Male choriocarcinoma with choroidal metastases.

Williamson, KA; Barry, D. R.; Sutton, G A; Jones, E. L.; Crews, S. J.

doi:10.1136/bjo.78.2.155

Cited by 7 publications

(4 citation statements)

References 2 publications

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“…Table 1 presents all cases of reported spinal metastases found in a comprehensive literature search. [ 1 2 3 4 6 9 10 11 13 14 16 21 22 ] The first three reported cases of spinal choriocarcinoma in other young males all represent cases of advanced multi-system disease burden as in the case reported here. In fact, in two of the three prior cases, the spinal involvement was only found upon autopsy.…”

Section: Discussionmentioning

confidence: 63%

“…In fact, in two of the three prior cases, the spinal involvement was only found upon autopsy. [ 1 22 ] In the living male patient with spine, brain, kidney, lung, liver, and eye involvement, chemotherapeutic and radiation treatments have provided an excellent outcome for at least 4 years. [ 6 ] With an incidence of 0.5% of all testicular tumors, pure choriocarcinoma is very rare in men and typically originates from totipotent gonadal germ cells but often presents with advanced metastases.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

et al. 2014

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Background:There are few cases of choriocarcinoma metastases to the spine that have been reported. Most occurrences are in women with the gestational form of the tumor, and these now exhibit a very high remission rate with chemotherapeutic treatment, typically circumventing the need for spinal surgery.Case Description:In an effort to better understand treatment options for those rare instances when choriocarcinoma does find its way into the spine, we have synthesized a comprehensive literature review on the clinical cases of choriocarcinoma spinal metastases. We also describe our unique experience and decision-making involving the first reported case of surgical treatment of non-gestational choriocarcinoma spinal metastases in a male patient.Conclusion:Spinal surgery has a limited role in metastatic choriocarcinoma, but there is the potential for improving neurologic decline even in the rare and aggressive male variant of this disease.

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Section: Discussionmentioning

confidence: 63%

Section: Discussionmentioning

confidence: 99%

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

et al. 2014

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“…7 One case of choroidal metastases of GCT was complicated by CS and was described in a patient with a history of cryptorchidism and previous orchiectomy. 8 Another case describes a patient with intravitreal metastases 6 months after orchiectomy for testicular cancer. 9 A different case discussed a patient who was diagnosed with metastatic testicular cancer and presented with a large testicular mass and serous retinal detachment.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Mixed Germ-Cell Neoplasm Presenting As Retinal Detachment

Phelps

Kapadia

Chennuri

et al. 2012

JCO

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IntroductionTesticular cancer occurs in less than 1% of men; however, it is the most common malignancy among men ages 15 to 34 years old. 1 Risk factors for testicular cancer include a history of cryptorchidism, genetic disorders (ie, true hermaphroditism or gonadal dysgenesis), HIV infection, and testicular atrophy. Mediastinal origin of germ-cell tumor (GCT), presence of pulmonary and visceral metastases, and tumor markers are important prognostic factors. 2 The overall 5-year survival rate for nonseminomatous GCT has increased from 63% in 1963 to 95% in 2006 because of improved chemotherapy. 3,4 GCT often presents as a testicular mass, pain, swelling, or a feeling of heaviness in the testes or scrotum. Our patient demonstrates an unusual presentation of a mixed germ-cell neoplasm (MGCN) complicated by choriocarcinoma syndrome (CS), a diagnosis characterized by hemorrhagic metastases, and extremely elevated human chorionic gonadotropin (HCG). 5 Patients with CS are at high risk of pulmonary catastrophe during chemotherapy. Case ReportAn otherwise healthy 20-year-old man experienced sudden loss of vision in his left eye and sought ophthalmologic attention. In the two weeks prior, he had noticed gradually decreased vision in his left eye associated with irritation and pain with blinking. Ophthalmology examination revealed an intraocular mass-associated serous retinal detachment. Computed tomography (CT) scans of the brain and orbit demonstrated two large hemorrhagic masses within the posterior parietal and occipital lobes. The patient was admitted to the hospital to

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“…Because the lung, brain, and vulvo-vaginal region are the most common sites for metastases, vaginal bleeding, chest pain, and neurological signs such as seizures or stroke are the most common presentations of the disease [5]. Metastasis in the spine is extremely rare, and only a few cases have been reported in the literature (Table 1) [10][11][12][13][14][15][16][17][18][19][20][21].…”

Section: Methodsmentioning

confidence: 99%

Choriocarcinoma Presenting with Spinal Metastasis: Case Report and Review of the Literature

Ebrahimzadeh¹,

Hallajnejad²

2016

J Spine

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Gestational trophoblastic disease (GTD) is a spectrum of cellular proliferations originating from placental villous trophoblasts. Spinal metastasis of choriocarcinoma is rare, especially after a normal pregnancy. In this paper, we present a rare case of metastatic choriocarcinoma to the lumbar spine as the first manifestation of disease. The patient underwent surgery, and a dark red hemorrhagic, epidural mass was totally removed. Histopathologic studies on the mass and specimen from the episiotomy site led to a diagnosis of metastatic choriocarcinoma. Surgical resection has a limited role in metastatic choriocarcinoma, but it should be considered if rapid-onset neurological deficit appears due to spinal cord compression.

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Male choriocarcinoma with choroidal metastases.

Cited by 7 publications

References 2 publications

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature

Metastatic Mixed Germ-Cell Neoplasm Presenting As Retinal Detachment

Choriocarcinoma Presenting with Spinal Metastasis: Case Report and Review of the Literature

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