Male genital edema in Crohn’s disease

Genital lichen sclerosus and melanoma; a systematic review

“…MGLSc may be much more frequent than is generally supposed in early childhood (being diagnosed histologically in 14%–95% of prepuces removed for phimosis). 2 , 3 …”

“…An association with vulval (Vu) and penile (Pe) squamous cell carcinoma (SCC) is now well established. [1][2][3] Reports of an association with genital (G) melanoma (MM) have appeared in the literature. We have previously published three cases of penile (Pe) MM complicating male (M) GLSc and recently encountered another case in our multidisciplinary practice.…”

BritishAssociation ofDermatologists' guidelines for the management of squamous cell carcinomain situ(Bowen's disease) 2014

“…Circumcision removes a major risk factor for cancer and provides more extensive tissue for histology. 149 5-FU as a 5% cream is a well-established conventional option for the treatment of BDP, EQ and BP, 147,149,157 but there have not been any clinical trials. Treatment options for EQ include the use of topical 5-FU, imiquimod or PDT, although much of the evidence of efficacy depends on case reports.…”

Penile lymphoedema: approach to investigation and management

“…Metastatic CD presenting as penoscrotal oedema is an unusual but important presentation to be included in the list of cutaneous manifestations of CD. [19][20][21] The majority of cases present after the onset of bowel symptoms; however, in a distinct minority, the skin symptoms precede gastrointestinal symptoms by months to years, 22 as seen in the four patients in our series. When penile lymphoedema precedes CD, the latter may be occult and asymptomatic.…”

“…Metastatic CD describes the presence of noncaseating granuloma of the skin at sites separated from the gastrointestinal tract by normal tissue. Metastatic CD presenting as penoscrotal oedema is an unusual but important presentation to be included in the list of cutaneous manifestations of CD . The majority of cases present after the onset of bowel symptoms; however, in a distinct minority, the skin symptoms precede gastrointestinal symptoms by months to years, as seen in the four patients in our series.…”