Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: A voxel-based morphometry

Taki, Yasuyuki; Kinomura, Shigeo; Awata, Shuichi; Inoue, Kentaro; Sato, Kazunori; Ito, Hiroshi; Goto, Ryoi; Uchida, Shinya; Tsuji, Ichiro; Arai, Hiroyuki; Kawashima, Ryuta; Fukuda, Hiroshi

doi:10.1016/j.jad.2005.08.003

Cited by 114 publications

(83 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Voxel-based morphometry (VBM) is a fully automated imaging analysis technique, thus provides objective information regarding brain tissue concentration or regional volume changes of gray matter, white matter, and cerebrospinal fluid (CSF) respectively with minimal operational bias (9). VBM has been proved useful to reveal brain abnormalities in various neuropsychiatric diseases such as schizophrenia (10), major depressive disorder (8,(11)(12)(13), and obsessive compulsive disorder (14).…”

Section: Introductionmentioning

confidence: 99%

“…Several VBM studies in patients with MDD have reported differences in gray matter volume (GMV) and concentration (GMC) compared to healthy controls with contradictory results (11)(12)(13), which could be partly explained by heterogeneity of patient groups. Structural changes the brain in patients with MDD could be affected by diverse factors such as age of onset, sex, previous number of depressive episodes, duration of illness, and antidepressant medication.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry

Tae

2015

Investig Magn Reson Imaging

View full text Add to dashboard Cite

Background and Purpose:The association between the low emotional regulation and the brain structural change of major depressive disorder (MDD) has been proposed, but the voxel-based morphometry (VBM) studies on female MDD are rare. The purpose of the present study was to show the regional volume changes of gray matter (GM) in female patients with MDD by optimized VBM. Methods: To control subjects homogeneity, twenty female MDD patients and age, sex matched 21 normal controls were included for the VBM analysis. To identify the change of regional gray matter volume (GMV), the optimized VBM was performed with T1 MRIs. The amounts of gray/white matter and intracranial cavity volumes (ICV) were measured. The analysis of covariance (ANCOVA) and partial correlation analyses covariate with age and ICV were applied for VBM. Results: The age and ICV distributions were similar between the two groups. In the ANCOVA, the total GMV of MDD was smaller than that of normal controls. In the VBM, regional GMV was relatively decreased in the limbic system (amygdalae, ambient gyri, hippocampi heads, subiculum, posterior parahippocampal gyri, pulvinar nuclei, dorsal posterior cingulate gyri, and left pregenual cingulate gyrus). The lingual gyri, short insular gyri, right fusiform gyrus, and right inferior frontal gyrus were also showed decreased regional GMV. Conclusion:The results of this study indicate that the female MDD is mainly associated with the structural deficits of the limbic system and limbic system related cortices, which were known to the center of emotions.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry

Tae

2015

Investig Magn Reson Imaging

View full text Add to dashboard Cite

show abstract

“…10 Voxel-based morphometry (VBM) is extremely useful because brain regions whose boundaries are difficult to define can be analyzed. VBM has detected smaller volumes of the medial frontal lobes in patients with subthreshold depression, 11 as well as of the right hippocampus and the middle frontal gyrus in patients with major depression. 12 Neuroimaging genetics offer a good possibility to combine the morphological and neurochemical aspects, for example, structural and serotonergic alterations.…”

Section: Introductionmentioning

confidence: 99%

Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression

et al. 2008

View full text Add to dashboard Cite

The serotonergic system is involved in the pathophysiology of major depression as well as in the early central nervous system development and adult neuroplasticity. The aim of the study was to examine in 77 patients with major depression and 77 healthy controls the association between the triallelic polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and gray matter (GM) brain volumes measured with 1.5 T magnetic resonance imaging. Voxel-based morphometry were estimated on magnetic resonance images and genotyping was performed. We found that healthy controls have a strong association between the 5-HTTLPR and GM volumes of the dorsolateral prefrontal cortex, left anterior gyrus cinguli, left amygdala as well as right hippocampus, whereas there is no such association in patients with major depression. Healthy subjects carrying the S-or L G -allele have smaller GM volumes than those with the L A -allele, indicating that 5-HTTLPR contributes to the development of brain structures. Patients with depression show reduced GM volumes, particularly when they are homozygous for the L A -allele, suggesting that these patients are more vulnerable for morphological changes during depressive episodes.

show abstract

“…Vários estudos indicam atrofia cerebral generalizada e localizada, como atrofia do córtex pré-frontal, giro do cíngulo, núcleo caudado, cerebelo e hipocampo (Schweitzer et al, 2001;Taki et al, 2005). Em geral essa atrofia está relacionada a déficits cognitivos, resposta pobre ao tratamento, e aumento da recorrência da doença.…”

Section: Introductionunclassified

“…Desde 1993, o hipocampo tem sido estudado em exames de ressonância magnética (RM). Alguns estudos de volumetria encontraram atrofia significativa dessa região O'Brien et al, 2004;Janssen et al, 2007), enquanto outros não (Posener et al, 2003;Sheline, 2003;Taki et al, 2005).…”

Section: Introductionunclassified

Correlação entre memória e volume de estruturas cerebrais em idosos deprimidos: um estudo de morfometria baseada no voxel

Ávila¹

View full text Add to dashboard Cite

Ao Prof. Dr. Cássio Machado de Campos Bottino, que sempre me orientou com serenidade, buscando respostas para muitas de minhas questões, e cujas contribuições foram fundamentais para a realização deste trabalho.Ao Prof. Dr. Geraldo Busatto, pelas valiosas sugestões.A Duncan Thomas, por seu amor e incentivo. E, por fim, aos pacientes e seus familiares, pela participação voluntária neste estudo.

show abstract

Male elderly subthreshold depression patients have smaller volume of medial part of prefrontal cortex and precentral gyrus compared with age-matched normal subjects: A voxel-based morphometry

Cited by 114 publications

References 28 publications

Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry

Regional Gray Matter Volume Reduction Associated with Major Depressive Disorder: A Voxel-Based Morphometry

Reduced gray matter brain volumes are associated with variants of the serotonin transporter gene in major depression

Correlação entre memória e volume de estruturas cerebrais em idosos deprimidos: um estudo de morfometria baseada no voxel

Contact Info

Product

Resources

About