“…Loss of function studies have revealed katanins are critical regulators of microtubule organisation in a wide range of cellular processes, including mitosis, cilia biogenesis, neurogenesis and spermatogenesis (Banks et al, 2018; Dunleavy et al, 2022; Dunleavy et al, 2021; Dunleavy et al, 2017; Hu et al, 2014; Lombino et al, 2019; Lynn et al, 2021; McNally and Roll-Mecak, 2018; Mishra-Gorur et al, 2014; O’Donnell et al, 2012; Smith et al, 2012). The loss of katanin activity in regulating the length and dynamics of microtubules leads to errors in cell division, shape, and migration (Buster et al, 2002; Lombino et al, 2019; O’Donnell et al, 2012; Smith et al, 2012).…”