Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes

Mazzilli, Rossella; Rucci, C; Vaiarelli, Alberto; Cimadomo, Danilo; Ubaldi, Filippo Maria; Ferlin, Alberto

doi:10.1007/s40618-022-02000-4

Cited by 12 publications

(6 citation statements)

References 56 publications

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“…The importance of understanding the mechanisms underlying PME is not only of academic interest, as the use of medically assisted reproduction (MAR) treatments is constantly increasing, leading to diversion of research efforts from molecular studies to improvement of MAR technologies. Consequently, much less attention has been given to possible negative impacts of some of these treatments, which inevitably involve PM leakage, on embryo development, implantation, and clinical and obstetric outcomes [100][101][102] . Furthermore, the novel reproductive technologies known as mitochondrial donation or mitochondrial replacement therapy (MRT), raise challenging ethical and safety issues, as only a few successful MRT case reports are available.…”

Section: Discussionmentioning

confidence: 99%

Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization

Ben-Hur,

Afar,

Politi

et al. 2023

Preprint

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Mitochondria are maternally inherited, but the mechanisms underlying paternal mitochondrial elimination (PME) after fertilization are far less clear. UsingDrosophila, we show that special egg-derived multivesicular bodies (MVBs) promote PME by activating LC3-associated phagocytosis (LAP), a cellular defense pathway commonly employed against invading microbes. Upon fertilization, the egg MVBs engage and densely coat the sperm flagellum, forming extended flagellum vesicular sheaths (FVSs), within which the paternal mitochondria degrade. Inactivation of multiple LAP pathway components, such as Rubicon, a LAP-specific class III PI(3)K complex protein, significantly attenuates PME. Furthermore, recruitment of Atg8/LC3 to the FVS requires both Rubicon and the Atg8/LC3 conjugation machinery. Other LAP pathway events, such as production of the phospholipid PtdIns(3)P and reactive oxygen species (ROS), also unfold during PME. Finally, we provide evidence that a similar pathway might also mediate PME in mammals, highlighting the notion that eggs may regard paternal mitochondria as potentially dangerous trespassers.

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Section: Discussionmentioning

confidence: 99%

Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization

Ben-Hur,

Afar,

Politi

et al. 2023

Preprint

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“…The experience gathered from various micromanipulation methods of gametes, including zona-opening procedures, subzonal sperm insertion, and sperm microinjection into the ooplasm, have demonstrated not only their clinical utility in assisted fertilization but also suggests the potential for selective application of these techniques and their combinations in the treatment of male infertility. The possible interference of gamete micromanipulation during ICSI with genomic imprinting and pre-zygotic sperm selection as potential teratogens could be important factors to consider [139]. ICSI produces chromosomal abnormalities, observed not only in infertile men and their spermatozoa but also in pre-implantation embryos resulting from microinjection [140].…”

Section: Genetic and Epigenetic Considerations: Risk Of Transmission ...mentioning

confidence: 99%

Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation

Aponte,

Gutierrez-Reinoso,

Garcia-Herreros

2023

Life

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This review aims to explore advanced reproductive technologies for male fertility preservation, underscoring the essential role that animal models have played in shaping these techniques through historical contexts and into modern applications. Rising infertility concerns have become more prevalent in human populations recently. The surge in male fertility issues has prompted advanced reproductive technologies, with animal models playing a pivotal role in their evolution. Historically, animal models have aided our understanding in the field, from early reproductive basic research to developing techniques like artificial insemination, multiple ovulation, and in vitro fertilization. The contemporary landscape of male fertility preservation encompasses techniques such as sperm cryopreservation, testicular sperm extraction, and intracytoplasmic sperm injection, among others. The relevance of animal models will undoubtedly bridge the gap between traditional methods and revolutionary next-generation reproductive techniques, fortifying our collective efforts in enhancing male fertility preservation strategies. While we possess extensive knowledge about spermatogenesis and its regulation, largely thanks to insights from animal models that paved the way for human infertility treatments, a pressing need remains to further understand specific infertility issues unique to humans. The primary aim of this review is to provide a comprehensive analysis of how animal models have influenced the development and refinement of advanced reproductive technologies for male fertility preservation, and to assess their future potential in bridging the gap between current practices and cutting-edge fertility techniques, particularly in addressing unique human male factor infertility.

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“…Couple infertility ranges between 12.6 and 17.5% [123], out of which half of the cases are attributed to the male factor due to low sperm concentration or poor spermatozoa quality [124]. Among the major causes of male infertility are genetic causes, like chromosomal aberrations and microdeletions of the Y chromosome.…”

Section: Genetic Causes Of Spermatogenesis Disturbances 41 Microdelet...mentioning

confidence: 99%

Environmental and Genetic Traffic in the Journey from Sperm to Offspring

Sengupta,

Dutta,

Liew

et al. 2023

Biomolecules

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Recent advancements in the understanding of how sperm develop into offspring have shown complex interactions between environmental influences and genetic factors. The past decade, marked by a research surge, has not only highlighted the profound impact of paternal contributions on fertility and reproductive outcomes but also revolutionized our comprehension by unveiling how parental factors sculpt traits in successive generations through mechanisms that extend beyond traditional inheritance patterns. Studies have shown that offspring are more susceptible to environmental factors, especially during critical phases of growth. While these factors are broadly detrimental to health, their effects are especially acute during these periods. Moving beyond the immutable nature of the genome, the epigenetic profile of cells emerges as a dynamic architecture. This flexibility renders it susceptible to environmental disruptions. The primary objective of this review is to shed light on the diverse processes through which environmental agents affect male reproductive capacity. Additionally, it explores the consequences of paternal environmental interactions, demonstrating how interactions can reverberate in the offspring. It encompasses direct genetic changes as well as a broad spectrum of epigenetic adaptations. By consolidating current empirically supported research, it offers an exhaustive perspective on the interwoven trajectories of the environment, genetics, and epigenetics in the elaborate transition from sperm to offspring.

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Male factor infertility and assisted reproductive technologies: indications, minimum access criteria and outcomes

Cited by 12 publications

References 56 publications

Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization

Egg MVBs elicit an antimicrobial pathway to degrade paternal mitochondria after fertilization

Bridging the Gap: Animal Models in Next-Generation Reproductive Technologies for Male Fertility Preservation

Environmental and Genetic Traffic in the Journey from Sperm to Offspring

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