Male overactive bladder: The role of urodynamics and anticholinergics

Abstract

Millions of men suffer from overactive bladder and lower urinary tract symptoms. The adverse effects on quality of life and costs associated with the condition have been well described. In men, the pathophysiology of lower urinary tract symptoms may be from a number of causes including bladder outlet obstruction, detrusor overactivity, or both. Increasing data and clinical experience support the efficacy and safety of anticholinergics in men; the rate of urinary retention has been equal to that of placebo in short-term studies. Urodynamics play a vital role in defining the bladder and/or outlet dysfunction and help direct one's therapy.

Safety and Tolerability of Solifenacin Add-on Therapy to α-Blocker Treated Men With Residual Urgency and Frequency

“…The International Consultation on Incontinence recommends pressure flow urodynamics in the evaluation of men when a precise diagnosis of BOO is important. 22 To our knowledge this is the only method that can differentiate men with a low peak flow rate due to detrusor underactivity from those with BOO.…”

Conducting Polymers Meet Lithium–Sulfur Batteries: Progress, Challenges, and Perspectives

“…They found that the electrical conductivity of polyacetylene (PA) could be significantly increased after doping with metal. [ 1–3 ] High conductivity mainly originated from the π electron migration, while it is restricted in most conjugated polymers due to the limited electrons transfer between π orbitals in the highly structured molecular chains. Introducing conductive heteroatoms into polymers can not only greatly improve their conductivity and redox activity by changing π orbitals and enhancing flexible electrons mobility on the molecular chain, [ 4–7 ] but also encourage the ability to capture and adsorb cations, improving the application potential.…”