Male Gonadal Function After Pediatric Hematopoietic Stem Cell Transplantation: A Systematic Review

Mathiesen, Sidsel; Andrés‐Jensen, Liv; Nielsen, Malene Mejdahl; Sørensen, Kaspar; Ifversen, Marianne; Jahnukainen, Kirsi; Juul, Anders; Müller, Klaus

doi:10.1016/j.jtct.2022.05.036

Cited by 5 publications

(7 citation statements)

References 70 publications

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“…Of the HSCT recipients, 11.0% received hormone induction. This finding is well in line with a prior review on pediatric HSCT recipients, where 11.8% of the patients underwent hormone therapy to induce puberty (calculated from Table 2, 55 out of 466 participants) 20 . However, even higher prevalence rates have been reported after pediatric allogeneic HSCT, with mainly TBI‐based conditioning regimens, where hormone induction therapy was received by as many as 21.1% of the patients 21 .…”

Section: Discussionsupporting

confidence: 86%

“…20,21 In the former study, HSCT recipients who had a TBI based conditioning therapy had a 35.5% prevalence of TRT and those with a non-TBI based conditioning 18.8% (calculated from Table 2). 20 These results are consistent with the recent International Guideline Harmonization Group recommendation that men who have undergone HSCT with TBI based conditioning or received ≥12 Gy of radiotherapy potentially exposing the testes should receive surveillance of testosterone concentrations at clinically appropriate intervals. 6 In line with previous findings on the relationship between TRT and endocrine/cardiovascular risk factors, 10,12 survivors with TRT in the present study had 7-8 times higher prevalence of other hormonal deficiencies (prior growth hormone, ongoing thyroid medication) compared to survivors without ongoing TRT.…”

Section: Discussionmentioning

confidence: 97%

“…This finding is well in line with a prior review on pediatric HSCT recipients, where 11.8% of the patients underwent hormone therapy to induce puberty (calculated from Table 2, 55 out of 466 participants). 20 However, even higher prevalence rates have been reported after pediatric allogeneic HSCT, with mainly TBI-based conditioning regimens, where hormone induction therapy was received by as many as 21.1% of the patients. 21 In the present national sample, for the majority of patients who underwent hormone-induced puberty, testosterone was combined with growth hormone therapy.…”

Section: Discussionmentioning

confidence: 99%

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Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors: A population‐based study (the Fex‐Can study)

Haavisto,

Lampic,

Wettergren

et al. 2024

Intl Journal of Cancer

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Childhood cancer survivors are at risk of various endocrine late effects affecting their quality of life. The aim of this study was to assess the prevalence and predictors of endocrine and reproductive outcomes in young adult survivors. A secondary aim was to assess possible associations between testosterone replacement therapy (TRT) and other endocrine, cardiovascular and psychosocial late effects. This nationwide study comprised 1212 male childhood cancer survivors aged 19–40 years, identified through the National Quality Registry for Childhood Cancer in Sweden. Median age at diagnosis during 1981–2017 was 7 (range 0–17) and at study 29 (19–40) years. The study combined self‐report survey data with cancer treatment data from the national registry. Hormone‐induced puberty was self‐reported by 3.8% of the survivors and ongoing TRT by 6.0%. In separate logistic regression analyses, these treatments were associated with hematopoietic stem cell transplantation and cranial radiotherapy. Hormone‐induced puberty was additionally associated with younger age at diagnosis. Men with TRT had a higher prevalence of other endocrine deficiencies, cholesterol medication, depressive symptoms and fatigue as well as a lower probability of living with a partner, having a biological child or current occupation. In the total male cohort, 28.2% reported having a biological child. Reassuring reproductive outcomes after less intensive therapies and low frequency of TRT were observed in young adult male childhood cancer survivors treated in the most recent treatment era. However, men with TRT suffered from several other endocrine, cardiovascular and psychosocial late effects, indicating a need for long‐term monitoring of this high‐risk group.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

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Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors: A population‐based study (the Fex‐Can study)

Haavisto,

Lampic,

Wettergren

et al. 2024

Intl Journal of Cancer

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“…Stem cell transplantation is a very promising therapeutic modality in the field of neuroprosthetics 30–32 . However, previous stem cell transplantation methods, in which the stem cells themselves were directly transplanted into animals, would create a problem, which is the differentiation of stem cells.…”

Section: Discussionmentioning

confidence: 99%

“…Although an association between these two nuclei and consciousness has been reported, 14,29 Stem cell transplantation is a very promising therapeutic modality in the field of neuroprosthetics. [30][31][32] However, previous stem cell transplantation methods, in which the stem cells themselves were directly transplanted into animals, would create a problem, which is the differentiation of stem cells. When cultured in vitro, the survival environment of stem cells is homogenous, controllable, and adjustable, which can ensure their normal differentiation; however, after transplantation into the body, the cellular microenvironment changes all the time, and the in vivo environment is more complex and unstable, which impacts the differentiation direction and efficiency of stem cells, and the uncertainty of differentiation direction increases greatly.…”

Section: Transplanted Glutamatergic Neuronal Precursor Cells Promote ...mentioning

confidence: 99%

Transplantation of glutamatergic neuronal precursor cells in the paraventricular thalamus and claustrum facilitates awakening with recovery of consciousness

Zhao

Wei

et al. 2023

CNS Neurosci Ther

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Background: Stem cells offer a promising therapeutic strategy for patients with disorders of consciousness (DOC) after severe traumatic brain injury (TBI), but the optimal transplantation sites and cells are not clear. Although the paraventricular thalamus (PVT) and claustrum (CLA) are associated with consciousness and are candidate transplantation targets, few studies have been designed to investigate this possibility. Methods: Controlled cortical injury (CCI) was performed to establish a mouse model of DOC. CCI-DOC paradigm was established to investigate the role of excitatory neurons of PVT and CLA in disorders of consciousness. The role of excitatory neuron transplantation in promoting arousal and recovery of consciousness was determined by optogenetics, chemogenetics, electrophysiology, Western blot, RT-PCR, double immunofluorescence labeling, and neurobehavioral experiments.Results: After CCI-DOC, neuronal apoptosis was found to be concentrated in the PVT and CLA. Prolonged awaking latency and cognitive decline were also seen after destruction of the PVT and CLA, suggesting that the PVT and CLA may be key nuclei in DOC. Awaking latency and cognitive performance could be altered by inhibiting or activating excitatory neurons, implying that excitatory neurons may play an important role in DOC. Furthermore, we found that the PVT and CLA function differently, with the PVT mainly involved in arousal maintenance while the CLA plays a role mainly in the generation of conscious content. Finally, we found that by transplanting excitatory neuron precursor cells in the PVT and CLA, respectively, we could facilitate

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Endocrine Disorders, Fertility, and Sexual Health

Salooja,

Rovó,

Dalle

2024

The EBMT Handbook

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Male Gonadal Function After Pediatric Hematopoietic Stem Cell Transplantation: A Systematic Review

Cited by 5 publications

References 70 publications

Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors: A population‐based study (the Fex‐Can study)

Reproductive late effects and testosterone replacement therapy in male childhood cancer survivors: A population‐based study (the Fex‐Can study)

Transplantation of glutamatergic neuronal precursor cells in the paraventricular thalamus and claustrum facilitates awakening with recovery of consciousness

Endocrine Disorders, Fertility, and Sexual Health

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