Male papillomavirus infection and genotyping in the Qingyuan area

Yin, Wen; Yang, Meng; Peng, Lei; Liu, Yanmei; Cheng, Bin; Xuan, Shuxia; Chen, Chen; Tan, Feng-Jun

doi:10.1186/s12985-020-01423-w

Cited by 7 publications

(8 citation statements)

References 23 publications

(27 reference statements)

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“…Our study found that 82.22% (1,336/1,625) of the cases had an age distribution of ≤ 24, 25–34, and 35–44, which may be related to the level of sexual activity. This study found no significant difference in HPV detection rates among different age groups, which is different from a previous study of high-risk male HPV infected individuals ( Yin et al, 2020 ), This may be related to the fact that the research subjects of this study are male and female patients with genital warts. In addition, long-term and persistent HPV infection may pose a risk of cancer transformation, so it is necessary to conduct comprehensive and regular screening for elderly people infected with HPV ( Sudenga et al, 2017 ).…”

Section: Discussioncontrasting

confidence: 99%

Evaluation of HPV infection and presence of licensed HPV vaccine genotypes among genital warts in Foshan, China

Huang,

Yao,

Zou

et al. 2024

Front. Microbiol.

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ObjectiveThis study aimed to evaluate the prevalence of human papillomavirus (HPV) infection and presence of licensed HPV vaccine genotypes among patients with genital warts in Foshan, China from 2015 to 2022, to provide useful references for the detection, prevention and control of genital warts in Foshan.MethodsThe present study retrospectively analyzed the HPV detection rates in patients with genital warts. A total of 1,625 patients were seen at the Second People’s Hospital of Foshan, Guangdong Province, China, from 2015 to 2022. Samples were collected from various lesions and genotyped for 21 genotypes of HPV by infusion hybridization. The classification principle of HPV genotypes in this study: (1) Based on the relationship between HPV and carcinogenicity; (2) Based on the number of HPV genotypes infected; (3) Based on the HPV genotypes of licensed HPV vaccines.ResultsThe detection rate of any HPV in patients with genital warts was 80.37% (1,306/1,625). The detection rates of HPV for low-risk infection, co-infection and high-risk infection were 49.48% (804/1,625), 24.92% (405/1,625) and 5.97% (97/1,625), respectively. Single infection was the predominant type (51.94%, 844/1625). HPV-6 and HPV-11 were the predominant types of single infection; HPV-6 and HPV-52 were the predominant types of paired combinations of multiple infection. 82.22% (1,336/1,625) of the cases had an age distribution of ≤ 24, 25–34, and 35–44. The distribution of some HPV genotypes had age specificity, annual specificity and gender specificity. The genotype detection rates of 2v, 4v and 9v showed a decreasing trend with ages (all P < 0.05). The genotype detection rates of 4v and 9v showed a decreasing trend over the 8-year period (both P < 0.05). The genotype detection rates of 4v and 9v in the male group were higher than those in the female group (both P < 0.05). The genotype detection rate of 9v was significantly higher than that of 2v and 4v in the female group (both P < 0.05).ConclusionOur study demonstrated that low-risk infection and single infection were the main types of HPV infection in patients with genital warts, mainly among young patients. Our study provides epidemiological data for the detection, prevention and control of genital warts in China.

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Section: Discussioncontrasting

confidence: 99%

Evaluation of HPV infection and presence of licensed HPV vaccine genotypes among genital warts in Foshan, China

Huang,

Yao,

Zou

et al. 2024

Front. Microbiol.

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“…The top five HPV genotypes were HPV-52, HPV-58, HPV-16, HPV-51, and HPV-66, which was consistent with the data generated by some Chinese population-specific investigations [ 4 , 10 , 11 ]. A study conducted in Guangdong Province, China showed that the top five prevalence of high-risk HPV genotypes among males were HPV-16, HPV-18, HPV-31, HPV-33, and HPV-35 [ 10 ]. Another study conducted in southern China showed that the most common HPV genotypes among males were HPV-58, HPV-52, and HPV-16 [ 11 ].…”

Section: Discussionsupporting

confidence: 90%

“…HPV infection among male has significantly increased the risk of cervical cancer in their sexual partners [ 4 , 10 , 11 ]. Although the majority of men with HPV infection were asymptomatic or subclinical cases, HPV still caused malignant diseases such as anal or penile cancer in men [ 12 , 13 ].…”

Section: Introductionmentioning

confidence: 99%

Detecting and genotyping high-risk human papillomavirus among male patients during 2015–2023 in Beijing, China

Wang,

Ma,

et al. 2024

Emerging Microbes & Infections

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Few studies focused on human papillomavirus (HPV) in male patients. This study aimed to explore the detection rate and genotyping of HPV among male patients in Beijing to provide a reference for formulating prevention strategies for HPV infection. The cross-sectional study was conducted in Beijing Chaoyang Hospital from November 2015 to March 2023. It covered male patients from the urology and dermatology departments. Fifteen high-risk HPV genotypes were detected by the multiplex real-time polymerase chain reaction method. The overall detection rate of HPV was 25.19% (1288/5114, 95% confidence interval [CI] 24.00%−26.38%), of which the single infection rate was 16.99% (869/5114, 95% CI 15.97%−18.05%) and the co-infection rate was 8.19% (419/5114, 95% CI 7.46%−8.98%). The detection rate of HPV was 40.77% (521/1278), 35.58% (58/163), 32.69% (101/309), 31.91% (60/188), 12.63% (299/2367), and 32.35% (131/405) among male patients with balanitis, warts, rash, urethritis, prostatitis, and other urinary inflammation, respectively ( P < 0.001). The top five HPV genotypes were HPV-52, HPV-58, HPV-16, HPV-51, and HPV-66. After the first positive HPV test, the proportion of male patients who turned negative was 22.47% within 3 months, 26.40% within 3−6 months, 24.72% within 6−12 months, 17.98% within 12−24 months, and 8.43% more than 24 months. The detection rate of HPV was high among male patients from the urology and dermatology departments in Beijing, which should be considered to develop HPV vaccines with better prevention effects.

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“…This retrospective study presents the inaugural estimate of genital HPV infection prevalence among outpatient men in Guangzhou, China, revealing an overall prevalence of 42.15% with variations ranging from 29.55% to 81.31% across distinct diagnostic populations. Comparisons with other regions in China indicate similarities with the 42.0% prevalence reported among men in Shandong, 18 but lower rates compared to Qingyuan (54.3%) 19 and Shanghai (58.4%), 20 and higher rates compared to Anyang (17.5%) 21 and Liuzhou (9.4%). 22 Additionally, a previous systematic review encompassing 65 HPV prevalence studies from 35 countries estimated the global overall HPV prevalence among men to be 31%, with study-specific prevalence varying widely from 1% to 84% among low-risk men and from 2% to 93% among high-risk men.…”

Section: Discussionsupporting

confidence: 55%

High burden of human papillomavirus infection among men in Guangzhou, South China: Implications for HPV vaccination strategies

Liu,

Yang,

Zhao

et al. 2024

Human Vaccines & Immunotherapeutics

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The epidemiological and clinical aspects of Human Papillomavirus (HPV) infection in women have been extensively studied. However, there is a lack of information regarding HPV characteristics in males. In this study, we conducted a retrospective and observational study of 3737 consecutive male individuals attending outpatient clinics of Guangdong Women and Children Hospital from 2012 to 2023 in Guangzhou, South China, to determine the age- and genotype-specific prevalence of HPV in men. The results showed the overall prevalence of HPV among men was 42.15% (1575/3737), with variations ranging from 29.55% to 81.31% across distinct diagnostic populations. Low-risk HPV6 (15.47%), HPV11 (8.94%), and high-risk HPV52 (5.51%) were the most common types. The annual HPV prevalence decreased significantly (Z = −3.882, p < .001), ranging from 31.44% to 52.90%. 28.77% (1075/3737) of men manifested infection with a singular HPV type, predominantly identified as a low-risk type. The age-specific distribution of HPV infections revealed distinctive peaks in the < 25 y age group (47.60%, 208/437) and the 40–44 y age group (44.51%, 154/346). Notably, the positive rate of Chlamydia trachomatis was significantly higher among HPV-positive individuals in comparison to HPV-negatives (16.14% vs. 11.25%, p < .05). Our findings reveal a substantial prevalence of HPV infection among outpatient men in Guangzhou, South China. It is recommended to consider the inclusion of HPV vaccination for adolescent males in national immunization schedules, once an adequate supply of vaccines is accessible.

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Male papillomavirus infection and genotyping in the Qingyuan area

Cited by 7 publications

References 23 publications

Evaluation of HPV infection and presence of licensed HPV vaccine genotypes among genital warts in Foshan, China

Evaluation of HPV infection and presence of licensed HPV vaccine genotypes among genital warts in Foshan, China

Detecting and genotyping high-risk human papillomavirus among male patients during 2015–2023 in Beijing, China

High burden of human papillomavirus infection among men in Guangzhou, South China: Implications for HPV vaccination strategies

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