Our results suggest that the exchange of CP for YPPN in a maternal obese-inducing diet selectively protects male offspring from the malprogramming of lipid metabolism in adulthood.

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Section: Discussionmentioning

confidence: 71%

Maternal Pea Protein Intake Provides Sex-Specific Protection against Dyslipidemia in Offspring from Obese Pregnancies

et al. 2023

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“…Full details of this cohort were reported in our previous study. [ 29 ] Briefly, females were fed Chow ( n = 15, mean weight = 213 ± 2 g [SEM]) or Caf ( n = 21, 217 ± 1 g) diets for 6 weeks, then mated with chow‐fed males. Litters were standardized to 6‐male and 6‐female pups, where possible.…”

Section: Methodsmentioning

confidence: 99%

“…*Data from siblings reported previously. [29] to the other diet (groups CCaf and CafC). At 22 weeks of age, rats in the ChowCaf and CafCaf groups were switched to the chow diet for a further 5 weeks.…”

Section: Introductionmentioning

confidence: 99%

The Benefits of Switching to a Healthy Diet on Metabolic, Cognitive, and Gut Microbiome Parameters Are Preserved in Adult Rat Offspring of Mothers Fed a High‐Fat, High‐Sugar Diet

Kendig

Hasebe

Tajaddini

et al. 2022

Molecular Nutrition Food Res

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Scope: Maternal obesity increases the risk of health complications in children, highlighting the need for effective interventions. A rat model of maternal obesity to examine whether a diet switch intervention could reverse the adverse effects of an unhealthy postweaning diet is used. Methods and results: Male and female offspring born to dams fed standard chow or a high-fat, high-sugar "cafeteria" (Caf ) diet are weaned onto chow or Caf diets until 22 weeks of age, when Caf-fed groups are switched to chow for 5 weeks. Adiposity, gut microbiota composition, and place recognition memory are assessed before and after the switch. Body weight and adiposity fall in switched groups but remain significantly higher than chow-fed controls. Nonetheless, the diet switch improves a deficit in place recognition memory observed in Caf-fed groups, increases gut microbiota species richness, and alters 𝜷 diversity. Modeling indicate that adiposity most strongly predicts gut microbiota composition before and after the switch. Conclusion: Maternal obesity does not alter the effects of switching diet on metabolic, microbial, or cognitive measures. Thus, a healthy diet intervention lead to major shifts in body weight, adiposity, place recognition memory, and gut microbiota composition, with beneficial effects preserved in offspring born to obese dams.

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“…The impact of developmental programming due to maternal obesity differs by sex of the offspring in rodent models. Male offspring, compared to female offspring, show greater body weight, retroperitoneal fat mass, liver mass, plasma leptin levels, and impaired glucose tolerance [ 87 , 88 ]. Furthermore, male offspring have decreased islet number and secretion at postnatal day 21 compared to female offspring [ 89 ] ( Figure 1 ).…”

Section: Introductionmentioning

confidence: 99%

Diet Modification before or during Pregnancy on Maternal and Foetal Outcomes in Rodent Models of Maternal Obesity

et al. 2022

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The obesity epidemic has serious implications for women of reproductive age; its rising incidence is associated not just with health implications for the mother but also has transgenerational ramifications for the offspring. Increased incidence of diabetes, cardiovascular disease, obesity, and kidney disease are seen in both the mothers and the offspring. Animal models, such as rodent studies, are fundamental to studying maternal obesity and its impact on maternal and offspring health, as human studies lack rigorous controlled experimental design. Furthermore, the short and prolific reproductive potential of rodents enables examination across multiple generations and facilitates the exploration of interventional strategies to mitigate the impact of maternal obesity, both before and during pregnancy. Given that obesity is a major public health concern, it is important to obtain a greater understanding of its pathophysiology and interaction with reproductive health, placental physiology, and foetal development. This narrative review focuses on the known effects of maternal obesity on the mother and the offspring, and the benefits of interventional strategies, including dietary intervention, before or during pregnancy on maternal and foetal outcomes. It further examines the contribution of rodent models of maternal obesity to elucidating pathophysiological pathways of disease development, as well as methods to reduce the impact of obesity on the mothers and the developing foetus. The translation of these findings into the human experience will also be discussed.

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Male Rat Offspring Are More Impacted by Maternal Obesity Induced by Cafeteria Diet than Females—Additive Effect of Postweaning Diet

Cited by 24 publications

References 64 publications

Maternal Pea Protein Intake Provides Sex-Specific Protection against Dyslipidemia in Offspring from Obese Pregnancies

Maternal Pea Protein Intake Provides Sex-Specific Protection against Dyslipidemia in Offspring from Obese Pregnancies

The Benefits of Switching to a Healthy Diet on Metabolic, Cognitive, and Gut Microbiome Parameters Are Preserved in Adult Rat Offspring of Mothers Fed a High‐Fat, High‐Sugar Diet

Diet Modification before or during Pregnancy on Maternal and Foetal Outcomes in Rodent Models of Maternal Obesity

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