Male contraception

Amory, John K.

doi:10.1016/j.fertnstert.2016.08.036

Cited by 59 publications

(52 citation statements)

References 84 publications

(69 reference statements)

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“…Some family planning institutions are oriented towards contraceptive use in women rather than in men, but the results of contraceptive method surveys in various countries show that 50% of couples use condoms and vasectomies as contraceptives (Anderson & Baird 2002). Some women cannot use contraception due to their health condition, so many men take over to use contraception to prevent unintended pregnancies (Amory 2016).…”

Section: Introductionmentioning

confidence: 99%

Determinants Factors of Vasectomy Method Selection

Yunitasari¹,

Pradanie²,

Hardiansyah³

2017

J. Ners

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Introduction:The level of male participation in family planning by choosing vasectomy in East Lampung region Pekalongan health centres is still low, although the success rate of vasectomy as a family planning method is very high. This study aims to explain the factors related to men's choice of vasectomy in the Pekalongan health center East Lampung. Methods: This study used an analytical study design with a cross-sectional approach. Samples were 117 men of reproductive age gathered using purposive sampling. The independent variables were knowledge, attitudes, parity, age, availability of health resources and infrastructure, health education, attitude and behaviour of health care workers and family support. The dependent variable was the men's participation in vasectomy as a family planning method. Data were retrieved using questionnaires and statistically analysed using the Chi-Square test. Results: Factors affecting the selection of vasectomy as a family planning method amongst men of reproductive age were attitude (p=0.020), parity (p=0.022), age (p=0.021), the availability of health resources and health infrastructure (p=0.018), and family support (p=0.011). However, the knowledge, health education, and the attitudes and behaviour of health workers did not affect the selection of vasectomy as a family planning method. Conclusiom: Public health centres are expected to build family planning services, especially for vasectomies, through, for example, the provision of vasectomy facilities which can reach the community and the establishment of cadres for male birth control.

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Section: Introductionmentioning

confidence: 99%

Determinants Factors of Vasectomy Method Selection

Yunitasari¹,

Pradanie²,

Hardiansyah³

2017

J. Ners

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“…6 Nevertheless, the difference between races can complicate interpretation of MHC trials performed in different parts of the world. 2 The need to inject testosterone analogues poses another hurdle. Indeed, John Amory, professor of medicine at the University of Washington, believes that new methods of reversible male contraception will become available "in the not too distant future".…”

Section: Splmentioning

confidence: 99%

“…However, in one study, 12% of men receiving weekly intramuscular injections discontinued because of the injection schedule. 2 Moreover, combination regimens (see below) might mean administrating androgens and progestins through different routes and at different times. 1 So, an oral or transdermal formulation might be needed to persuade some men to use MHC.…”

Section: Splmentioning

confidence: 99%

“…However, some men experienced mild side-effects, including acne, weight gain and a reversible decrease in HDL-cholesterol. 2,3,6 Researchers are developing a single gel that contains both Nestorone and testosterone. 2 More recently, researchers developed orally active drugs with androgenic and progestogenic properties that raise the prospect of a single-agent MHC.…”

Section: Combination Male Hormonal Contraceptivesmentioning

confidence: 99%

“…2,3,6 Researchers are developing a single gel that contains both Nestorone and testosterone. 2 More recently, researchers developed orally active drugs with androgenic and progestogenic properties that raise the prospect of a single-agent MHC. 6 In a recent study, for example, 10 men received single, escalating, oral doses of dimethandrolone, which binds to androgen and progesterone receptors.…”

Section: Combination Male Hormonal Contraceptivesmentioning

confidence: 99%

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Rising to the challenge of male hormonal contraception

Greener¹

2017

Prescriber

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More than a quar ter of couples worldwide depend on male contraception.1 Yet, vasectomy aside, male contraceptives are not very reliable. The unintended pregnancy rate with condoms, for example, is 15% to 20% a year.2 This unreliability probably helps explain why more than half of men might try a male hormonal contraceptive (MHC).3 Indeed, new male contraceptives seem to be popular across all races, religions and ethnic backgrounds.

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The anti‐spermatogenic activity of nanoliposomes loaded with Heracleum persicum phenolic compounds in Balb/C mice

Alami,

Payrovnaziri,

Seghatoleslami

et al. 2023

Biotech and App Biochem

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There are various types of bioactivities that have been reported for Heracleum persicum species, such as antioxidant, anti‐inflammatory, and cytotoxicity properties. In the current study, the bio‐accessibility of H. persicum bioactive compounds was improved by purifying its phenolic‐enriched fractions (PEF) and encapsulating them into nanoliposomes to analyze its cytotoxic impacts on mice testicular tissue and their fertility status. Nano liposomal H. persicum PEF (NL‐HPEF) was prepared by ultrasound‐based encapsulation of HPEF and L‐agranular lecithin mixture. The size, morphology, and stability of NL‐HPEF were characterized by dynamic light scattering, field emission scanning electron microscopy, and zeta potential analysis. The 18 white male Balb/c mice (20–25 g) at 3 treatment groups were provided to study the NL‐HPPF cytotoxicity by measuring the mice liver enzyme including aspartate aminotransferase (AST), ALP and alanine aminotransferase (ALT), testis lipid peroxidation, and testicular tissue destruction levels. Moreover, the mice's fertility was evaluated by studying the Adam3, Prm1, Spata19, and Tnp2 gene expression in the testicular tissues. The obtained results manifested that the synthesized NL‐HPEF was stable (193.7 nm) and exhibited a notable cytotoxic impact on the mice's liver (ALT and AST enhancement levels) and testicular tissues. Moreover, their increasing treatment doses impaired the male mice's fertility by decreasing the sperm count, viability, and motility. In addition, fertility suppression was verified by decreasing serum testosterone and downregulating the Adam3, Prm1, Spata19, and Tnp2 gene expression in their testicular tissues. The male mice's fertility was significantly (p < 0.05) suppressed by increasing treatment doses of NL‐HPEF. Hence, the NL‐HPEF could be considered a promising alternative to replace the male chemical contraceptives drugs.

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Male contraception

Cited by 59 publications

References 84 publications

Determinants Factors of Vasectomy Method Selection

Determinants Factors of Vasectomy Method Selection

Rising to the challenge of male hormonal contraception

The anti‐spermatogenic activity of nanoliposomes loaded with Heracleum persicum phenolic compounds in Balb/C mice

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