Male Infertility and Somatic Health

Murshidi, Mujalli Mhailan; Choy, Jeremy T.

doi:10.1016/j.ucl.2019.12.008

Cited by 25 publications

(16 citation statements)

References 55 publications

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“…Many factors may affect the consequences caused by open or punch biopsy. Except the type of biopsy there are several factors that may affect the final outcome such as the size of needle, age, localization, direction and number of biopsies [27][28][29][30].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

Šušnjar

Prusac

Švagelj³

et al. 2021

Animals

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Background: The aim of this study was to compare consequences in single and triple testicular biopsy by biopty gun in pubertal rats using histological and immunohistochemical analysis. Methods: Thirty-two Sprague-Dawley male rats were used as the experimental model. The rats were randomly divided into three study groups. The rats from the first group (n = 12) received a single-biopsy of upper pole of the left testis, while the rats from the second group (n = 10) received triple-biopsy of upper and lower poles and lateral surface of left testis. The third group (n = 10) was a control group. On the eightieth day after the biopsy in all rats bilateral orchiectomy and funiculectomy were performed to obtain testicular tissue and sperm for analysis. The consequences of the puncture were observed by pathohistology, immunohistochemistry and semen analysis. Results: The results of the study showed lower percentage of sperm count (14.5 mill/mL vs. 16 mill/mL, p = 0.130), sperm motility (24.6% vs. 32.7%, p > 0.05), abnormal sperm (30% vs. 27%, p > 0.05), atrophic tubules (21% vs. 6%, p < 0.001), volume (1.7 mL vs. 2.28 mL, p < 0.01) and apoptotic index (1.56 vs. 1.19, p = 0.650) in the testes with a triple-biopsy compared to the testes with a single-biopsy. Semen analysis showed a borderline significant difference between the group with triple-biopsy where sperm count was lower than it in the control group (14.5 mill/mL vs. 17.5 mill/mL, p = 0.05). A single-biopsy has little effect on the testis, especially on overall fertility. A triple-biopsy showed higher degree of the testicular damage but without a significant impact on overall fertility. Semen analysis showed that single- and triple-biopsies did not have a significant effect on sperm count, motility and morphology. Conclusion: Biopty gun procedure is a cheap, simple and reliable method for testicular biopsy in rats without a significant effect on sperm count, motility and morphology.

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Section: Discussionmentioning

confidence: 99%

The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

Šušnjar

Prusac

Švagelj³

et al. 2021

Animals

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“…It is also important to understand and to predict the risk of other diseases in patients with male infertility and decide appropriate treatment modalities ( 16 ). Recently, several studies have focused on understanding the high-risk disease conditions associated with male infertility ( 18 , 19 ). In some cases, the manifestation of infertility indicated the risk of a future health concern ( 20 ).…”

Section: Introductionmentioning

confidence: 99%

“…In some cases, the manifestation of infertility indicated the risk of a future health concern ( 20 ). Males suffering from infertility have been known to have a higher risk of testicular cancer ( 21 , 22 ), prostate cancer ( 21 ), cardiovascular diseases ( 23 , 24 ) and metabolic syndrome ( 19 , 25 , 26 ).…”

Section: Introductionmentioning

confidence: 99%

OUP accepted manuscript

Joseph

Mahale

2021

Database

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Male infertility is a multifactorial condition that contributes to around one-third of cases of infertility worldwide. Several chromosomal aberrations, single-gene and polygenic associations with male factor defects have been reported. These defects manifest as sperm number or sperm quality defects leading to infertility. However, in almost 40% of cases, the genetic etiology of male infertility remains unexplained. Understanding the causal genetic factors is crucial for effective patient management and counseling. Integrating the vast amount of available omics data on male infertility is a first step towards understanding, delineating and prioritizing genes associated with the different male reproductive disorders. The Male Infertility Knowledgebase (MIK) is a manually curated repository developed to boost research on the elusive genetic etiology of male infertility. It integrates information on ∼17 000 genes, their associated pathways, gene ontology, diseases and gene and sequence-based analysis tools. In addition, it also incorporates information on reported chromosomal aberrations and syndromic associations with male infertility. Disease enrichment of genes in MIK indicate a shared genetic etiology between cancer, male and female infertility disorders. While the genes involved in cancer pathways were found to be common causal factors for sperm number and sperm quality defects, the interleukin pathways were found to be shared and enriched between male factor defects and non-reproductive conditions like cardiovascular diseases, metabolic diseases, etc. Disease information in MIK can be explored further to identify high-risk conditions associated with male infertility and delineate shared genetic etiology. Utility of the knowledgebase in predicting novel genes is illustrated by identification of 149 novel candidates for cryptorchidism using gene prioritization and network analysis. MIK will serve as a platform for review of genetic information on male infertility, identification pleiotropic genes, prediction of novel candidate genes for the different male infertility diseases and for portending future high-risk diseases associated with male infertility. Database URL : http://mik.bicnirrh.res.in/

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“…Conversely, BMI, FSH, LH, and other hormones such as PRL, TSH, fT3, fT4 or Vitamin D did not predict the presence of comorbidities, as scored for CCI [?]1. Indeed, to score patients' somatic general health 7 , we used CCI, the most widely used scoring system to assess the rate and burden of comorbidities and predict mortality. While causal inferences cannot be drawn, strength of our study on a relatively-large homogenous same-ethnicity cohort of women, was the novel finding that AMH might be a marker of general female health, as observed for sperm concentration in males 10 .…”

Section: Discussionmentioning

confidence: 99%

“…In males, there are specific reproductive parameters that have been found to be associated with a decreased general health status as expressed by comorbidity scores 7 -indices that provide general health assessment and predict mortality by applying weights or severity ratings for each comorbid condition 8 . More specifically, low sperm concentration, low testosterone and high follicle-stimulating hormone (FSH) values in primary infertile men have been found to be inversely associated with the comorbidity burden expressed by the Charlson Comorbidity Index (CCI) 9,10 .…”

Section: Introductionmentioning

confidence: 99%

Anti-Müllerian Hormone Levels as a Predictor of Female General Health Status: A Cross-Sectional Study

Quartucci¹,

Papaleo²,

Privitera³

et al.

Authorea

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Objective: To assess the correlations between clinical and hormonal parameters and comorbidity burden in Caucasian women presenting for fertility treatment. Design: Cross-sectional study. Setting: Single academic reproductive medicine center. Patient: Cohort of 3163 single-ethnicity women seeking medical help for fertility treatment, who underwent centralized lab testing for fertility-related hormonal assessment. Intervention: Complete clinical and laboratory data from the entire cohort of patients were retrospectively analysed. Main outcome measures: Assessment of i) the comorbidity burden scored via the Charlson Comorbidity Index (CCI; categorized as 0 vs. 1 vs. >2); and, ii) the potential associations between CCI and clinical and hormonal parameters. Results: Descriptive statistics and regression models tested the associations between clinical and laboratory parameters and CCI. Of 3163, CCI=0, CCI=1 and CCI>2 were found in 2977 (94.1%), 113 (3.6%) and 73 (2.3%) patients, respectively. Age, gravidity, Anti-Müllerian hormone (AMH) and thyroid stimulating hormone (TSH) values were found to be significantly different among CCI groups (all p[?] 0.01). At regression models, age at presentation and AMH emerged as independent predictors of CCI>1. Age at presentation <36 years (OR=1.742, 95% CI [1.284; 2.364]) and an AMH level <2.3 ng/ml (OR=1.864, 95% CI [1.29; 2.69]) were the most informative cutoff values for CCI >1. Conclusions: A younger age at presentation and lower AMH levels are significant predictors of decreased general health in women requiring clinical evaluation for fertility treatment. As observed for sperm parameters in men, AMH might serve as a proxy of women's general health status.

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Male Infertility and Somatic Health

Cited by 25 publications

References 55 publications

The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

The Effect of Single and Triple Testicular Biopsy Using Biopty Gun on Spermatogenesis in Pubertal Rats

OUP accepted manuscript

Anti-Müllerian Hormone Levels as a Predictor of Female General Health Status: A Cross-Sectional Study

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