Male Infertility in Humans: An Update on Non-obstructive Azoospermia (NOA) and Obstructive Azoospermia (OA)

Wu, Xiaolong; Lin, Dengfeng; Sun, Fei; Cheng, Chen

doi:10.1007/978-3-030-77779-1_8

Cited by 17 publications

(11 citation statements)

References 86 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…OA accounts for about 40% of all azoospermic cases, which can result from obstruction of the excurrent ducts at any location between the testis and the ejaculatory ducts. OA is usually defined as the normal spermatogenesis in the testis and normal endocrine levels (Wu et al, 2021) while NOA is a distinct diagnosis with no sperm found in the ejaculate as a result of spermatogenesis failure. The aetiology of OA is divided into acquired and congenital causes.…”

Section: Introductionmentioning

confidence: 99%

Clinical outcome of microsurgical vasoepididymostomy versus epididymal or testicular sperm retrieval combined with intracytoplasmic sperm injection in obstructive azoospermia males

Zhang

2022

Andrologia

View full text Add to dashboard Cite

This purpose of the retrospective study was to compare the clinical outcome of microsurgical vasoepididymostomy (MVE) and sperm retrieval combined with intracytoplasmic sperm injection (ICSI) in the treatment of males with obstructive azoospermia. From February 2018 to December 2019, a total of 69 males with obstructive azoospermia underwent MVE while 351 males with obstructive azoospermia in their first ICSI cycles were enrolled. Patients in the MVE group achieved higher pregnancy rate and births delivered rate than those in ICSI group (pregnancy rate, 44.6% vs. 27.6% for MVE and ICSI, respectively; delivery rate, 38.5% versus 25.8% for MVE and ICSI, respectively). Besides, lower female age (<35 vs. ≥35 years old, OR 1.15, 95% CI = 1.08-1.21), higher sperm concentration and forward motility after MVE((sperm concentration, OR (95% CI) = 1.12 (1.08-1.23), sperm forward motility, OR (95% CI) = 1.10 (1.06-1.20)) were associated with higher probability of pregnancy. Based on these data, it has been found that MVE is the prior option for males with obstructive azoospermia suitable for the surgery, other than direct subjected to ICSI. More high quality studies are needed in the future due to the nonrandomized design and the relative small size of this study.

show abstract

Section: Introductionmentioning

confidence: 99%

Clinical outcome of microsurgical vasoepididymostomy versus epididymal or testicular sperm retrieval combined with intracytoplasmic sperm injection in obstructive azoospermia males

Zhang

2022

Andrologia

View full text Add to dashboard Cite

show abstract

“…In addition, the miR-34 family members control the genes notch 1 (NOTCH1), notch 2 (NOTCH2), TGFB-induced factor homeobox 2 (TGIF2), cyclindependent kinase 4 (CDK4), MYC proto-oncogene, BHLH transcription factor (c-MYC), and miR-449, which controls NOTCH1 and Bcell lymphoma 2 (BCL2). 27,28 Together, these genes control the Both the let-7 family and miR-22 target the proteins high mobility group AT-hook 2 (Hmga2) and outer dense fiber of sperm tails 1 (ODF1), which are involved in the structural organization and development of germ cells in mice and humans, respectively. The let-7 family also targets insulin-like growth factor 1 (Igf1) and may regulate mouse spermatogonial development by activating PI3K and extracellular signal-regulated kinase 1/2 (Erk1/2).…”

Section: The Differentiation Of Male Sscs To Spermatocytesmentioning

confidence: 99%

Functions and mechanism of noncoding RNA in regulation and differentiation of male mammalian reproduction

Karoii

Azizi

2023

Cell Biochemistry & Function

View full text Add to dashboard Cite

Noncoding RNAs (ncRNAs) are active regulators of a wide range of biological and physiological processes, including the majority of mammalian reproductive events. Knowledge of the biological activities of ncRNAs in the context of mammalian reproduction will allow for a more comprehensive and comparative understanding of male sterility and fertility. In this review, we describe recent advances in ncRNA‐mediated control of mammalian reproduction and emphasize the importance of ncRNAs in several aspects of mammalian reproduction, such as germ cell biogenesis and reproductive organ activity. Furthermore, we focus on gene expression regulatory feedback loops including hormones and ncRNA expression to better understand germ cell commitment and reproductive organ function. Finally, this study shows the role of ncRNAs in male reproductive failure and provides suggestions for further research.

show abstract

“…Heat and cold stress, hormone levels and endocrine disruptors, dietary structure, exercise, growth and development, and congenital factors all have effects on the function of testis ( Belloc et al, 2014 ; Tian et al, 2019 ; Qin et al, 2021 ). According to the World Health Organization (WHO), 15% of couples worldwide struggle with infertility, of which, 50% of cases of infertility are due to men having troubles such as varicoceles and azoospermia ( Jensen et al, 2017 ; Wu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Gut microbiota supports male reproduction via nutrition, immunity, and signaling

et al. 2022

View full text Add to dashboard Cite

Gut microbiota (GM) is a major component of the gastrointestinal tract. Growing evidence suggests that it has various effects on many distal organs including the male reproductive system in mammals. GM and testis form the gut-testis axis involving the production of key molecules through microbial metabolism or de novo synthesis. These molecules have nutrition, immunity, and hormone-related functions and promote the male reproductive system via the circulatory system. GM helps maintain the integral structure of testes and regulates testicular immunity to protect the spermatogenic environment. Factors damaging GM negatively impact male reproductive function, however, the related mechanism is unknown. Also, the correlation between GM and testis remains to be yet investigated. This review discusses the complex influence of GM on the male reproductive system highlighting the impact on male fertility.

show abstract

Male Infertility in Humans: An Update on Non-obstructive Azoospermia (NOA) and Obstructive Azoospermia (OA)

Cited by 17 publications

References 86 publications

Clinical outcome of microsurgical vasoepididymostomy versus epididymal or testicular sperm retrieval combined with intracytoplasmic sperm injection in obstructive azoospermia males

Clinical outcome of microsurgical vasoepididymostomy versus epididymal or testicular sperm retrieval combined with intracytoplasmic sperm injection in obstructive azoospermia males

Functions and mechanism of noncoding RNA in regulation and differentiation of male mammalian reproduction

Gut microbiota supports male reproduction via nutrition, immunity, and signaling

Contact Info

Product

Resources

About