Male priming pheromone is present in bile, as well as urine, of female rainbow trout

Scott, Alexander P.

doi:10.1006/jfbi.2000.1508

Cited by 7 publications

(9 citation statements)

References 15 publications

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“…This latter topic is discussed in detail in Section 5.2.2. Steroid conjugation may be important in the production of pheromones as was mentioned previously for androgens, but there is also evidence that progesterone conjugates may function as pheromones as well (Vermeirssen and Scott 2001). …”

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confidence: 77%

“…For some chemicals, urinary or biliary excretion can be the most important elimination pathway (Guarino and Anderson 1976;Pritchard and Bend 1991). Conjugation with glucoronide or sulfate and subsequent excretion in bile and urine is known to be an important elimination route for natural and synthetic steroids (Truscott 1983;Schultz et al 2001;Vermeirssen and Scott 2001). For many chemicals, biotransformation is not only important as an elimination pathway but also in bioactivation to more toxicologically potent forms.…”

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confidence: 99%

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Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances

2004

OECD Series on Testing and Assessment

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LIST OF TABLES ACKNOWLEDGMENTSThe OECD Secretariat would like to acknowledge the contributions of national experts who provided extensive comments on the draft version of this detailed review paper:• US Environmental Protection Agency, Office of Science Coordination and Policy, who prepared the original version of this document; • Brunel University, Department Biological Sciences, United Kingdom;• US Environmental Protection Agency, Mid-Continent Ecology Division (Duluth, MN);• University of Heidelberg, Zoological Institute, Aquatic Ecotoxicology, Germany;• Fraunhofer Institute for Molecular Biology and Applied Ecology (Schmallenberg) Germany;• ECT Ecotoxicology (Flörsheim), Germany;• Laboratory for Aquatic Organisms, Bayer CropScience (Monheim), Germany;• DHI Water & Environment, Environmental Risk Assessment (Hørsholm), Denmark, who assisted the OECD Secretariat in finalising the Detailed Review Paper; • Schering AG, Experimental Toxicology (Berlin), Germany;• University of Southern Denmark, Institute of Biology (Odenske), Denmark;• European Commission, ECB European Chemicals Bureau (Ispra) Italy;• Institut National de l'Environnement Industriel et des Risques (Verneuil-en-Halatte), France;• CEFAS -Centre for Environment Fisheries and Aquaculture Science, United Kingdom;• Department of the Army Corps of Engineers, United States;• Waterways Experiment Station, Environmental Laboratory (Vicksburg/MS, US). ENV/JM/MONO(2004)18 13 PREAMBLEIn 1998, a Task Force on Endocrine Disrupter Testing and Assessment (EDTA) was established at the request of OECD member countries. The EDTA Task Force is a Special Activity of the Test Guidelines Programme and its main objectives are to:identify the needs and prioritize the development of new and enhanced guidelines for the detection and characterization of endocrine disrupting chemicals;• develop a harmonized testing strategy for the screening and testing of endocrine disrupters;• manage validation work for newly developed and enhanced Test Guidelines as appropriate;and, • provide practical tools for sharing testing results and assessments.The need for new and updated test methods to detect and characterise endocrine disrupting chemicals has been expressed by the Task Force for the assessment of human health effects and environmental effects. At early meetings of the EDTA Task Force, it appeared that existing OECD Test Guidelines would insufficiently cover for endocrine-related effects, especially for the environment. Member countries decided to list test methods which could potentially cover effects of chemicals on the reproductive system (estrogen agonists/antagonists and androgen agonists/antagonists) and on the development (thyroid system), and proposed enhancements where needed. Fish screening assays have been developed for the detection of (anti-) estrogenic and (anti-)androgenic compounds in oviparous animals living in aquatic ecosystems, as there is good evidence that fish in the field are being impacted by endocrine active substances. This Detailed Review Paper (DRP) is...

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confidence: 77%

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confidence: 99%

Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances

2004

OECD Series on Testing and Assessment

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“…This finding is supported by Murphy et al (2001), who showed that 19 of 144 synthetic steroids induced an EOG response in round gobies. Of these compounds, conjugated steroids (e.g., ETIO-g), which are more soluble in water than unconjugated steroids (e.g., ETIO), are more likely to be used in pheromone signaling (Scott and Vermeirssen 1994;Vermeirssen and Scott 1996).…”

Section: Discussionmentioning

confidence: 99%

Evidence of a Male Sex Pheromone in the Round Goby (Neogobius melanostomus)

et al. 2006

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The reproductive success of the round goby (Neogobius melanostomus), an invasive fish, may be mediated by the use of pheromones. We hypothesized that reproductive male (RM) round gobies release a sex pheromone to which reproductive females (RF) respond. In this study, we compared behavioural and electrophysiological responses of reproductive and non-reproductive female round gobies to conspecific males. Results of behavioural experiments in the laboratory showed that RF spent significantly more time near the source of the male odour compared with odours from control water. However, RF did not distinguish between odours from non-reproductive male (non-RM) water and control water. Non-reproductive females (non-RF) were not attracted to odours released from RM or non-RM water. Results of electro-olfactogram (EOG) responses showed that both RF and non-RF discriminated between HPLC fractionated RM and non-RM odours. However, the EOG responses of RF were about eight-fold higher than non-RF exposed to RM odours. These findings confirm that RM round gobies release a pheromone signal that attracts RF. The results of this research may be useful in developing a control strategy using natural pheromones to disrupt the reproductive behaviour of the invasive round goby and to curtail its effects on native species.

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“…Bile acids are known to act as potent odorants for teleosts (Hara, 1994;Zhang et al, 2001;Giaquinto & Hara, 2008), and conspecific bile fluid has been shown to have pheromonal activity for some fish species (Vermeirssen & Scott, 2001;Huertas et al, 2007). Two lines of evidence suggest that the odorants contained in the bile fluid are likely to be mainly bile acids.…”

Section: Introductionmentioning

confidence: 99%

“…For instance, behavioral evidence suggests that one of their functions as olfactory stimulants is their role as pheromones for migratory anadromous fishes, some of which appear to recognize and select the odor of conspecifics when choosing spawning streams (Doving et al, 1980;Stabell, 1992). Recently, it has been shown that bile acid profiles of lake trout (Salvelinus namaycush) are largely influenced by sex and maturation stage (Zhang et al, 2001) and that bile of female Rainbow trout (Oncorhynchus mykiss) contains a pheromone (Vermeirssen & Scott, 2001). Moreover, malespecific bile acids of sea lamprey (Petromyzon marinus) are potent and specific stimulants to the female olfactory organ (Siefkes & Li, 2004).…”

Section: Introductionmentioning

confidence: 99%

Bile acids as potential pheromones in pintado catfish Pseudoplatystoma corruscans (Spix & Agassiz, 1829): eletrophysiological and behavioral studies

et al. 2015

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Bile acids are potent olfactory and gustatory stimulants for fish. Electro-olfactogram recording was used to test whether the olfactory epithelium of pintado catfish Pseudoplatystoma corruscans is specifically sensitive to bile acids, some of which have been hypothesized to function as pheromones. Five out of 30 bile acids that had been pre-screened for olfactory activity in fish were selected. Cross-adaptation experiments demonstrated that sensitivity to bile acids is attributable to at least 3 independent classes of olfactory receptor sites. The taurocholic acid (TCA) and taurochenodeoxycholic acid (TCD) were the most potent compounds. By using avoidance/preference tests, we found that P. corruscans prefers water containing TCA. Bile acids are discriminated by olfactory epithelium of pintado, supporting that these compounds could function as pheromones.Os ácidos biliares são potentes estimulantes olfatórios e gustatórios em peixes. Registros em eletro-olfactograma foram usados para testar se o epitélio olfatório de Pseudoplatystoma corruscans, pintado, é sensível aos ácidos biliares, alguns dos quais têm sido propostos como feromônios. Foram selecionados cinco de uma lista de trinta ácidos biliares previamente testados em atividade olfatória em peixes. Testes de adaptação cruzada demonstraram que a sensibilidade aos ácidos biliares se dá por 3 classes independentes de sites de receptores olfatórios. O ácido taurocólico (TCA) e o ácido tauroquenodesoxicólico (TCD) foram os compostos mais potentes. Em testes de evasão/preferência, P. corruscans prefere água contendo o ácido TCA. Os ácidos biliares são discriminadas por epitélio olfatório de pintado, evidenciando que estes compostos podem funcionar como feromônios.

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Male priming pheromone is present in bile, as well as urine, of female rainbow trout

Cited by 7 publications

References 15 publications

Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances

Detailed Review Paper on Fish Screening Assays for the Detection of Endocrine Active Substances

Evidence of a Male Sex Pheromone in the Round Goby (Neogobius melanostomus)

Bile acids as potential pheromones in pintado catfish Pseudoplatystoma corruscans (Spix & Agassiz, 1829): eletrophysiological and behavioral studies

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