Male Genitourinary Abnormalities and Maternal Diethylstilbestrol

Cosgrove, Malcolm D.; Benton, Barbara; Henderson, Brian E.

doi:10.1016/s0022-5347(17)58407-4

Cited by 85 publications

(28 citation statements)

References 10 publications

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“…Animal experiments have shown that nonsteroidal oestrogen treatment of pregnant mice can lead to undescended and hypogenetic testes (Nomura & Kanzak, 1977). Similar abnormalities have been reported in male offspring of women exposed to diethylstilboestrol (Cosgrove et al, 1977) and to oral contraceptives (Rothman and Louik, 1978) during pregnancy. Significantly, hypogenetic testes are also at high risk of cancer (Haines & Grabstaldt, 1950).…”

Section: Testicular Cancersupporting

confidence: 80%

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Ross¹,

McCurtis²,

Be³

et al. 1979

Br J Cancer

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Summary.-Data from the Los Angeles County Cancer Surveillance Program (CSP) from 1972 to 1975 were used to study the descriptive epidemiology of testicular cancer and prostatic cancer. The very high black/white ratio and late age peak of cancer of the prostate contrasted sharply with the very low ratio and early age peak of testicular cancer. However, both sites had higher rates among upper occupational and social class groupings. Available descriptive and analytical research suggests that the etiology of prostatic cancer is most probably related to hormonal influences rather than to a horizontally transmitted agent, while the etiology of testicular cancer is most probably related to endogenous or exogenous hormonal influences in utero or in infancy, or to in utero exposure to other exogenous agents.

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Section: Testicular Cancersupporting

confidence: 80%

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Ross¹,

McCurtis²,

Be³

et al. 1979

Br J Cancer

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show abstract

“…Exposure to the pharmaceutical diethylstilbestrol (DES) was excluded in this study. Cosgrove et al (47) reported one case of hypospadias among 11 DES-exposed males compared with none in 4 controls. This is hardly evidence for a causal relationship.…”

Section: Etiologymentioning

confidence: 99%

Hypospadias and endocrine disruption: is there a connection?

Baskin

Himes

Colborn

2001

Environ Health Perspect

248

131

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Hypospadias is one of the most common congenital anomalies in the United States, occurring in approximately 1 in 250 newborns or roughly 1 in 125 live male births. It is the result of arrested development of the urethra, foreskin, and ventral surface of the penis where the urethral opening may be anywhere along the shaft, within the scrotum, or in the perineum. The only treatment is surgery. Thus, prevention is imperative. To accomplish this, it is necessary to determine the etiology of hypospadias, the majority of which have been classified as idiopathic. In this paper we briefly describe the normal development of the male external genitalia and review the prevalence, etiology, risk factors, and epidemiology of hypospadias. The majority of hypospadias are believed to have a multifactorial etiology, although a small percentage do result from single gene mutations. Recent findings suggest that some hypospadias could be the result of disrupted gene expression. Discoveries about the antiandrogenic mechanisms of action of some contemporary-use chemicals have provided new knowledge about the organization and development of the urogenital system and may provide additional insight into the etiology of hypospadias and direction for prevention.

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“…An increased risk has also been reported for the contralateral descendent testis (Henderson et al 1979), suggesting common risk factors. Some prenatal risk factors seem to be common for both cryptorchidism and testicular cancer, such as high levels of estrogen in the first trimester (Bernstein et al 1988;Cosgrove et al 1977).…”

mentioning

confidence: 99%

Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.

Hardell

Bavel

Lindström

et al. 2003

Environ Health Perspect

195

163

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An increasing incidence of testicular cancer has been reported from several countries in the Western world during the last decades. According to current hypothesis, testicular cancer is initiated during the fetal period, and exposure to endocrine disruptors, i.e., xenoestrogens, has been of concern. In this investigation we studied the concentrations of the sum of 38 polychlorinated biphenyls (PCBs), p,p´-dichlorodiphenyl-dichloroethylene, hexachlorobenzene (HCB), and chlordanes, in 61 cases with testicular cancer and 58 age-matched controls. Furthermore, case and control mothers were also asked to participate, and 44 case mothers and 45 control mothers agreed. They were of similar age. In cases only the concentration on lipid basis of cis-nonachlordane was significantly increased, whereas case mothers showed significantly increased concentrations of the sum of PCBs, HCB, trans-and cis-nonachlordane, and the sum of chlordanes. Among case mothers the sum of PCBs yielded an odds ratio (OR) of 3.8; 95% confidence interval (CI), 1.4-10 was calculated using the median concentration for the control mothers as cutoff value. For HCB, OR = 4.4 (95% CI, 1.7-12); for trans-nonachlordane, OR = 4.1 (95% CI, 1.5-11); for cis-nonachlordane, OR = 3.1 (95% CI, 1.2-7.8); and for sum of chlordanes, OR = 1.9 (95% CI, 0.7-5.0). No consistent different risk pattern was found for seminoma or nonseminoma testicular cancer.

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Male Genitourinary Abnormalities and Maternal Diethylstilbestrol

Cited by 85 publications

References 10 publications

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Descriptive epidemiology of testicular and prostatic cancer in Los Angeles

Hypospadias and endocrine disruption: is there a connection?

Increased concentrations of polychlorinated biphenyls, hexachlorobenzene, and chlordanes in mothers of men with testicular cancer.

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